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Adam Le Gresley, PhD

By the end of this course, you will be able to:

Analyze atomic structure, bonding theories, and molecular interactions to understand drug-receptor mechanisms

Evaluate acid-base equilibria, buffer systems, and redox reactions in biological and pharmaceutical contexts

Explain organic chemistry principles including functional groups, stereochemistry, and reaction mechanisms relevant to biomolecules

Apply pharmacokinetic and pharmacodynamic concepts to understand drug action, enzyme interactions, and antibiotic mechanisms

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By the end of this course, you will be able to:

Analyze atomic structure, bonding theories, and molecular interactions to understand drug-receptor mechanisms

Evaluate acid-base equilibria, buffer systems, and redox reactions in biological and pharmaceutical contexts

Explain organic chemistry principles including functional groups, stereochemistry, and reaction mechanisms relevant to biomolecules

Apply pharmacokinetic and pharmacodynamic concepts to understand drug action, enzyme interactions, and antibiotic mechanisms

Skills: Chemical Analysis, Laboratory Interpretation, Problem Solving, Critical Thinking

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What's inside

Syllabus

Chemistry: Introduction
Chemistry is the scientific study of the properties of matter. It is a natural science that involves the elements that make up matter—their compositions, structures, properties, and behaviors, as well as the changes they undergo when reacting with other substances. At its most basic level, chemistry helps to explain how molecules and atoms may interact via chemical bonds and form new chemical compounds. In the body, this can be applied to our fundamental building blocks—for example, explaining why DNA behaves the way it does, how proteins fold, and why cell membranes have hydrophilic and hydrophobic compartments. Clinically, we encounter chemistry most often as it applies to pharmaceuticals and pharmacology. It governs the behavior of these molecules in our bodies, as with regard to bioavailability to binding sites and other characteristics.
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Learners who complete Chemistry will develop knowledge and skills that may be useful to these careers:

Reading list

We've selected 43 books that we think will supplement your learning. Use these to develop background knowledge, enrich your coursework, and gain a deeper understanding of the topics covered in Chemistry.
Considered the 'bible of pharmacology,' this comprehensive text provides an in-depth understanding of the principles of drug action and their clinical applications. It is an essential reference for graduate students and working professionals, offering detailed information on a wide range of therapeutic agents and their mechanisms. is invaluable for solidifying a deep understanding and is commonly used in academic and professional settings.
This widely respected textbook offers a clear and accessible introduction to pharmacology, covering fundamental principles and the actions of major drug classes. It is highly recommended for undergraduate students and can serve as a strong foundation for those new to the field. The book's clear illustrations and focus on mechanisms make complex topics easier to grasp. It is commonly used as a core textbook in universities.
Widely used textbook covering the principles of biopharmaceutics and pharmacokinetics. It is particularly useful for undergraduate and graduate students in pharmacy and pharmaceutical sciences. The book includes problem sets and examples to solidify understanding and is considered a strong reference tool in the field.
This newer edition building upon the classic Rowland and Tozer text, incorporating pharmacodynamics more explicitly. It's an authoritative text for graduate students and professionals, reflecting the increasing understanding of the link between PK and PD.
This advanced-level text focuses on the application of pharmacokinetic methods and pharmacodynamic principles for optimal drug therapy and therapeutic drug monitoring. It includes case studies and rigorous yet practical resource for professionals and advanced students.
Is valuable for both beginners and experienced scientists in pharmacokinetics and pharmacodynamics. It focuses on data analysis and modeling, providing numerous examples and tutorials. It is particularly relevant for those interested in quantitative pharmacology and pharmacometrics.
Integrates pharmacology with physiology and pathophysiology, helping readers understand how drugs interact with the body in the context of disease. It's suitable for undergraduate and graduate students, providing a strong foundation for understanding the rationale behind drug therapy. The focus on pathophysiological basis adds depth to the understanding of drug actions.
Examines the pharmacology of anticancer drugs, covering their discovery, development, and how they interact with cancer cells. It is essential for researchers and clinicians in oncology and pharmacology, reflecting contemporary topics in targeted therapies and personalized cancer treatment. This book is highly relevant for understanding modern approaches in a critical disease area.
This comprehensive textbook provides a broad overview of organic chemistry, covering the fundamental principles, reactions, and applications of organic molecules. It is written in a clear and concise style, with numerous examples and exercises to help students understand the material.
Focuses on Physiologically Based Pharmacokinetic (PBPK) modeling, a contemporary and advanced topic in pharmacokinetics. It is suitable for graduate students and professionals interested in this specific modeling approach used in the pharmaceutical industry.
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Known for its clear, visual format, this book is excellent for reviewing and understanding key pharmacological concepts. The illustrations and concise text make it particularly useful for students who benefit from visual learning and for quick review. It is often used as a supplementary text or for board exam preparation, providing a solid overview of essential pharmacology.
This textbook provides a fundamental understanding of pharmacokinetic principles and their application in drug therapy. It's well-suited for undergraduate students and those new to the subject. The book uses visual aids and includes problem sets with solutions to help solidify learning. The latest edition includes new chapters on pharmacodynamic dosing and Bayesian pharmacokinetics.
Introduces the rapidly evolving field of pharmacogenomics, explaining how genetic variations can influence drug response. It is relevant for advanced students and professionals interested in personalized medicine and the future of drug therapy. This book dives into a contemporary topic, adding breadth to a traditional pharmacology background.
Known for its case-study format, this book clarifies complex pharmacokinetic concepts and their application in patient care. It's suitable for students and clinicians, divided into basic principles and clinical applications. The latest edition includes new chapters on pharmacokinetics in specific patient populations.
This updated textbook and workbook combination widely used resource in clinical pharmacokinetics. It helps students and practitioners stay current with the latest advances in the field and provides practice problems to solidify understanding and application of concepts.
Explores the role of pharmacology in the drug discovery and development process. It is valuable for students and professionals interested in the pharmaceutical industry, covering topics from target identification to clinical trials. This book provides context for how pharmacological principles are applied in bringing new drugs to market.
Focuses specifically on therapeutic drug monitoring (TDM), an essential clinical application of pharmacokinetics. It provides practical guidance for healthcare professionals involved in monitoring drug levels to optimize patient therapy.
Tailored specifically for nursing students, this book focuses on the pharmacological knowledge and skills necessary for safe and effective patient care. It integrates pharmacology with pathophysiology and the nursing process, making it highly relevant for this audience.
Simplifies the complex subject of clinical pharmacokinetics for pharmacy students and practitioners. It focuses on fundamental concepts and clinical applications, using a step-by-step approach. It useful resource for solidifying understanding and is commonly used in academic settings.
Introduces computational approaches to pharmacokinetics and pharmacodynamics using the R programming language. It is suitable for students and researchers who want to learn how to apply computational tools for PK/PD analysis and modeling.
Delves into the molecular and cellular basis of drug action, exploring how drugs interact with biological targets at a fundamental level. It is ideal for advanced undergraduate students, graduate students, and researchers interested in the molecular aspects of pharmacology and drug discovery. This book provides depth in understanding the 'how' behind drug effects.
Offers a comprehensive description of essential topics in contemporary pharmacokinetics and pharmacodynamics. It includes interactive computer simulations to help students visualize and understand PK/PD models, making it a valuable learning tool.
A widely used textbook, particularly in some international medical programs, this book provides a comprehensive overview of pharmacology with a focus on essential concepts and drug information. It solid resource for medical and pharmacy students for gaining a broad understanding.
A textbook covering the fundamentals of analytical chemistry and quantitative analysis, with a focus on environmental and industrial applications. is suitable for undergraduate students and provides a good overview of the field.
Considered a classic in pharmacology, this comprehensive text includes substantial sections on pharmacokinetics. While not solely focused on PK, it provides essential foundational knowledge within the broader context of drug action. It's a valuable reference for students and professionals in various health science fields.
Introduces basic pharmacokinetic concepts for beginner learners, covering absorption, distribution, metabolism, and excretion. It emphasizes the application of concepts in clinical practice with the use of graphs and simulations. It's a good introductory text for undergraduate students.
A practical guide to using spectroscopic techniques, such as IR, UV-Vis, NMR, and mass spectrometry, for identifying organic compounds. is particularly useful for students and researchers working in organic chemistry and related fields.
This concise and accessible textbook great choice for students who want to gain a basic understanding of organic chemistry. It covers the essential concepts in a clear and straightforward manner, with plenty of practice problems to help students master the material.
A condensed version of the larger Goodman & Gilman's text, this manual still provides a solid overview of pharmacology, including key pharmacokinetic principles. It's a good option for those who need a less exhaustive but still authoritative reference.
This concise book provides a quick summary of essential pharmacokinetic concepts, making it ideal for those who need a brief introduction or review. It's suitable for students and professionals looking for a straightforward explanation of the basics.
This textbook is tailored for a range of health science professionals, offering a broad introduction to pharmacology with a focus on practical applications. It covers essential drug information and principles relevant to various healthcare disciplines.
Provides a concise overview of essential pharmacokinetic principles. It can serve as a good supplementary text or a quick reference for students and professionals who need to reinforce their understanding of the core concepts.
The 9th edition of Rang & Dale's Pharmacology solid, slightly older version of a highly-regarded textbook. It provides comprehensive coverage of pharmacological principles and drug classes, suitable for undergraduate study and as a foundational reference. While the 10th edition is preferred for the most current information, this edition is still valuable for core concepts.
While an older edition, the 12th edition of Goodman & Gilman's remains a classic and valuable reference for foundational pharmacological knowledge. Much of the core information is still relevant, making it a useful resource for historical context and fundamental principles, though it lacks the most recent drug information.
A textbook covering the principles and techniques of bioanalytical chemistry, with a focus on applications in the life sciences. is suitable for graduate students and researchers working in fields such as biochemistry and medicine.
As the title suggests, this book is designed for beginners, offering a simple introduction to basic pharmacokinetic concepts. It's a suitable starting point for high school students or those with no prior knowledge of the subject.
Offers a lighthearted and accessible approach to learning pharmacology, using humor and illustrations to simplify complex topics. It is particularly well-suited for high school students or those in introductory programs who may find traditional textbooks intimidating. While not as comprehensive as larger texts, it provides a good starting point for gaining a broad understanding.
This reference book provides concise information on a wide range of drugs used in clinical practice, organized in an A-Z format. It useful tool for healthcare professionals needing quick access to drug facts, indications, and adverse effects.

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