From Disease to Genes and Back
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Human genetics explores the genetically determined similarities and differences between human beings. This scientific discipline encompasses a variety of related fields such as molecular genetics, genomics, population genetics and medical genetics. Study of human genetics can help to find answers to questions regarding the inheritance and development of different human phenotypes. The field of medical genetics is quickly growing and dynamically developing thanks to the new technologies such as the next-generation sequencing. Most human diseases have a genetic component. This genetic component varies by disease. Some rare diseases appear to be completely determined by the genome, whereas more common diseases arise from a complex interplay of many genes, the environment and chance. The understanding of how our genomes contribute to disease susceptibility offers the prospect of large gains: it may guide disease diagnostics and prognostics and help in developing new therapies. The overall goal of this course is to describe how the researchers find genes responsible for different diseases and how this information is used to better understand and fight these diseases. You will learn about current approaches for finding single genetic variants underlying monogenic (Mendelian) diseases and sets of variants responsible for more complex, multifactorial ones. Furthermore, you will learn how the identification of these genetic variants makes it possible to understand how the affected biological pathways lead to disease development. During the final week of the course, we will talk more about clinical applications of the genetic findings. Upon completing the course, you will be able to: - give examples of monogenic and complex disorders - recognise patterns of Mendelian inheritance of monogenic diseases; - understand and describe principles and methods of gene mapping ; - describe the main steps and principles of genome-wide association studies (GWAS); - give examples of modern technologies that are currently used to find variants underlying human diseases; - discuss the approaches to finding causative variants underlying complex disorders; - discuss the possibilities and areas of application of genetic findings.
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Rating | 4.5★ based on 15 ratings |
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Length | 7 weeks |
Effort | 6 weeks of study, 3-5 hours a week |
Starts | Feb 14 (115 weeks ago) |
Cost | $49 |
From | Novosibirsk State University via Coursera |
Instructors | Yurii Aulchenko, Natalia Aulchenko, Lennart Karssen, Gert Matthijs, Marianna Bevova, Sodbo Sharapov, Michel Georges, Yakov Tsepilov, Alexander Tashkeev |
Download Videos | On all desktop and mobile devices |
Language | English |
Subjects | Science |
Tags | Life Sciences Medicine And Healthcare Biology Basic Science |
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What people are saying
genome wide association studies
It was most fruitful in week 4 about genome wide association studies (GWAS).
полезным возвращаться к нему
Даже после прохождения курса будет полезным возвращаться к нему.
clearer illustrations are definitely
More help and clearer illustrations are definitely needed to complete this course and understand the material It was really helpful for me to refresh my memory and learn additional information.
if certificate will
If Certificate will be free, Thats much better.
get every thing
it's full of beneficial information, but some topics were hardly understandable and some others were quite broad that was hard to get every thing in detail, but I'll keep learning until i understand them.thank you very much, your course was like doors to decide which door is correct choice for me ^_^
keep learning until
количество дополнительного материала
И отдельное спасибо за огромное количество дополнительного материала!
good course
highly recommended
Highly recommended!An interesting, up-to-date course with eye-catching and well designed videos.
more help
believe there´re
Loved the course though I believe there´re some topics that could be explained in a better detail as in the case of population genetics and estimations of some math calculations but in general the course is really great, remarkable lecturers.
correct choice
Careers
An overview of related careers and their average salaries in the US. Bars indicate income percentile.
Genomic Lab Specialist $50k
Clinical Research Liaison/Clinical Research Coordinator, Center for Gene Therapy $58k
Research Specialist (Rodent, Gene Therapy, Molecular, Biochemical) $58k
Genomic Science Liaison $61k
Genomic Technologist $64k
Genomic Variation Specialist $68k
Genomic Data Science Programmer $75k
Genomic Specialist Consultant $76k
Clinical Genetic Counselor $79k
Center for Human Genetic Research $83k
Senior Research Genetic Counselor $84k
Research Genetic Counselor Fellow $88k
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Rating | 4.5★ based on 15 ratings |
---|---|
Length | 7 weeks |
Effort | 6 weeks of study, 3-5 hours a week |
Starts | Feb 14 (115 weeks ago) |
Cost | $49 |
From | Novosibirsk State University via Coursera |
Instructors | Yurii Aulchenko, Natalia Aulchenko, Lennart Karssen, Gert Matthijs, Marianna Bevova, Sodbo Sharapov, Michel Georges, Yakov Tsepilov, Alexander Tashkeev |
Download Videos | On all desktop and mobile devices |
Language | English |
Subjects | Science |
Tags | Life Sciences Medicine And Healthcare Biology Basic Science |
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