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Molecular Evolution (Bioinformatics IV)

Bioinformatics,

In the previous course in the Specialization, we learned how to compare genes, proteins, and genomes. One way we can use these methods is in order to construct a "Tree of Life" showing how a large collection of related organisms have evolved over time. In the first half of the course, we will discuss approaches for evolutionary tree construction that have been the subject of some of the most cited scientific papers of all time, and show how they can resolve quandaries from finding the origin of a deadly virus to locating the birthplace of modern humans. In the second half of the course, we will shift gears and examine the old claim that birds evolved from dinosaurs. How can we prove this? In particular, we will examine a result that claimed that peptides harvested from a T. rex fossil closely matched peptides found in chickens. In particular, we will use methods from computational proteomics to ask how we could assess whether this result is valid or due to some form of contamination. Finally, you will learn how to apply popular bioinformatics software tools to reconstruct an evolutionary tree of ebolaviruses and identify the source of the recent Ebola epidemic that caused global headlines.

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Rating 4.2 based on 11 ratings
Length 7 weeks
Starts Aug 24 (5 weeks ago)
Cost $79
From University of California San Diego via Coursera
Instructors Pavel Pevzner, Phillip E. C. Compeau, Phillip Compeau
Download Videos On all desktop and mobile devices
Language English
Subjects Programming Science
Tags Computer Science Life Sciences Algorithms Bioinformatics Health Informatics

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What people are saying

although certain aspects

Although certain aspects of it were positive and in line with the quality of previous modules, this course had its problems.

at some point

At some point several instructors lost necessary passion to keep us focused.

without interactive text

Without interactive text, it's very difficult to comprehend by watching short videos.

algorithms for phylogenetic

Covers the most important algorithms for phylogenetic trees.

also evident when

This misalignment is also evident when we look at the quizzes and the final challenge, which hardly tackled the material of those two dreadful weeks.

always make out

I would have enjoyed it more if I had had enough knowledge to do the Honors quiz!I downloaded all the videos so I could play them over without chewing up my data, but the quality is so poor you can't always make out the writing - i's and j's all look similar.

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Rating 4.2 based on 11 ratings
Length 7 weeks
Starts Aug 24 (5 weeks ago)
Cost $79
From University of California San Diego via Coursera
Instructors Pavel Pevzner, Phillip E. C. Compeau, Phillip Compeau
Download Videos On all desktop and mobile devices
Language English
Subjects Programming Science
Tags Computer Science Life Sciences Algorithms Bioinformatics Health Informatics

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