Toxicology 21: Scientific Applications from Coursera

What's inside

Syllabus

Module 1

This model will give you a broad introduction to the Toxicology 21st century (Tox21c) field and familiarize you with the main document, which summarize the main ideas and principles of Tox21c.

Module 2

This module will discuss how ToxCast and Tox21 technologies can be used in practice. The US EPA Endocrine Disruptor Screening Program will be discussed in detail and we will demonstrate how the ToxCast platform replaced in vivo tiered approaches in EDSP and, thus, acelerate the process of . In the second lesson of this module, the development of in silico models for toxicity testing will be discussed.

Module 3

This module will familiarize you with the Human Toxome Project run by Johns Hopkins University in collaboration with several university, industry, and research agencies. Omics technologies, their advantages and disadvantages, as well as concepts of Adverse Outcome Pathways (AOP) and Pathways of Toxicity (PoT) will be discussed.

Module 4

The first lesson in this module will explain the concept of read-across, why it is important for regulatory risk assessment, and how it can be implemented by industry in response to REACH legislation. The organotypic cultures lesson will teach you about existing in vitro cell-based models starting from simple monolayer cultures of cell lines and ending with complex combined organ-on-a-chip and human-on-a-chip approaches.

Module 5

This module will teach you the role of miRNA and epigenetics in toxicology and environmental health.

Module 6

In this module you will learn about important component of in vitro toxicology such as in vitro to in vivo extrapolation (IVIVE) and physiologically based biokinetic modeling. You will learn why it is important to consider biokinetics in vitro and see some example of biokinetics modeling in vitro. This lesson will also give you a biometry prospective of in vitro toxicology. You will learn which methods can be used to analyze big data.

Module 7

In this lesson you will learn about integrated testing strategies and how they differ from individual tests or test batteries. Also a wrap-up lesson "beyond chemical" will summaries your knowledge from this course and give a out-look for further directions in the field of alternatives to animal testing.

Good to know

Know what's good

, what to watch for

, and possible dealbreakers

Appropriate for professionals working in the field of toxicology and those seeking to apply the latest developments

Instructors Lena Smirnova and Thomas Hartung are recognized experts in toxicology

Teaches the latest developments in toxicology

Provides examples from real-world programs, such as the EPA Endocrine Disruptor Screening Program and the Johns Hopkins University Human Toxome Project

Covers important topics such as read-across, organotypic cultures, and in vitro to in vivo extrapolation

Teaches skills that are highly relevant to industry and academia

Reviews summary

Highly rated toxicology course

Learners say this highly rated course is well taught by knowledgeable instructors. By taking this course, students gain a clear understanding of the current trends in toxicology testing and its scientific applications. Students report that this course is worth the effort and time required to complete it.

The course is highly praised by learners.

"Very nice and the teachers explanation are clear."

"Very nicely designed course."

"Thanks for the opportunity to be part of this course."

"THIS IS ONE OF THE BEST COURSES EVER!!"

Instructors are experts in the field.

"Very informative one"

"Very nicely designed course. The instructors offer an excellent and easy to understand overview of a range of promising Tox21 tools and approaches using good examples and illustrations."

"one of the best course helps students & researcher about what are challenges faced in toxicology in 21 century and finds the routes to develop new routes and methods for toxicology tests"

"The availability of instructors from a vast variety of areas is the most important asset of this course."

Course provides up-to-date information on toxicology testing.

"Helpful Course in Understanding Current trend in toxicological testings"

"This was a very well run course with helpful activities. I have used the material in my profession."

"Thanks for the opportunity to be part of this course. With this course, I have been able to understand the current trend in the field of Toxicology where animal testing has giving a way for the new advance technology such as cell culture, omics, highthroughput test."

"The course conceptually describes the need for a change in the field of toxicity testing replacing the decades-old cruel method of animal testing."

Activities

Be better prepared before your course. Deepen your understanding during and after it. Supplement your coursework and achieve mastery of the topics covered in Toxicology 21: Scientific Applications with these activities:

Refine your critical thinking skills

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Practice critical thinking to better comprehend the complex concepts discussed in this course.

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Identify a real-world problem
Analyze the problem and gather relevant information
Generate potential solutions
Evaluate and select the best solution

Review the principles of toxicology

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Brush up on the fundamental principles of toxicology to enhance your understanding of the advanced concepts covered in this course.

Browse courses on Toxicology

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Read through textbooks or online resources
Attend introductory lectures or workshops
Review notes from previous toxicology courses

Explore ToxCast's online tutorials

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Enhance your understanding of ToxCast's capabilities by completing their online tutorials, providing hands-on experience with this valuable tool.

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Access the ToxCast website
Select and complete the available tutorials
Follow the instructions and explore the interactive features

Five other activities

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Read Casarett & Doull's Toxicology: The Basic Science of Poisons, 9th Edition

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Delve deeper into the field of toxicology by reading this comprehensive textbook, gaining insights from experts in the field.

View Casarett & Doull's Essentials of Toxicology,... on Amazon

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Purchase or borrow the book
Read through the relevant chapters
Take notes and highlight important concepts

Join a study group or online discussion forum

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Engage with peers to discuss course concepts, share insights, and enhance your understanding through collaborative learning.

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Identify or create a study group
Set regular meeting times
Prepare discussion topics and facilitate discussions

Develop a graphical representation of a toxicological pathway

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Reinforce your understanding of toxicological pathways by creating a visual representation, which can aid in memorization and recall.

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Choose a specific toxicological pathway
Research and gather information about the pathway
Design and create a graphical representation

Practice using online toxicology databases

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Enhance your research skills by practicing with online toxicology databases, becoming proficient in accessing and utilizing valuable information.

Browse courses on Database Searching

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Identify relevant toxicology databases
Learn search strategies and query techniques
Conduct practice searches and retrieve information

Volunteer at a local environmental organization

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Gain practical experience in the field of toxicology by volunteering at an environmental organization, applying your knowledge and making a real-world impact.

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Research and identify local environmental organizations
Contact organizations and inquire about volunteer opportunities
Attend volunteer training and orientation

Career center

Learners who complete Toxicology 21: Scientific Applications will develop knowledge and skills that may be useful to these careers:

Toxicologist

Toxicologists are scientists who work with a goal of protecting human health and the environment from harmful chemicals and other potentially dangerous substances. They study the effects of these substances on living organisms and work to develop ways to prevent or mitigate their harmful effects.

See salaries and explore the career path for Toxicologist

Regulatory Affairs Scientist

Toxicology plays an important role in the field of regulatory affairs by informing decisions about the safety and regulation of chemicals, products, and technologies. Regulatory affairs professionals use their toxicology knowledge to evaluate product safety, ensure compliance with regulations, and communicate safety information to stakeholders.

See salaries and explore the career path for Regulatory Affairs Scientist

Environmental Health Scientist

Toxicology is a key area of study for environmental health scientists who work to understand and mitigate the effects of environmental toxicants on human health and the environment. This course can provide environmental health scientists with a deeper understanding of the latest approaches and technologies used in toxicology.

See salaries and explore the career path for Environmental Health Scientist

Toxicological Pathologist

Toxicological pathologists study the effects of toxic substances on the body's tissues and organs. They work to determine the cause of death in cases of poisoning and to assess the safety of chemicals and other substances. This course can help toxicological pathologists stay up-to-date on the latest developments in toxicology and improve their understanding of the mechanisms of toxicity.

See salaries and explore the career path for Toxicological Pathologist

Research Scientist

Toxicology is a valuable area of expertise for research scientists working in the fields of environmental health, pharmacology, and drug development. This course can provide research scientists with the knowledge and skills needed to conduct toxicology studies, evaluate data, and interpret results.

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Biostatistician

Toxicology studies often involve large datasets, and biostatisticians are responsible for analyzing and interpreting this data. This course can provide biostatisticians with the skills needed to apply statistical methods to toxicology data and draw meaningful conclusions.

See salaries and explore the career path for Biostatistician

Epidemiologist

Toxicology is an important area of study for epidemiologists who work to investigate the causes and distribution of disease in populations. This course can provide epidemiologists with a deeper understanding of the role of toxic substances in disease development and help them to design and conduct studies to assess the health effects of exposure to toxic substances.

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Industrial Hygienist

This course is relevant to industrial hygienists who work to identify, evaluate, and control workplace hazards that can cause illness or injury to workers. Toxicology knowledge is essential for industrial hygienists to understand the potential health effects of hazardous substances and to develop effective strategies to protect workers from exposure.

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Safety Manager

Safety managers are responsible for developing and implementing safety programs to protect employees and the public from workplace hazards. Toxicology knowledge is important for safety managers to understand the potential risks associated with hazardous substances and to develop effective safety measures to minimize exposure.

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Risk Assessor

Toxicology is a key area of expertise for risk assessors who work to evaluate the potential risks of chemical substances, products, and processes to human health and the environment. This course can provide risk assessors with the knowledge and skills needed to conduct risk assessments and develop risk management strategies.

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Chemical Engineer

Toxicology knowledge is important for chemical engineers who work to design and operate chemical plants and processes. This course can provide chemical engineers with a deeper understanding of the potential hazards associated with chemicals and help them to design and operate plants and processes in a way that minimizes the risk of accidents and exposure to hazardous substances.

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Environmental Engineer

Toxicology knowledge is important for environmental engineers who work to protect the environment from pollution. This course can provide environmental engineers with a deeper understanding of the sources, transport, and fate of toxic substances in the environment and help them to develop effective strategies to mitigate the risks associated with these substances.

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Occupational Therapist

Occupational therapists work with individuals who have been injured or disabled to help them regain their independence and function. Toxicology knowledge can be helpful for occupational therapists who work with clients who have been exposed to toxic substances or who have conditions that may be affected by exposure to toxic substances.

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Health Educator

Health educators work to promote health and prevent disease in communities. Toxicology knowledge can be helpful for health educators who work on issues related to environmental health and the prevention of exposure to toxic substances.

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Regulatory Compliance Manager

Regulatory compliance managers are responsible for ensuring that their organizations comply with relevant laws and regulations, including those related to environmental health and safety. Toxicology knowledge is important for regulatory compliance managers who work in industries that use or produce hazardous substances.

See salaries and explore the career path for Regulatory Compliance Manager