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Diederick E. Grobbee and Arno W. Hoes

Evidence forms the basis of modern medicine. Clinical research provides us with this evidence, guiding health professionals towards solutions to problems that they face in daily practice. Transferring existing problems in medical practice to a research setting is a challenging process that requires careful consideration. The practice of clinical epidemiology aims to address this through the application of established approaches for research in human populations, while at all times focussing on the problem at hand from a clinical perspective.

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Evidence forms the basis of modern medicine. Clinical research provides us with this evidence, guiding health professionals towards solutions to problems that they face in daily practice. Transferring existing problems in medical practice to a research setting is a challenging process that requires careful consideration. The practice of clinical epidemiology aims to address this through the application of established approaches for research in human populations, while at all times focussing on the problem at hand from a clinical perspective.

This course teaches the principles and practice of clinical epidemiology, drawing on real problems faced by medical professionals and elaborating on existing examples of clinical research. Medical researchers will lean how to translate real clinical problems into tangible research questions for investigation, gaining insight into some of the most important considerations when designing an epidemiological study along the way.

Core concepts will be introduced along four key themes: diagnosis, prognosis, treatment and etiology. Followers of this course will develop their understanding of the topics addressed through lectures from experts, peer interaction and review assignments.

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What's inside

Syllabus

About the course
Welcome! Here you will find general information about the course. The learning objectives, the structure, the format and the requirements of completion will be presented to you.
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Introduction to Epidemiology
The course will kick off with a brief introduction to some of the key concepts in epidemiological research. We will warm up with two introductory lectures, followed by a small by assignment, before diving further into the field of epidemiology from a clinical context.
Diagnostic Research
This week we begin at the start of the DEPTh model: Diagnosis and diagnostic research. Through a series of lectures, you will come across familiar challenges in the area of diagnosis and discover how these problems can be addressed by clinical research.
Prognostic Research
This week you will be introduced to the challenges of evidence-based prognostication: how can we best predict the course of a patient's health? You will learn this week how this kind of question can be addressed through epidemiological research, becoming familiar with how prognostic tools can be developed for use in guiding clinical decisions.
Intervention Research
In our final week of lectures, you will step into the world of intervention research, exploring the "Therapeutic" branch of the DEPTh model. We will focus on the study of intended and unintended effects, exploring a new kind of study design: the randomized controlled trial.
The Online Debate
The task this week is in the form of an online debate in which you will study an existing piece of clinical research and contribute to a discussion of this research, forming both an objective assessment and using that to develop your own opinions.
Exam and Conclusion
This is final assessment in the course: a quiz of 30 multiple choice questions that aim to test how well you can apply the knowledge you have gained throughout the course. Good luck!

Good to know

Know what's good
, what to watch for
, and possible dealbreakers
Provides an introduction to clinical epidemiology along with foundational concepts for future progression
Provides clinical problems as frameworks for study, which may help learners remember
Instructors are established researchers in the field
Taught through lectures and expert methods that enable students to step into the role of a clinical researcher
Peer interaction and review assignments increase engagement and understanding of concepts
Learners should first learn general epidemiology for a stronger foundation as this course begins with direct application in a clinical context

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Reviews summary

Highly rated epidemiology fundamentals

Learners say this is an engaging course that provides a solid foundation in the essentials of clinical epidemiology. Detailed lectures and informative discussions are taught by knowledgeable instructors alongside interactive exercises and real-world examples of research in action. Students appreciate the clear, visual explanations of complex concepts that make learning accessible.
Lectures are engaging and interactive.
"Nice, thought provoking, brain engaging, different, unusual ways to attract to learning and getting the feedback in innovative way"
"I liked this course, because the content was easily understandble and the lecturers were engaging."
"pre-readings, peer-assesment and various assignments as well, which made it more interactive."
Instructors are knowledgeable and passionate about the subject.
"The lecturers were exceptional. . . . I am passionately looking forward your next courses."
"crystal-clear explanations partnered with outstanding performance"
"I hope we could work on a research some day soon!"
Course includes real-world examples of clinical epidemiology.
"I enjoyed the examples, a very practical way to understand the concepts."
"Excellent content and very clear explanations, truly a gem in what clinical epidemiology is"
"Course contents are excellent and easily represent abstruse knowledge with given real-time examples."
Lectures are clear and easy to understand.
"the content was easily understandble"
"explanations partnered with outstanding performance"
"outstanding in imaging the concepts and aims of clinical research in a visual convincing way."
Course provides a solid understanding of clinical epidemiology.
"This course on the fundamentals of clinical epidemiology was for me a pleasure."
"provides the most sobering view on clinical epidemiology"
"adequately and equally emphasizing the strengths and weaknesses of this field"

Activities

Be better prepared before your course. Deepen your understanding during and after it. Supplement your coursework and achieve mastery of the topics covered in Clinical Epidemiology with these activities:
Attend a Workshop on Clinical Epidemiology
Attending a workshop allows you to engage with experts in the field and gain practical hands-on experience in clinical epidemiology.
Show steps
  • Research and identify relevant workshops
  • Register and attend the workshop
  • Participate actively in discussions and exercises
Introduction to Evidence-Based Medicine
Begin by reviewing a foundational textbook in the field of clinical epidemiology to provide a strong foundation for the methodologies you will learn in this course.
Show steps
  • Read chapters 1-3 of the textbook
  • Summarize the key concepts of each chapter
Using Statistical Software for Data Analysis
Gain proficiency in using statistical software to analyze and interpret epidemiological data.
Show steps
  • Familiarize yourself with the basics of statistical software
  • Learn how to load, clean, and manipulate data
  • Apply statistical methods to analyze epidemiological data
Five other activities
Expand to see all activities and additional details
Show all eight activities
Create a Study Protocol Outline
Developing the outline for a study protocol will enable you to understand the structure and essential components of designing an epidemiological study.
Show steps
  • Choose a topic for your study
  • Formulate a research question
  • Outline the study design
  • Identify the variables and data to be collected
Interpreting Research Articles
Interpreting research articles is a crucial skill for comprehending and applying the findings from clinical research to improve patient care.
Show steps
  • Identify the main research question and study design
  • Assess the validity and reliability of the findings
  • Interpret the results in the context of clinical practice
Peer Review of Study Protocols
Peer review is an essential part of the research process, allowing you to receive feedback and improve the quality of your study protocol.
Show steps
  • Share your study protocol outline with a peer
  • Provide constructive criticism and feedback to your peer
  • Incorporate feedback to refine your study protocol
Contribute to an Open-Source Epidemiology Project
Contributing to an open-source project allows you to apply your skills, collaborate with a community, and enhance your knowledge of epidemiology.
Show steps
  • Identify an open-source epidemiology project to contribute to
  • Review the project's documentation and codebase
  • Make a contribution to the project
Develop an Evidence-Based Clinical Guideline
Creating an evidence-based clinical guideline will provide an opportunity to apply your knowledge to develop practical recommendations for clinical practice.
Show steps
  • Identify a clinical topic and formulate a guideline scope
  • Conduct a systematic review of the literature
  • Develop clinical practice recommendations based on the evidence

Career center

Learners who complete Clinical Epidemiology will develop knowledge and skills that may be useful to these careers:
Biostatistician
A Biostatistician applies statistical methods to solve medical problems. By applying the knowledge and skills taught in this course, you'll be able to interpret existing biomedical research to evaluate its reliability and apply findings in your field. You'll need a doctorate or a master's degree to become a Biostatistician.
Physician Assistant
Physician Assistants practice medicine under the supervision of physicians. The principles of clinical epidemiology will help you interpret and apply the latest medical research to patient care and make clinical decisions.
Pharmacist
Pharmacists provide medication and patient counseling. This course will help you understand the principles of clinical epidemiology, which will allow you to evaluate the effectiveness and safety of medications, interpret clinical trial results, and provide accurate information to patients.
Nurse
Nurses provide a variety of medical care to patients. This course will provide you with the knowledge and skills in clinical epidemiology, so you can evaluate the quality of care and identify areas for improvement.
Epidemiologist
Epidemiologists investigate the causes of disease and other health problems in populations. This course may help you understand the principles of clinical epidemiology, which will help you conduct epidemiological studies, analyze data, and communicate study findings.
Public Health Analyst
Public Health Analysts plan, manage, and evaluate programs to improve the health of communities. This course will help you understand the principles of clinical epidemiology so that you can understand health data and trends and make recommendations for public health programs.
Health Policy Analyst
Health Policy Analysts analyze and evaluate health policies and programs. This course will help you understand the principles of clinical epidemiology, which will allow you to effectively read and evaluate research, translate evidence into policy, and make recommendations to improve public health.
Medical Writer
Medical Writers create and edit written materials about medical topics. This course may be useful for Medical Writers because it can teach you the principles of clinical epidemiology and how to interpret and write about medical research accurately.
Data Analyst
Data Analysts analyze data to identify trends and patterns. This course will help you understand the principles of clinical epidemiology and how to analyze and interpret health data.
Science Writer
Science Writers communicate complex scientific concepts to the public. This course may be useful to Science Writers who want to learn more about the principles of clinical epidemiology so that they can effectively write about medical research for various audiences.
Quality Improvement Analyst
Quality Improvement Analysts evaluate and improve the quality of healthcare services. This course may be helpful to Quality Improvement Analysts as it teaches the principles of clinical epidemiology, which can help you analyze data to identify areas for improvement in healthcare quality.
Clinical Research Coordinator
Clinical Research Coordinators assist with the design and implementation of clinical research studies. This course may be useful for Clinical Research Coordinators as it teaches the principles of clinical epidemiology, which can help you understand the research process and your role in it.
Clinical Research Associate
Clinical Research Associates manage clinical research studies. This course may be helpful for Clinical Research Associates as it teaches the principles of clinical epidemiology, which can help you understand the research process and regulatory requirements.
Medical Librarian
Medical Librarians help others find and access medical information. This course may be helpful for Medical Librarians as it teaches the principles of clinical epidemiology, which can help you understand the types of medical research available and how to access it.
Health Educator
Health Educators develop and implement educational programs to promote healthy behaviors. This course may be helpful for Health Educators as it teaches the principles of clinical epidemiology, which can help you understand the effectiveness of different health education programs.

Reading list

We've selected nine books that we think will supplement your learning. Use these to develop background knowledge, enrich your coursework, and gain a deeper understanding of the topics covered in Clinical Epidemiology.
Covers the key principles and methods of clinical epidemiology, providing a solid understanding of the subject for students and practitioners alike.
Provides a practical guide to the principles and methods of clinical epidemiology, focusing on their application in clinical settings.
This comprehensive textbook covers all aspects of epidemiology, providing a thorough grounding in the subject for students and researchers.
This textbook provides a clear and concise introduction to the basic principles of epidemiology, with a focus on their application in research and practice.
Provides a detailed overview of the statistical methods used in epidemiology, with a focus on their application in research and practice.
Provides a comprehensive overview of the practical aspects of epidemiological research, with a focus on their application in research and practice.
Provides a comprehensive overview of the methods used in epidemiological research, with a focus on their application in research and practice.

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