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Phil Burns, Michael Routledge, and Heiko Wurdak

Most FutureLearn courses run multiple times. Every run of a course has a set start date but you can join it and work through it after it starts. Find out more The course is suitable for anyone with a general interest in the science behind causes of human disease. No previous knowledge or experience is required. If you are working in nursing, healthcare or social care, or just wish to learn more, this course is designed to support you as a professional. By completing all aspects of the course you will have achieved 14 hours of CPD time. You can use the hashtag #FLgeneticsdisease to talk about this course on social media.

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Most FutureLearn courses run multiple times. Every run of a course has a set start date but you can join it and work through it after it starts. Find out more The course is suitable for anyone with a general interest in the science behind causes of human disease. No previous knowledge or experience is required. If you are working in nursing, healthcare or social care, or just wish to learn more, this course is designed to support you as a professional. By completing all aspects of the course you will have achieved 14 hours of CPD time. You can use the hashtag #FLgeneticsdisease to talk about this course on social media.

Topics Covered

  • The chemical structure of DNA, genes and chromosomes.
  • The importance of DNA in understanding the causes of genetic diseases.
  • DNA replication and cell reproduction.
  • The role of genes and proteins in controlling the activities of the cell and the cell cycle.
  • How genes and chromosomes can be permanently altered when mistakes happen during DNA replication.
  • The wide variety of different agents that can cause cancer.
  • The differences between normal cells and cancer cells.
  • Causes of genetic disease.
  • Different types of genetic diseases and how they may arise.

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Reviews summary

Exploring cancer and genetic disease causes

According to learners, this course provides a largely positive introduction to the causes of human disease, focusing on cancer and genetic factors. Students particularly appreciated the clear explanations of complex topics like DNA, genes, and cell processes, making it highly suitable for those with limited or no prior scientific background. Many found the lectures engaging and the content well-structured, providing a solid foundational overview. However, some reviewers noted that while it offers a good starting point, the course content can be too basic for those with existing knowledge in biology or healthcare, lacking the depth needed for advanced understanding or professional application beyond a general refresher.
Covers key causes of disease broadly.
"It covers the basics well. Instructor is knowledgeable."
"Provided a good overview of both genetic diseases and factors contributing to cancer."
"The topics covered were exactly as described and gave me a good foundation."
"I appreciated learning about both the genetic and environmental causes."
Instructors explain topics effectively.
"The lectures were engaging and kept my attention throughout the course."
"Found the way the material was presented in the videos really easy to follow."
"Instructors are knowledgeable and present the content clearly."
"I enjoyed the teaching style of the presenters."
Accessible and suitable for those new to the topic.
"Excellent introduction, clearly explained complex genetics and cancer concepts. Great for someone with limited biology background."
"Suitable for anyone with a general interest in the science behind causes of human disease. No previous knowledge or experience is required."
"This is a perfect course for absolute beginners in genetics and cell biology."
"I learned a lot starting from scratch. They assume no prior knowledge."
Complex topics are made easy to understand.
"The course content was well presented and explained in easy to understand terms, particularly in relation to DNA."
"Very clear explanations of complex topics like genetics and cell division. Excellent for beginners."
"Found the way they broke down DNA structure and gene function really helped solidify my understanding."
"I had very little science background, but the instructors explained everything so clearly."
May be too basic if you have prior knowledge.
"Solid course, covers the basics well... A bit simplistic if you already have a science degree, but a good refresher."
"Okay course. Content is introductory, good for absolute beginners. Found it lacked depth in some areas, especially genetic testing implications."
"Too basic, wasted my time. If you know anything about biology, skip this."
"I was hoping for more advanced information, but it only scratched the surface."

Career center

Learners who complete Causes of Human Disease: Exploring Cancer and Genetic Disease will develop knowledge and skills that may be useful to these careers:

Reading list

We've selected 50 books that we think will supplement your learning. Use these to develop background knowledge, enrich your coursework, and gain a deeper understanding of the topics covered in Causes of Human Disease: Exploring Cancer and Genetic Disease.
Classic textbook of molecular biology, covering all aspects of the field.
A foundational textbook in cancer biology, this book delves into the molecular and cellular mechanisms underlying cancer development and progression. It is essential for deepening understanding at the undergraduate and graduate levels and serves as a key reference for professionals. While comprehensive, its technical depth makes it more challenging for those without a strong science background.
Considered the definitive textbook in cell biology, this comprehensive volume covers the fundamental principles and latest research. It is widely used in advanced undergraduate and graduate programs and serves as an invaluable reference for researchers. The book provides a deep and broad understanding of cellular processes.
A comprehensive and authoritative clinical oncology textbook, often referred to as the 'bible' of oncology. covers all aspects of cancer care, from principles of treatment to site-specific management. It is an essential reference for medical students, residents, fellows, and practicing oncologists.
This textbook provides a comprehensive overview of genetic disorders from a molecular perspective. It covers the basic principles of genetics, the molecular basis of genetic disorders, and the latest advances in diagnosis and treatment.
This textbook provides a comprehensive overview of genetics and genomics with a strong focus on their relevance to medicine. It's an excellent resource for medical students and those in related fields, covering fundamental genetic principles, clinical applications, and the impact of genomic technologies on healthcare.
Co-authored by one of the pioneers of CRISPR technology, this book provides an insightful look into the world of gene editing. It discusses the science behind CRISPR and its potential implications for medicine and evolution, while also addressing the ethical considerations. This crucial read for understanding contemporary genetics and the future of genetic engineering.
A widely used textbook in medical schools and genetics programs, this book focuses on the principles of human genetics and their application in medicine. It covers Mendelian inheritance, chromosomal disorders, molecular genetics of human disease, and genetic counseling. This core resource for students pursuing careers in healthcare and medical research.
This textbook provides a detailed and up-to-date account of human molecular genetics. It covers the molecular basis of human genetic variation, disease, and gene therapy. It is an essential resource for students and researchers in human genetics, medical genetics, and molecular biology. is suitable for advanced undergraduate and graduate levels and serves as a key reference in the field.
Explores the findings and implications of The Cancer Genome Atlas (TCGA), a landmark project that molecularly characterized thousands of tumors. It delves into contemporary genomics topics in cancer research and is valuable for graduate students and researchers interested in large-scale genomic data analysis in cancer.
A highly influential popular science book that presents a gene-centered view of evolution. While not a genetics textbook in the traditional sense, it provides a compelling framework for understanding how genes can influence behavior and evolution. It's an excellent book for gaining a broader perspective on genetics within the context of evolutionary biology and is considered a must-read for anyone interested in the subject.
Provides an accessible introduction to the field of epigenetics, explaining how gene expression can be modified without alterations to the underlying DNA sequence. It discusses the mechanisms and implications of epigenetics in development, disease, and inheritance. This is an important book for understanding a rapidly evolving area of genetics.
This textbook provides a comprehensive and up-to-date overview of the field of genetics, including a thorough discussion of DNA. It is written by a leading expert in the field and is known for its clear and engaging writing style.
This textbook covers a broad range of central genetic concepts, including DNA structure and function, gene expression, mutations, genetic variation, and genetic technologies. It is suitable for advanced students and can provide a comprehensive understanding of genetics, including its relevance to genetic diseases.
Provides a comprehensive overview of genetics, including molecular biology.
Provides a comprehensive overview of molecular biology techniques.
This more concise and accessible version of 'Molecular Biology of the Cell', ideal for undergraduates or those new to the field. It provides a strong foundation in the core concepts of cell biology without overwhelming detail. is excellent for gaining a broad initial understanding.
Delves into the complex nature of heredity, moving beyond simple Mendelian inheritance to explore the various ways traits are passed down and the factors that influence them. It covers topics like epigenetics, the microbiome, and the history of heredity research. It's a thought-provoking read for gaining a deeper and more nuanced understanding of inheritance.
This textbook offers a comprehensive introduction to genetics, bridging classical genetics with modern genomics. It's well-regarded for its clear explanations and coverage of a wide range of topics, making it suitable for undergraduate students. It provides a strong foundation for understanding both the basic principles and the application of genomic technologies.
This widely-used textbook provides a broad introduction to genetics, covering both classical and molecular genetics principles. It's well-suited for undergraduate students gaining a fundamental understanding of the subject. The book's clear language and comprehensive coverage make it a solid resource for building a strong base in genetics. It is often used as a core textbook in introductory genetics courses.
Another popular textbook for introductory genetics, this book emphasizes fundamental concepts and their applications. It includes case studies and focuses on making genetics accessible to students. It's a comprehensive resource suitable for undergraduate students and is frequently adopted for genetics courses.
This textbook provides a balanced introduction to cell biology with a focus on molecular mechanisms. It is well-suited for undergraduate students and offers clear explanations of complex processes. The book is valuable for both initial learning and as a reference.
Written by a leading researcher in the field of ancient DNA, this book explores how the study of ancient genomes is revolutionizing our understanding of human history and evolution. It discusses major migrations, interbreeding with extinct human relatives, and the genetic basis of human diversity. is valuable for those interested in the intersection of genetics, anthropology, and archaeology.
A classic in the field of molecular biology, this book provides a comprehensive and detailed exploration of the molecular mechanisms underlying genetic processes. It's suitable for advanced undergraduate and graduate students seeking a deep understanding of DNA replication, transcription, translation, and gene regulation. While foundational, newer editions incorporate contemporary findings, making it a valuable reference.
Tells the story of the development of cancer immunotherapy, highlighting the scientific breakthroughs and the personal journeys of researchers and patients. It provides an engaging look at a contemporary and rapidly advancing field in cancer treatment, accessible to a broad audience while offering valuable context.
This popular science book explores the human genome by dedicating a chapter to each chromosome. It discusses the genes found on each chromosome and their relation to human traits, diseases, and evolution. It's an engaging read for gaining a broad understanding of the human genome and its significance.
Is dedicated to the complex topic of how cells communicate with each other and respond to their environment. Cell signaling is fundamental to almost all aspects of cell biology and major area of contemporary research. Suitable for upper-level undergraduates and graduate students.
Focuses on the cellular and molecular mechanisms of the immune system. is highly relevant for understanding the specialized cell types and interactions involved in immunity. It provides deep insight into a specific area of cell biology with significant contemporary research.
This compelling narrative tells the story of Henrietta Lacks, whose cancer cells (HeLa) were taken without her knowledge and became invaluable for medical research. It explores ethical issues in research, the history of cell biology, and the impact on the Lacks family. It provides important context on the origins of a fundamental tool in cancer research.
This textbook focuses on the experimental approaches used in modern genetics, integrating classical genetic analysis with genomic approaches. It's suitable for advanced undergraduate students and provides insights into how geneticists design experiments and interpret data. It complements conceptual textbooks by focusing on the practical aspects of genetic research.
A classic text that provides a deep dive into the molecular mechanisms of gene function and heredity. It is foundational for understanding how genetic information is stored, replicated, and expressed within cells. While earlier editions are classics, the latest provides updated context.
Explores the latest advances in genomics and their applications in personalized medicine. It provides an overview of genomic technologies and discusses their potential impact on the diagnosis, treatment, and prevention of genetic diseases.
This textbook is designed for undergraduate and graduate students in genetic counseling and other health professions. It covers the basic principles of genetics and their applications in the diagnosis and management of genetic disorders.
A comprehensive and detailed textbook covering molecular genetics and genomics. It's a valuable resource for advanced undergraduate and graduate students, delving deep into gene structure, function, and regulation. is often used as a reference and is known for its in-depth coverage of molecular mechanisms. Newer editions are available, but the core content remains highly relevant.
Presents cancer as a product of somatic evolution, offering a unique and insightful perspective on cancer development and progression. It is valuable for deepening understanding by considering cancer within an evolutionary framework and is suitable for advanced undergraduate students, graduate students, and researchers.
Offers a concise and accessible introduction to essential cell biology concepts. It is suitable for undergraduate students or those needing a quick overview of the field. The book emphasizes connections between basic science and medicine.
Explores the principles and applications of systems biology, which seeks to understand biological systems as integrated networks. It is highly relevant to contemporary cell biology research using large-scale data. Suitable for graduate students and researchers interested in quantitative approaches.
This classic provides a personal and engaging account of the discovery of the structure of DNA. While not a textbook, it offers a unique historical perspective on a pivotal moment in genetics. It's valuable for understanding the scientific process and the personalities involved, providing a human element to the history of the field. is more valuable as additional reading to complement technical knowledge.
A poignant memoir by a neurosurgeon diagnosed with terminal lung cancer, this book offers a deeply personal perspective on facing mortality and illness. While not a scientific text, it provides invaluable insight into the patient experience, which is crucial for anyone involved in cancer care or seeking a humanistic understanding of the disease.
Written by a physician and cancer survivor, this book explores lifestyle factors, including diet, exercise, and stress reduction, that can complement conventional cancer treatment and help prevent recurrence. It aligns with courses on nutrition and well-being and offers practical, evidence-informed strategies for patients and those interested in preventative measures.
This foundational and comprehensive laboratory manual for molecular biology techniques, including many essential to genetics research. While not a textbook for theoretical concepts, it is an indispensable reference for anyone performing experiments in molecular genetics. It provides detailed protocols and background information on a wide range of techniques. crucial reference tool for researchers and advanced students.
Given the relevance of viruses to cell biology as highlighted in the course titles, this book provides a comprehensive understanding of viruses and their interactions with host cells. It covers viral structure, replication, and pathogenesis at a molecular level. Relevant for understanding cell-virus interactions.

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