ATTENTION: Aspiring, New, and Retail Pharmacy Technicians
Do you want to learn....
"How To Transition From A Retail Pharmacy To A Compounding Pharmacy Setting Without Experience Or Formal Training"
Say YES. I'm ready to Make more than what retail pharmacy technicians make.
Say YES. I still want to be in the pharmacy or medical field but, I DON'T WANT the responsibility of talking or interacting with angry patients, and
Say YES. I want to be in a fun, more relaxed pharmacy setting while "making something" for my patients.
Read more
ATTENTION: Aspiring, New, and Retail Pharmacy Technicians
Do you want to learn....
"How To Transition From A Retail Pharmacy To A Compounding Pharmacy Setting Without Experience Or Formal Training"
Say YES. I'm ready to Make more than what retail pharmacy technicians make.
Say YES. I still want to be in the pharmacy or medical field but, I DON'T WANT the responsibility of talking or interacting with angry patients, and
Say YES. I want to be in a fun, more relaxed pharmacy setting while "making something" for my patients.
ATTENTION: Aspiring, New, and Retail Pharmacy Technicians
Do you want to learn....
"How To Transition From A Retail Pharmacy To A Compounding Pharmacy Setting Without Experience Or Formal Training"
Say YES. I'm ready to Make more than what retail pharmacy technicians make.
Say YES. I still want to be in the pharmacy or medical field but, I DON'T WANT the responsibility of talking or interacting with angry patients, and
Say YES. I want to be in a fun, more relaxed pharmacy setting while "making something" for my patients.
If You Act Now, You get a Lifetime Access to "Non-sterile Compounding Techniques Certification", including:
* The General Chapters of USP that pertain to compounding -
So
To Your Success,Prof. Lorraine LohnerP.S. - Every minute you wait to get "Non-sterile Compounding Techniques Certification" is another minute other pharmacy technicians will get further ahead of you and have more fun being pharmacy technicians.Disclaimer: This is not the official This course is for review or study guide purposes only. For official USP 795 information, go to the USP website.
What's inside
Learning objectives
- Understand basic concept of pharmaceutical compounding
- Define usp 795, usp 797 and usp 800 general chapters
- Differentiate sterile from non-sterile compounding
- Understand usp 795 general chapter - nonsterile pharmaceutical products compounding
- Learn techniques for non-sterile pharmaceutical compounding
- Understand basic concept of pharmaceutical compounding
- Define usp 795, usp 797 and usp 800 general chapters
- Differentiate sterile from non-sterile compounding
- Understand usp 795 general chapter - nonsterile pharmaceutical products compounding
- Learn techniques for non-sterile pharmaceutical compounding
Syllabus
Introduction to Compounding
Compounding Defined Part 1
Compounding Defined Part 2
In this section, students will learn the different chapters in the USP (United States Pharmacopeia) that pertains to compounding pharmaceuticals.
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Syllabus
Weighing
It is generally agreed that pharmaceutical products should be prepared with a low percentage of error. The official compendia allow a tolerance of ± 5% for most formulas, although greater accuracy may be required for very potent drugs with greater toxicity potential. This same degree of accuracy is expected in all extemporaneously compounded products.
Most pharmaceutical products allow for a tolerance of only 5% error, where
If we know the sensitivity of the balance (i.e. the potential error) we can calculate the percentage of possible error when any amount of the substance is weighed.
e.g. The Class III prescription balance has a sensitivity of 6 mg. What % of error would result in weighing 50 mg of a drug on the balance?
Similarly, we can calculate the smallest quantity that can be weighed, on a balance of known sensitivity, to maintain a desired level of accuracy. This weight is referred to as the least weighable quantity (L.W.Q.).
e.g. What is the least weighable quantity that will result in an error of 5% or less on a Class III prescription balance?
You should keep this figure in mind for the remainder of your career. When a prescription formula calls for the incorporation of a component weighing less than 120 mg, special methods must be employed to obtain that weight of the component. If a liquid dosage form (solution, suspension or emulsion) is being prepared, the liquid aliquot method is employed. When the component must be incorporated as a solid into powders, tablets, capsules, or pastes, the trituration method is used.
Reference: https://pharmlabs.unc.edu/labs/measurements/weigh.htm
Trituration Method
A trituration is a dilution of a potent drug powder with an inert diluent powder, usually lactose, in a definite proportion by weight. We can then remove a weighable portion (aliquot) of the mixture containing the desired quantity of substance to maintain an acceptable range of accuracy.
Using ratio and proportion, we can determine the weight of drug and lactose required to make the trituration as well as the weight of the aliquot to be used to fill the prescription.
Keep in mind that any substance that must be weighed on the balance drug (A), lactose (B-A), and aliquot (D) must be at least 120 mg.
Lactose is the most commonly used diluent in solid dosage form pharmaceuticals such as powders, tablets and capsules. Some of the reasons included its extremely low incidence of side effects, ready availability, and low cost.
Example: Make 10 capsules, each containing 0.6 mg Atropine Sulfate and each weighing a total of 200 mg.
Make Trituration
1. Total weight atropine sulfate required (this is C in the proportion)
2. Select some multiple of 6 mg that can be weighed with the desired degree of accuracy. (this is A in the proportion) (e.g. select multiple= 20)
3. Select the size of the aliquot portion to be taken to contain the 6 mg of drug. (this is D in the proportion)
4. Since we now have A, C, and D in our formula, we can solve for B(trituration weight).
[Note: this should be the multiple (20) x the weight of the aliquot (120 mg)]
5. Determine the weight of diluent (lactose) required to prepare the trituration by subtracting the weight of atropine sulfate from the trituration weight.
6. Fill Rx:
Determine the weight of lactose which must be added to the aliquot portion of trituration to complete the prescription, so that each capsule weighs 200 mg.
After the necessary calculations are completed, the trituration is prepared using the following steps:
- weigh a suitable amount of drug (at least 120 mg), and reduce it to a fine powder in a mortar (i.e., triturate it);
- weigh a suitable amount of diluent;
- mix the drug and diluent by geometric dilution and;
- weigh an aliquot of the trituration containing the desired weight of drug.
Hence the compounding procedure for this product is as follows:
- Weigh 120 mg atropine sulfate and triturate to a fine powder
- Weigh 2280 mg lactose
- Mix atropine sulfate and lactose by geometric dilution
Remove 120 mg of the trituration (contains 6 mg atropine sulfate) (Hint: save left over trituration for refills)
- Weigh 1880 mg lactose and mix with 120 mg aliquot by geometric dilution
- Prepare capsules weighing 200 mg each
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Reviews summary
Non-sterile compounding & usp 795 basics
Highly relevant for retail professionals.
Provides a solid regulatory foundation.
Visual guides for compounding methods.
Excellent guidance on calculations.
Activities
Review Pharmaceutical Calculations
Show steps
Reinforce your understanding of pharmaceutical calculations to ensure accurate compounding.
Show steps
-
Review basic math principles related to pharmaceutical calculations.
-
Practice solving various dosage calculation problems.
-
Familiarize yourself with different measurement systems and conversions.
Study 'USP 795: Pharmaceutical Compounding - Nonsterile Preparations'
Show steps
Gain a thorough understanding of the USP 795 guidelines for non-sterile compounding.
View
Melania
on Amazon
Show steps
-
Obtain a copy of the USP 795 guidelines.
-
Read and understand each section of the guidelines.
-
Identify key requirements and best practices.
Read 'Pharmaceutical Compounding and Dispensing'
Show steps
Expand your knowledge of compounding principles and techniques.
View
Putting Knowledge to Work
on Amazon
Show steps
-
Obtain a copy of 'Pharmaceutical Compounding and Dispensing'.
-
Read the chapters related to non-sterile compounding.
-
Take notes on key concepts and techniques.
Four other activities
Expand to see all activities and additional details
Show all seven activities
Practice Trituration Calculations
Show steps
Improve your proficiency in trituration calculations for accurate compounding of potent drugs.
Show steps
-
Review the trituration method and related calculations.
-
Solve practice problems involving different drug concentrations and capsule weights.
-
Verify your answers using a compounding calculator or reference materials.
Create a Compounding Log Template
Show steps
Develop a standardized template for documenting compounding procedures and calculations.
Show steps
-
Research best practices for compounding documentation.
-
Design a template that includes all necessary information, such as ingredients, calculations, and procedures.
-
Test the template by using it to document a sample compounding procedure.
Compound a Practice Formulation
Show steps
Apply your knowledge by compounding a simple non-sterile formulation under supervision.
Show steps
-
Select a simple non-sterile formulation to compound.
-
Gather all necessary ingredients and equipment.
-
Follow the compounding procedure carefully and document each step.
-
Have your work reviewed by a qualified pharmacist or technician.
Prepare a Presentation on Compounding Errors
Show steps
Research and present on common compounding errors and how to prevent them.
Show steps
-
Research common compounding errors and their causes.
-
Prepare a presentation that covers these errors and strategies for prevention.
-
Present your findings to your peers or colleagues.
Review Pharmaceutical Calculations
Show steps
Reinforce your understanding of pharmaceutical calculations to ensure accurate compounding.
Show steps
- Review basic math principles related to pharmaceutical calculations.
- Practice solving various dosage calculation problems.
- Familiarize yourself with different measurement systems and conversions.
Study 'USP 795: Pharmaceutical Compounding - Nonsterile Preparations'
Show steps
Gain a thorough understanding of the USP 795 guidelines for non-sterile compounding.
View
Melania
on Amazon
Show steps
- Obtain a copy of the USP 795 guidelines.
- Read and understand each section of the guidelines.
- Identify key requirements and best practices.
Read 'Pharmaceutical Compounding and Dispensing'
Show steps
Expand your knowledge of compounding principles and techniques.
View
Putting Knowledge to Work
on Amazon
Show steps
- Obtain a copy of 'Pharmaceutical Compounding and Dispensing'.
- Read the chapters related to non-sterile compounding.
- Take notes on key concepts and techniques.
Practice Trituration Calculations
Show steps
Improve your proficiency in trituration calculations for accurate compounding of potent drugs.
Show steps
- Review the trituration method and related calculations.
- Solve practice problems involving different drug concentrations and capsule weights.
- Verify your answers using a compounding calculator or reference materials.
Create a Compounding Log Template
Show steps
Develop a standardized template for documenting compounding procedures and calculations.
Show steps
- Research best practices for compounding documentation.
- Design a template that includes all necessary information, such as ingredients, calculations, and procedures.
- Test the template by using it to document a sample compounding procedure.
Compound a Practice Formulation
Show steps
Apply your knowledge by compounding a simple non-sterile formulation under supervision.
Show steps
- Select a simple non-sterile formulation to compound.
- Gather all necessary ingredients and equipment.
- Follow the compounding procedure carefully and document each step.
- Have your work reviewed by a qualified pharmacist or technician.
Prepare a Presentation on Compounding Errors
Show steps
Research and present on common compounding errors and how to prevent them.
Show steps
- Research common compounding errors and their causes.
- Prepare a presentation that covers these errors and strategies for prevention.
- Present your findings to your peers or colleagues.
Career center
Compounding Pharmacy Technician
Pharmaceutical Formulation Assistant
Quality Control Technician
Pharmacy Technician
Laboratory Assistant
Pharmaceutical Production Operator
Research Assistant
Formulation Scientist
Clinical Research Coordinator
Pharmaceutical Sales Representative
Medical Assistant
Health Educator
Medical Coder
Healthcare Administrator
Medical Scribe
Reading list
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