Patient safety is of paramount importance for any drug discovery program. This course looks at some of the lessons learned which have influenced how promising molecules are currently evaluated for safety risks. In vitro and in vivo toxicology and safety studies are discussed, why they are performed, and how the data they provide guide a safety risk assessment, including determining a therapeutic index or safety window for a drug. Finally, the course will look at how safety data guide human dose selection, and some of the studies performed during clinical development.
Read more
Patient safety is of paramount importance for any drug discovery program. This course looks at some of the lessons learned which have influenced how promising molecules are currently evaluated for safety risks. In vitro and in vivo toxicology and safety studies are discussed, why they are performed, and how the data they provide guide a safety risk assessment, including determining a therapeutic index or safety window for a drug. Finally, the course will look at how safety data guide human dose selection, and some of the studies performed during clinical development.
Patient safety is of paramount importance for any drug discovery program. This course looks at some of the lessons learned which have influenced how promising molecules are currently evaluated for safety risks. In vitro and in vivo toxicology and safety studies are discussed, why they are performed, and how the data they provide guide a safety risk assessment, including determining a therapeutic index or safety window for a drug. Finally, the course will look at how safety data guide human dose selection, and some of the studies performed during clinical development.
Target audience: This course is suitable for life scientists, clinicians, and individuals from fields that support drug discovery (e.g., patents, finance, licensing, etc.) interested in learning more about the pharmaceutical/biotechnology sector. Advanced undergraduate coursework or practical familiarity/working knowledge in biological sciences and organic chemistry is recommended.
Three deals to help you save
What's inside
Syllabus
Preclinical Safety, part 1
Welcome, by the end of the course students will be able to: Recognize the role of toxicology in drug development and its differentiation from pharmacology. List and describe representative preclinical toxicology studies conducted to identify and quantify risks a small molecule may pose to a patient. Explain how preclinical safety assessments contribute to early human dose selection.
Read more
Syllabus
Good to know
Save this course
Save
Activities
Review Basic Pharmacology
Show steps
Review the basics of pharmacology to strengthen your understanding of drug development.
Browse courses on
Pharmacology
Show steps
-
Read a textbook chapter on basic pharmacology
-
Review lecture notes from an introductory pharmacology course
Explore In Vitro Toxicology Techniques
Show steps
Follow online tutorials to gain practical insights into in vitro toxicology methods used in drug development.
Show steps
-
Find online tutorials on in vitro toxicology techniques
-
Watch the tutorials and take notes on key concepts
-
Practice applying the techniques through simulations or exercises
Organize and Review Course Content
Show steps
Compile and review lecture notes, assignments, and other course materials to reinforce your understanding of key concepts.
Show steps
-
Gather all relevant course materials
-
Organize the materials in a logical order
-
Review the materials regularly to reinforce your learning
Show all three activities
Review Basic Pharmacology
Show steps
Review the basics of pharmacology to strengthen your understanding of drug development.
Browse courses on
Pharmacology
Show steps
- Read a textbook chapter on basic pharmacology
- Review lecture notes from an introductory pharmacology course
Explore In Vitro Toxicology Techniques
Show steps
Follow online tutorials to gain practical insights into in vitro toxicology methods used in drug development.
Show steps
- Find online tutorials on in vitro toxicology techniques
- Watch the tutorials and take notes on key concepts
- Practice applying the techniques through simulations or exercises
Organize and Review Course Content
Show steps
Compile and review lecture notes, assignments, and other course materials to reinforce your understanding of key concepts.
Show steps
- Gather all relevant course materials
- Organize the materials in a logical order
- Review the materials regularly to reinforce your learning
Career center
Reading list
Share
Similar courses
OpenCourser helps millions of learners each year. People visit us to learn workspace skills, ace their exams, and nurture their curiosity.
Our extensive catalog contains over 50,000 courses and twice as many books. Browse by search, by topic, or even by career interests. We'll match you to the right resources quickly.
Find this site helpful? Tell a friend about us.
We're supported by our community of learners. When you purchase or subscribe to courses and programs or purchase books, we may earn a commission from our partners.
Your purchases help us maintain our catalog and keep our servers humming without ads.
Thank you for supporting OpenCourser.
