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Christelle Borel, Caroline Samer, Petros Tsantoulis, Idris Guessous, and Antoine Geissbuhler

This course will provide you with the key knowledge and tools to understand the fundamentals and practical implications of precision medicine, its opportunities and challenges. It will address precision-medicine era diagnostics, treatment selection, genetic counseling, public health interventions, and biomedical research. It will also deal with data science and ethical issues.

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This course will provide you with the key knowledge and tools to understand the fundamentals and practical implications of precision medicine, its opportunities and challenges. It will address precision-medicine era diagnostics, treatment selection, genetic counseling, public health interventions, and biomedical research. It will also deal with data science and ethical issues.

From genomic analysis and genetic counseling to cancer biomarkers, from risk assessment of chronic diseases to the understanding of gene-environment interactions, from pharmacogenomics to multi-omics data integration, experts will walk you through the many aspects of precision medicine, from the bench to the bedside and to population health.

Designed for students with a bachelor-level training in life sciences, this course will also be useful for professionals who are increasingly expected to deal with precision medicine, including primary care physicians and other first-line healthcare professionals, cancer and non-communicable diseases specialists, public health policy and decision makers, as well as biomedical researchers and drug developers.

Experts from the multiple domains of genetics and genomics, oncology, pharmacology, data sciences, ethics, and biomedical research will provide you with a comprehensive, multi-faceted overview of precision medicine, richly illustrated with practical examples and clinical case studies, and peppered with formative evaluations.

Whether you are interested or intrigued by topics such as “genethics”, the analysis of exome sequencing, precision diabetes management, hereditary cancers, the ongoing revolution of genetic technologies, genome-exposome interactions, the pharmacogenetics of opioids, data deidentification, blockchain-base patient-consent documentation, or proteomics and biomarkers, this course will explain the concepts, offer insights and present concrete examples, thus providing you with an overall understanding of the rapidly evolving field of precision medicine.

- update -

The contents of this course have been updated and important corrections have been implemented thanks to learners' feedback. Many thanks to them!

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What's inside

Syllabus

Monogenic Diseases
Complex Diseases
Cancer
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Health and Prevention
Pharmacogenomics and Drug Development
Research

Good to know

Know what's good
, what to watch for
, and possible dealbreakers
Provides a comprehensive introduction to precision medicine, its applications in healthcare, and its ethical implications
Taught by experts in genetics, oncology, pharmacology, data sciences, ethics, and biomedical research
Designed for students with a bachelor-level training in life sciences, professionals in healthcare, and researchers
Covers various aspects of precision medicine, from genomic analysis to data science and ethics
Incorporates practical examples and clinical case studies to illustrate the concepts
Course materials have been updated and improved based on learner feedback

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Reviews summary

Well-received precision medicine course

Learners say the Precision Medicine course is well received, largely due to its high-quality content and engaging style. Students praise the instructors' expertise, the practical nature of the material, and the up-to-date information provided. Many note that the course has broadened their understanding of precision medicine and its potential to transform healthcare. The quizzes and exams are sometimes challenging, but many learners see this as a positive, as it reinforces the material. Overall, learners say this course is a valuable resource for anyone seeking to expand their knowledge of precision medicine.
Exams are challenging but fair
"The tests were very challenging😅"
"I don't think it was ideal for learning purposes."
Course focuses on the practical implications of precision medicine
"not classes enfocadas en hablar y hablar de conceptos teóricos, sino más bien desde una perspectiva más práctica en la aplicación clínica"
"It gave me an insight into practical implementation of precision medicine from different perspectives."
Instructors are knowledgeable and experienced
"The instructors'expertise and the interactive nature of the course made complex topics in precision medicine accessible and engaging."
"you deserve a 5 star. The course is so amazing and well explored by well composed instructors who used different methods to make the concept easy to grasp."
"The precision medicine course is a fantastic curriculum that gives a thorough overview of the most recent advances in precision medicine."
Lectures and case studies are well-structured and informative
"Learned so much!"
"informative course"
"Very well curated and informative"
"An eye opening future field of medicine!"

Activities

Be better prepared before your course. Deepen your understanding during and after it. Supplement your coursework and achieve mastery of the topics covered in Precision Medicine with these activities:
Read 'The Code Breaker' by Walter Isaacson
Gain insights into the history and advancements of genetic research, particularly in the field of precision medicine.
Show steps
  • Read the book and take notes on key concepts and discoveries.
  • Summarize the main arguments and evidence presented in the book.
  • Reflect on the implications of genetic research for personalized medicine and society.
Review Mendelian Inheritance
Review the basics of Mendelian inheritance to strengthen your understanding of genetic principles.
Browse courses on Genetics
Show steps
  • Study the principles of dominant and recessive alleles.
  • Practice solving genetics problems involving monohybrid crosses.
  • Review the concepts of Punnett squares and genotype and phenotype ratios.
Compile a Glossary of Precision Medicine Terms
Enhance your understanding of precision medicine terminology by compiling a comprehensive glossary.
Browse courses on Terminology
Show steps
  • Gather definitions of key terms from textbooks, articles, and online resources.
  • Organize the definitions alphabetically or by topic.
  • Review and update the glossary as you progress through the course.
Six other activities
Expand to see all activities and additional details
Show all nine activities
Explore Precision Medicine Resources
Familiarize yourself with online resources and tools for precision medicine research and applications.
Browse courses on Data Science
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  • Identify and access databases of genomic and clinical data.
  • Explore tools for data analysis and visualization.
  • Learn about ethical considerations in precision medicine research.
Discuss Ethical Implications of Precision Medicine
Engage in discussions with peers to explore the ethical challenges and considerations surrounding precision medicine.
Browse courses on Ethical Implications
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  • Read and discuss academic papers on the ethical implications of precision medicine.
  • Analyze case studies involving ethical dilemmas in genetic testing and treatment.
  • Develop and present your own perspectives on the ethical issues.
Analyze Variant Call Format (VCF) files
Gain hands-on experience in analyzing VCF files, a crucial skill for interpreting genomic data.
Browse courses on Bioinformatics
Show steps
  • Load and explore VCF files using bioinformatics software.
  • Identify and interpret different types of genetic variants.
  • Filter and annotate variants based on specific criteria.
Attend a Precision Medicine Conference
Connect with experts and stay updated on the latest advancements in precision medicine.
Browse courses on Networking
Show steps
  • Research and select a conference relevant to your interests.
  • Attend presentations and workshops to expand your knowledge.
  • Network with researchers, clinicians, and industry professionals.
Develop a Personalized Health Plan
Apply precision medicine principles to create a tailored health plan based on your unique genetic profile.
Browse courses on Health Management
Show steps
  • Gather and analyze your genetic and health data.
  • Identify lifestyle and environmental factors that influence your health.
  • Develop a personalized plan for diet, exercise, and preventive screenings.
Contribute to a Precision Medicine Open-Source Project
Gain hands-on experience and contribute to the advancement of precision medicine by contributing to an open-source project.
Browse courses on Bioinformatics
Show steps
  • Identify a relevant open-source project on platforms like GitHub or GitLab.
  • Review the project codebase and documentation.
  • Identify areas where you can contribute, such as bug fixes, feature enhancements, or documentation improvements.

Career center

Learners who complete Precision Medicine will develop knowledge and skills that may be useful to these careers:
Medical Geneticist
Medical Geneticists study the role of genes in health and disease. They provide genetic counseling to patients and families affected by genetic disorders, and work to develop new diagnostic and treatment strategies. This course provides a strong foundation in the principles of precision medicine, including topics such as monogenic and complex diseases, cancer, and pharmacogenomics. This knowledge would be invaluable to a Medical Geneticist, as it would allow them to better understand the genetic basis of disease and develop more personalized treatments.
Genetic Counselor
Genetic Counselors provide information and support to individuals and families at risk for or affected by genetic disorders. They help patients and families understand their genetic risks, and make informed decisions about their health care. This course would be very helpful for a Genetic Counselor, as it would provide them with a comprehensive overview of precision medicine, including topics such as monogenic and complex diseases, cancer, and pharmacogenomics. This knowledge would allow them to better understand the genetic basis of disease, and provide more effective counseling to their patients.
Bioinformatician
Bioinformaticians develop and apply computational tools and techniques to analyze biological data. They work in a variety of settings, including academia, industry, and government. This course would be very helpful for a Bioinformatician, as it would provide them with a strong foundation in the principles of precision medicine, including topics such as data science and ethical issues. This knowledge would allow them to develop more effective computational tools for analyzing biological data.
Pharmacist
Pharmacists dispense medications and provide information about their use to patients. They also work with physicians to develop and manage medication regimens. This course may be helpful for a Pharmacist, as it would provide them with a basic understanding of the principles of precision medicine, including topics such as pharmacogenomics and drug development. This knowledge would allow them to better understand the genetic basis of drug response, and provide more personalized medication recommendations to their patients.
Nurse Practitioner
Nurse Practitioners provide a variety of medical services, including diagnosing and treating illnesses, prescribing medications, and performing minor surgeries. They work under the supervision of a physician.
Physician Assistant
Physician Assistants provide a variety of medical services, including diagnosing and treating illnesses, prescribing medications, and performing minor surgeries. They work under the supervision of a physician.
Research Scientist
Research Scientists conduct research to advance scientific knowledge. They work in a variety of settings, including academia, industry, and government.
Lab Technician
Lab Technicians conduct laboratory tests and experiments. They work in a variety of settings, including hospitals, clinics, and research laboratories.
Healthcare Administrator
Healthcare Administrators plan, organize, and direct the delivery of healthcare services. They work in a variety of settings, including hospitals, clinics, and insurance companies.
Health Educator
Health Educators promote health and well-being. They work in a variety of settings, including schools, community centers, and workplaces.
Science Writer
Science Writers communicate scientific information to the public. They work for a variety of media outlets, including newspapers, magazines, and websites.
Patent Attorney
Patent Attorneys help clients obtain and protect patents. They work in a variety of settings, including law firms, corporations, and government agencies.
Investment Analyst
Investment Analysts research and analyze investments. They work for a variety of financial institutions, including banks, investment firms, and hedge funds.
Management Consultant
Management Consultants help organizations improve their performance. They work in a variety of industries, including healthcare, technology, and finance.
Teacher
Teachers plan, organize, and deliver instruction to students. They work in a variety of settings, including schools, colleges, and universities.

Reading list

We've selected nine books that we think will supplement your learning. Use these to develop background knowledge, enrich your coursework, and gain a deeper understanding of the topics covered in Precision Medicine.
A comprehensive textbook coveing the latest advances in genetics and genomics, providing a solid foundation for understanding the role of genetics in health and disease.
A comprehensive reference for researchers and statisticians working in the field of statistical genomics, covering a wide range of topics from population genetics to gene expression analysis.
A practical guide to the analysis of genes and proteins using bioinformatics tools and databases, providing hands-on experience for researchers and students.
A comprehensive textbook covering the molecular basis of cancer, providing a solid understanding of the genetic and molecular mechanisms underlying tumor development.
A valuable reference for researchers using statistical methods to analyze biological data, particularly relevant for those working with high-throughput genomic data.
A specialized resource for those interested in using the R programming language for genomic data analysis, providing practical examples and code.
An advanced resource for those interested in the field of proteomics and systems biology, covering the latest techniques and applications in this rapidly evolving area.

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