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Jan Nico Bouwes Bavinck, Aiko de Vries, Frans Claas, Andre Baranski, Ingeborg Bajema, Hans de Fijter, Ton Rabelink, Volkert Huurman, Sebastiaan Heidt, Marlies Reinders, Eelco de Koning , Leo Visser , and Cees van Kooten

Kidney transplantation is a major advance of modern medicine which provides high-quality of life for patients with end-stage renal disease. What used to be an experimental, risky, and very limited treatment option more than 50 years ago is now routinely performed in many countries worldwide. The number of renal transplants is expected to rise sharply in the next decade since the proportion of patients with end stage renal disease is increasing.

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Kidney transplantation is a major advance of modern medicine which provides high-quality of life for patients with end-stage renal disease. What used to be an experimental, risky, and very limited treatment option more than 50 years ago is now routinely performed in many countries worldwide. The number of renal transplants is expected to rise sharply in the next decade since the proportion of patients with end stage renal disease is increasing.

Are you interested in clinical kidney, pancreas and islet transplantation? If you are a (bio) medical student or a health care professional who works in the (pre) clinical transplant field this might be the course for you. This course is also for anyone interested in the research and knowledge on clinical transplantation. The course will be taught by a multidisciplinary team of transplant professionals and will give you the state of the art updates.

It is divided in 4 modules:

1) Before the transplant

2) The surgical procedures and the challenged patient, including the patient with diabetes

3) Early challenges

4) Late challenges after transplantation.

The offered modules will include lectures, interactive patient cases, 3D movies, interviews with well-known experts and with patients and a donor, a serious game to increase knowledge of the field and of course an active forum. Become an expert and join us!

The course has been endorsed by The European Society of Organ Transplantation (ESOT), The International Society of Nephrology (ISN) and The Transplantation Society (TTS).

This MOOC has been accredited for Continuing Medical Education (CME). Health care professionals who works in the (pre) clinical transplant field, other health care professionals and general practitioners can obtain CME credit at 'LUMC-Boerhaave CME' upon passing the course. For more information we like to refer to the "Additional introduction for obtaining CME credit" module in week 1 of the course

For another interesting course on organ donation and transplantation, see Organ Donation: From Death to Life from Cape Town University https://www.coursera.org/learn/organ-donation

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What's inside

Syllabus

Welcome to the course
Great that you are joining us! In this course you will learn about clinical kidney, pancreas and islet transplantation and its challenges. Before you start with studying we invite you first go through our introduction module and introduce yourself in the forum to meet your fellow learners. If you encounter any difficulties while studying, please let us know in the forum. For technical difficulties or questions regarding the course certificate, you can always contact the Coursera Learner Helpdesk. Good luck & we hope you enjoy studying in this course!
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Before the Transplant
Welcome to this first module of the course! We will answer important questions before transplantation. These include: why is transplantation the preferred option for patients with end stage renal disease? What are the immunological barriers for transplantation? And what are the selection criteria before transplantation? Unique 3D movies about the different immunological tests will help you to understand the concepts. There are also optional lectures, including a fascinating movie about the Eurotransplant allocation system and patient/donor interviews. At the end of the module we will link the contents you have learned to clinical patient cases, patient - donor interviews and a quiz. You can find each other on the discussion forum. With the e-tivities you can apply your knowledge. In the honors lessons more in depth immunological testing and pre transplant screening can be obtained. The lesson also includes peer reviews about important preclinical questions. Have fun and good luck with the first module!
The Procedure and the Patient
Now you know the factors of importance before transplantation, including the immunological barriers and important aspects for patient selection, we can focus on challenged patient groups and on surgical procedures. What does a kidney, pancreas and islet transplantation surgical procedure look like? What is important? And what are the key aspects in elderly patients, patients with diabetes and immunological challenged patients. We have unique visulisations, 360 virtual reality videos and a game about a patient case. Advanced readings will invite you to look at the different subjects in more depth. At the end of the module there are interviews about a patient with diabetes and the transplant recipient and donor to illustrate the impact of life. You can discuss patient cases on the forum together with your peers. In the honors lesson you can apply knowledge about more in depth immunological, surgical and metabolic challenges and living kidney donation. Let’s start and we hope you will enjoy this module.
Early Challenges in Transplantation
You are now familiar with the basic knowledge about challenges in transplant recipients and the surgical transplant procedures. Once the transplantation has been successful, it doesn’t mean everything is stable. What are actually the graft survival data? Which challenges do we face in the first months? How can we tackle these challenges? 3D movies about early surgical challenges and about the targets for immunosuppressives, including cell therapy, will help you to understand the concepts. In addition, we invite you to master the advanced knowledge and to give your opinion in the patient cases in the forum. There is also a serious game about a patient case. Can you solve the challenges? And can you think of a scenario for the game and help us with building? We will make a game of the best scenario, which will be incorporated in the course. In the honors lesson you can learn in more detail about immunological concepts, including the complement system. A patient case will help to show you the importance of this knowledge. Good luck with this module and happy learning!
Late Challenges in Transplantation
Now you’ve learned about the challenges in the early period after transplantation. But what about the late period? What is the long term patient and allograft survival? Have we improved in the last decades? What are the main causes for morbidity and mortality? And can we reach tolerance in the future? We invite you to give your opinion in the patient cases and to discuss it on the forum. There are also advanced readings to look at additional subjects, including recurrence of the kidney disease after transplantation, the organization of dermatological care for the transplant recipient and the role of the patient himself in the whole process. The interview about tolerance gives you insight why pregnancy is of interest to understand the concept of tolerance and which steps have been made from lab research to a clinical protocol. In the honors lesson late challenges will be discussed in more detail, with a focus on infections, recurrence of the kidney disease after transplantation and tolerance. Have fun and good luck with this last module.
Final Quiz
We hope you have enjoyed all the modules. Good luck with the final quiz! If you are interested in an intensive course about transplantation go to the course resources.

Good to know

Know what's good
, what to watch for
, and possible dealbreakers
Explores clinical kidney, pancreas and islet transplantation, which is an advancement in medicine
Teaches about pre-transplantation procedures, surgical procedures, and post-transplantation challenges
Provides insights on clinical kidney, pancreas and islet transplantation to healthcare professionals, medical students and those interested in the field
Offers hands-on learning opportunities through 3D movies, interactive patient cases, and a serious game
Taught by a multidisciplinary team of transplant professionals, providing comprehensive knowledge and expertise
Endorsed by European Society of Organ Transplantation, International Society of Nephrology and The Transplantation Society
Has partnered with Cape Town University for further study in organ donation transplantation
Students should have some background knowledge in medicine or healthcare

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Reviews summary

Well-received kidney transplant course

Learners say Clinical Kidney, Pancreas and Islet Transplantation is a largely positive course that is highly informative about kidney and pancreas transplantation and offers a variety of quality interactive materials.

Activities

Be better prepared before your course. Deepen your understanding during and after it. Supplement your coursework and achieve mastery of the topics covered in Clinical Kidney, Pancreas and Islet Transplantation with these activities:
Find a mentor in the field of transplantation
Finding a mentor experienced in the field of transplantation will provide the student with guidance and support throughout their learning journey.
Show steps
  • Attend transplantation-related events and conferences
  • Network with professionals in the field
  • Ask for recommendations from faculty or colleagues
Review Immunology Concepts
Refreshes the student's immunology knowledge and will help the student to understand the immunological concepts in the course.
Browse courses on Immunology
Show steps
  • Review and summarize the basic principles of immunology
  • Read a basic immunology textbook or online resources
Participate in a peer-led study group
Participating in a peer-led study group will provide the student with the opportunity to discuss course material with other learners and to teach others, which is a great way to reinforce concepts.
Show steps
  • Find or form a study group with other students in the course
  • Meet regularly to discuss course material
  • Take turns leading the discussion
14 other activities
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Review basic immunology concepts
Strengthens understanding of immunological barriers and tests, which are essential for comprehension of the 'Before the Transplant' module.
Browse courses on Immunology
Show steps
  • Review textbooks or online resources on basic immunology concepts.
  • Practice solving multiple-choice questions or case studies related to immune system functions.
Practice immunology concepts
Help familiarize yourself with the immunological concepts used throughout the course.
Show steps
  • Review the lecture notes on immunology
  • Complete the practice problems on the course website
  • Attend the immunology review session
Watch video tutorials on transplantation techniques
Watching video tutorials on transplantation techniques can help you learn about the latest surgical techniques and best practices.
Browse courses on Kidney Transplantation
Show steps
  • Search for video tutorials on transplantation techniques
  • Watch the tutorials and take notes
Create a digital library of resources
Creating a digital library of resources will provide the student with a centralized location to store and access important course materials and references.
Show steps
  • Gather resources from the course syllabus, textbooks, and other sources
  • Organize the resources into folders or categories
  • Create a digital library using a note-taking app or cloud storage service
Participate in online discussion forums
Fosters interaction with peers, allows for knowledge exchange, and helps clarify concepts discussed in the course, as encouraged in every module.
Show steps
  • Join the course discussion forums.
  • Review the discussion topics and select one to participate in.
  • Share your thoughts, questions, or insights related to the topic.
  • Read and respond to the contributions of your peers.
Explore virtual reality simulations of transplant surgeries
Enhances understanding of surgical procedures and helps visualize the anatomical structures involved, as taught in the 'The Procedure and the Patient' module.
Show steps
  • Access a virtual reality platform that offers transplant surgery simulations.
  • Select a simulation scenario that aligns with the course content.
  • Follow the instructions and perform the virtual surgery, paying attention to the surgical techniques and anatomical landmarks.
  • Review the simulation outcomes and reflect on the challenges encountered.
Attend a peer-led study group on transplantation
Attending a peer-led study group can help you learn from your peers and reinforce your understanding of transplantation.
Show steps
  • Find a peer-led study group on transplantation
  • Attend the study group meetings
  • Participate in discussions and ask questions
Create a Transplantation Journal
Start a journal to document your understanding of the key concepts and challenges in kidney, pancreas, and islet transplantation.
Show steps
  • Establish a regular writing schedule for your journal.
  • Reflect on the modules you have completed and summarize the key takeaways.
  • Research additional information on specific topics that interest you.
  • Share your journal entries with a peer or mentor for feedback.
Attend a transplant surgery workshop
Attending a transplant surgery workshop provides the student with hands-on experience and allows the student to observe the surgical techniques used in transplantation.
Browse courses on Surgical Procedures
Show steps
  • Register for a transplant surgery workshop
  • Attend the workshop
  • Participate in the hands-on activities
Practice surgical procedures using a surgical simulator
Practicing surgical procedures using a simulator can help you improve your surgical skills and confidence, which will be beneficial during transplantation surgeries.
Browse courses on Surgical Procedures
Show steps
  • Familiarize yourself with the surgical simulator
  • Practice basic surgical techniques
  • Practice advanced surgical techniques, such as kidney transplantation
Write a case study analysis
Demonstrates understanding of complex medical cases and patient challenges, as covered in the 'Early Challenges' and 'Late Challenges' modules.
Show steps
  • Choose a complex medical case involving a transplant patient, focusing on early or late challenges.
  • Research and gather information about the case, including medical history, surgical procedures, immunosuppressive therapy, and outcomes.
  • Analyze the case, identifying the challenges faced by the patient and the healthcare team.
  • Develop a written analysis that includes a discussion of the challenges, potential solutions, and evidence-based recommendations.
Design a hypothetical transplant center
Encourages critical thinking about the organization and functioning of a transplant center, as discussed in the 'Before the Transplant' and 'Early Challenges' modules.
Show steps
  • Research different transplant center models and best practices.
  • Develop a floor plan and organizational structure for your hypothetical center.
  • Consider patient care protocols, staffing requirements, and ethical guidelines.
  • Present your design to the class for feedback and discussion.
Patient Case Analysis Exercises
Engage in case analysis exercises to apply your knowledge of transplantation to real-world scenarios.
Show steps
  • Review the patient case provided in the course materials.
  • Identify the key medical issues and challenges presented in the case.
  • Develop a differential diagnosis and treatment plan.
  • Discuss your findings with a peer or mentor.
Develop a research proposal
Taking knowledge of the course and applying it to a research proposal allows the student to delve deeper into a particular area of interest within the field.
Browse courses on Research Methods
Show steps
  • Identify a research question
  • Conduct a literature review
  • Develop a hypothesis
  • Design a research study
  • Write a research proposal

Career center

Learners who complete Clinical Kidney, Pancreas and Islet Transplantation will develop knowledge and skills that may be useful to these careers:
Surgeon
Surgeons perform surgical procedures to treat diseases and injuries. They work on various parts of the body, including the kidneys, pancreas, and islets of Langerhans. This course would be very helpful for someone who wants to become a surgeon specializing in transplantation.
Nephrologist
Nephrologists specialize in the study and treatment of kidney diseases. They work closely with transplant surgeons to care for patients before, during, and after transplantation. This course would be helpful for those who want to become a nephrologist who specializes in transplantation.
Immunologist
Immunologists study the immune system and how it protects the body from infection and disease. They work in a variety of settings, including hospitals, research institutions, and pharmaceutical companies. This course would be helpful for those who want to become an immunologist who specializes in transplantation.
Pharmacist
Pharmacists dispense medications to patients and provide information about their use. They work in a variety of settings, including hospitals, retail pharmacies, and long-term care facilities. This course would be helpful for those who want to become a pharmacist who specializes in transplantation.
Physician Assistant
Physician Assistants provide medical care to patients under the supervision of a physician. They work in a variety of settings, including hospitals, clinics, and long-term care facilities. This course would be helpful for those who want to become a Physician Assistant who specializes in transplantation.
Registered Nurse
Registered Nurses provide direct patient care and work under the supervision of a physician. They work in a variety of settings, including hospitals, clinics, and long-term care facilities. This course would be helpful for those who want to become a Registered Nurse who specializes in transplantation.
Medical Researcher
Medical Researchers conduct research to improve the understanding of diseases and develop new treatments. They work in a variety of settings, including universities, hospitals, and research institutions. This course would be helpful for those who want to become a Medical Researcher who specializes in transplantation.
Biomedical Engineer
Biomedical Engineers design and develop medical devices and technologies. They work in a variety of settings, including hospitals, research institutions, and medical device companies. This course would be helpful for those who want to become a Biomedical Engineer who specializes in transplantation.
Health Educator
Health Educators provide information and education to patients and their families about health and wellness. They work in a variety of settings, including hospitals, clinics, and community health centers. This course would be helpful for those who want to become a Health Educator who specializes in transplantation.
Social Worker
Social Workers provide support and counseling to patients and their families during difficult times. They work in a variety of settings, including hospitals, clinics, and community health centers. This course would be helpful for those who want to become a Social Worker who specializes in transplantation.
Dietitian
Dietitians provide nutrition counseling and advice to patients and their families. They work in a variety of settings, including hospitals, clinics, and community health centers. This course would be helpful for those who want to become a Dietitian who specializes in transplantation.
Patient Advocate
Patient Advocates represent the interests of patients and their families in the healthcare system. They work in a variety of settings, including hospitals, clinics, and health insurance companies. This course would be helpful for those who want to become a Patient Advocate who specializes in transplantation.
Quality Improvement Specialist
Quality Improvement Specialists work to improve the quality of care provided to patients. They work in a variety of settings, including hospitals, clinics, and health insurance companies. This course would be helpful for those who want to become a Quality Improvement Specialist who specializes in transplantation.
Medical Scientist
Medical Scientists are responsible for the study of diseases, development of drugs, and implementation of treatments. They work in conjunction with healthcare professionals, including surgeons, to treat patients. This course may be useful for those interested in the surgical procedures related to kidney, pancreas, and islet transplantation.
Compliance Officer
Compliance Officers ensure that healthcare organizations comply with all applicable laws and regulations. They work in a variety of settings, including hospitals, clinics, and health insurance companies. This course would be helpful for those who want to become a Compliance Officer who specializes in transplantation.

Reading list

We've selected six books that we think will supplement your learning. Use these to develop background knowledge, enrich your coursework, and gain a deeper understanding of the topics covered in Clinical Kidney, Pancreas and Islet Transplantation.
This textbook provides a comprehensive overview of liver transplantation, with sections on the basic principles of liver transplantation, the selection of transplant candidates, the surgical techniques used, and the management of post-transplant complications.
This textbook covers techniques and experimental methodologies for studying human viruses, focusing on the immunology of host-virus interactions, virus-induced cell transformation, and the regulation of cellular responses to viruses.
This textbook serves as a reference for the immunologic concepts underlying the clinical practice of transplantation, including the latest molecular mechanisms involved in allorecognition, immunosuppression, and tolerance.
Provides a comprehensive overview of the immunology of renal transplantation, including the latest research on graft rejection and tolerance. It may be useful for those interested in additional depth of knowledge.
For those seeking an in-depth understanding of kidney transplantation, this book serves as a comprehensive reference guide, covering the entire spectrum of the procedure, from surgical techniques to immunosuppression and long-term outcomes.
Offers a thorough analysis of immunosuppressive therapy, examining the pharmacology and mechanisms of action of different immunosuppressive drugs, monitoring strategies, and side effects. It can serve as a valuable resource for those seeking a deeper understanding of immunosuppression protocols.

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