Enjoy learning a key technology. Undergraduates and beginning graduates in both first and second simulation courses have responded positively to the approach taken in this text, which illustrates simulation principles using the popular Simio product. This economy version substitutes grayscale interior graphics to keep costs low for students. This textbook explains how to use simulation to make better business decisions in application domains from healthcare to mining, heavy manufacturing to supply chains, and everything in between. It is written to help both technical and non-technical users better understand the concepts and usefulness of simulation. It can be used in a classroom environment or in support of independent study. Modern software makes simulation more useful and accessible than ever and this book illustrates simulation concepts with Simio, a leader in simulation software. Author This book can serve as the primary text in first and second courses in simulation at both the undergraduate and beginning-graduate levels. It is written in an accessible tutorial-style writing approach centered on specific examples rather than general concepts, and covers a variety of applications including an international flavor. Our experience has shown that these characteristics make the text easier to read and absorb, as well as appealing to students from many different cultural and applications backgrounds. A first simulation course would probably cover Chapter 1 through 8 thoroughly, and likely Chapters 9 and 10, particularly for upper class or graduate level students. For a second simulation course, it might work to skip or quickly review Chapters 1-3 and 6, thoroughly cover all other chapters up to Chapter 10, and use Chapter 11 as reinforcing assignments. The text or components of it could also support a simulation module of a few weeks within a larger survey course in programs without a stand-alone simulation course (e.g., MBA). For a simulation module that's part of a larger survey course, we recommend concentrating on Chapters 1, 4, and 5, and then perhaps lightly touch on Chapters 7 and 8. The extensibility introduced in Chapter 11 could provide some interesting project work for a graduate student with some programming background, as it could be easily linked to other research topics. The all new Chapter 12 will support learning about Industry 4.0, digital twins, and how simulation and simulation-based scheduling can contribute to successful implementations. Supplemental course material is also available on-line. Fifth Edition The new fifth edition is written for Simio Version 10, the latest in simulation technology. We have incorporated many new features as well as reader suggestions. We have enhanced the Monte Carlo, input analysis, and output analysis content, and added new coverage of data-driven and data-generated modeling techniques. Finally, we added a new chapter named Simulation-based Scheduling in Industry 4.0 which illustrates how simulation is contributing to the creation and effective operation of digital twins and operational scheduling and control.