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Hacking COVID-19 — Course 1

Identifying a Deadly Pathogen

Niema Moshiri, Vikram Sirupurapu, Sabeel Mansuri, Pavel Pevzner, and Mikhail Rayko

In this course, you will follow in the footsteps of the bioinformaticians investigating the COVID-19 outbreak by assembling the SARS-CoV-2 genome. Whether you’re new to the world of computational biology, or you’re a bioinformatics expert seeking to learn about its applications in the COVID-19 pandemic, or somewhere in between, this course is for you! As you go through this journey, we will introduce and explain genomic concepts and give you many opportunities to practice your skills, and we will provide a series of problems with gradually increasing complexity. This first course will only discuss the assembly of the SARS-CoV-2 genome, but future courses in this series will explore follow-up bioinformatics analyses used in the COVID-19 pandemic.

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What's inside

Syllabus

Week 1
In Chapter 1, we will first travel back in time to learn about the history of the SARS outbreak of 2003. Next, we will travel to late 2019 to learn about the origins of SARS-CoV-2, a novel virus that wreaked havoc upon the world during the COVID-19 pandemic. Lastly, we will explore the biology behind this mysterious virus as we take our first steps towards Hacking COVID-19.
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Week 2
In Chapter 2, we will learn about how modern technologies are able to sequence DNA in small chunks. Next, we will learn how to use SPAdes, a popular genome assembly tool, to reconstruct the SARS-CoV-2 genome from small fragments. Lastly, we will learn how to use QUAST to assess the quality of our assembled SARS-CoV-2 genome.

Good to know

Know what's good
, what to watch for
, and possible dealbreakers
Course belongs to an entire series of courses
Introduces common genomic concepts early on
Introduces modern technologies, such as DNA sequencing
Teaches learners how to use a genome assembly tool
Emphasizes the importance of quality assessment in bioinformatics
Provides multiple opportunities to practice skills

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Reviews summary

Course on covid-19 pathogen detection

learners say this course is a great choice for people looking to learn more about viruses and bioinformatics. It has engaging assignments and a well structured curriculum. Excellent intro to how researchers identify deadly pathogens.
Learners found the course to be highly engaging.
"I​t is really a great cource "
"I​ loved this course, it was challenging what I love and I learned so many new things."
Introduces students to bioinformatics.
"GAVE ME A NEW LEARNING PERSPECTIVE ON BIOINFORMATICS"
"Me encanto la interacción con los ejercicios de bioinformática."
Learners felt that the course covered difficult material.
"Interesting course but not knowing the bio-informatics involved kind of bummed it out for me."

Activities

Coming soon We're preparing activities for Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen. These are activities you can do either before, during, or after a course.

Career center

Learners who complete Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen will develop knowledge and skills that may be useful to these careers:
Bioinformatician
A Bioinformatician studies the overlap between computer science and biology, applying the principles of computer science and informatics to biological systems. They research and develop applications and methods for analyzing and understanding the vast amounts of data generated in the life sciences. This course, Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen, may be useful because it discusses the assembly of the SARS-CoV-2 genome. It can help build a foundation for understanding the uses and possibilities of bioinformatics in the medical industry.
Computational Biologist
A Computational Biologist is a scientist who uses computer science techniques to understand biological data. Computational Biology combines computer science, applied mathematics, statistics, and engineering to analyze and interpret biological data. This course, Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen, may be useful because it discusses the assembly of the SARS-CoV-2 genome. It can help build a foundation for understanding the uses and possibilities of computational biology in the medical industry.
Medical Scientist
A Medical Scientist will typically have an advanced degree in a biomedical field. They work in medical research and development to advance knowledge and improve human health. This course, Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen, may be useful because it discusses the assembly of the SARS-CoV-2 genome, which could lay the foundation for a research project.
Genetic Counselor
Genetic Counselors help people understand and make informed decisions about genetic conditions. They work with patients and their families to provide information about the risks and benefits of genetic testing, and help them to develop a plan for managing their genetic health. This course, Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen, may be useful because it discusses the assembly of the SARS-CoV-2 genome. It also introduces and explains genomic concepts, which could help genetic counselors better understand the genetic aspects of the COVID-19 pandemic.
Virologist
Virologists study viruses, which are small infectious agents that can cause disease in humans, animals, and plants. They research the structure, function, and genetics of viruses, and how they interact with their hosts. This course, Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen, may be useful because it discusses the assembly of the SARS-CoV-2 genome. This is a critical step in understanding and treating the virus. By completing this course, virologists can gain a deeper understanding of the virus and develop more effective strategies to combat it.
Epidemiologist
Epidemiologists study the distribution and patterns of disease in a population. They use this information to develop and implement public health interventions to prevent and control disease outbreaks. This course, Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen, may be useful because it discusses the assembly of the SARS-CoV-2 genome. This could help epidemiologists better understand how the virus spreads and develop effective control measures.
Biomedical Engineer
Biomedical Engineers apply engineering principles and techniques to the medical field. They design and develop medical devices, implants, and other technologies to improve human health. This course, Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen, may be useful because it discusses the assembly of the SARS-CoV-2 genome, which is a critical step in understanding and treating the virus. By completing this course, biomedical engineers can gain a deeper understanding of the virus and develop more effective technologies to combat it.
Researcher
Research Scientists design, conduct, and analyze studies to advance knowledge in their field. They may work in a variety of settings, including universities, government agencies, and private companies. This course, Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen, may be useful because it discusses the assembly of the SARS-CoV-2 genome. This could help researchers better understand how viruses work and develop new treatments and vaccines for infectious diseases.
Microbiologist
Microbiologists study microorganisms, such as bacteria, viruses, and fungi. They research the growth, reproduction, and genetics of microorganisms, and how they affect human health and the environment. This course, Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen, may be useful because it discusses the assembly of the SARS-CoV-2 genome, which is a critical step in understanding and treating the virus. By completing this course, microbiologists can gain a deeper understanding of the virus and develop more effective strategies to combat it.
Physician
Physicians are responsible for providing medical care to patients. They diagnose and treat diseases, perform surgeries, and conduct research. This course, Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen, may be useful because it discusses the assembly of the SARS-CoV-2 genome, which could help provide a deeper understanding of bioinformatics and its uses in the medical field.
Computer Scientist
Computer Scientists research and develop new computing technologies. They work in a variety of fields, including artificial intelligence, computer graphics, and software engineering. This course, Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen, may be useful because it discusses the assembly of the SARS-CoV-2 genome. This could help computer scientists develop new methods for analyzing and interpreting biological data.
Software Engineer
Software Engineers design, develop, and maintain software systems. They work with users to gather requirements, design and implement software solutions, and test and debug software. This course, Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen, may be useful because it discusses the assembly of the SARS-CoV-2 genome. This could help software engineers develop new tools and applications for tracking and analyzing the spread of the virus.
Biostatistician
Biostatisticians apply statistical methods to solve problems in biology and medicine. They work with researchers to design studies, analyze data, and interpret results. This course, Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen, may be useful because it discusses the assembly of the SARS-CoV-2 genome. This could help biostatisticians develop new methods for analyzing and interpreting data on the spread and treatment of the virus.
Data Analyst
Data Analysts collect, clean, and analyze data to identify trends and patterns. They use their findings to make recommendations and inform decision-making. This course, Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen, may be useful because it discusses the assembly of the SARS-CoV-2 genome. This could help data analysts develop new methods for tracking and analyzing the spread of the virus.
Pharmacist
Pharmacists dispense medications and provide information about their use. They also work with physicians to develop and manage medication plans for patients. This course, Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen, may be useful for pharmacists. It can provide them with a deeper understanding of the SARS-CoV-2 virus and how it can be treated. This knowledge can help pharmacists provide better care to their patients and help to prevent the spread of the virus.

Reading list

We've selected eight books that we think will supplement your learning. Use these to develop background knowledge, enrich your coursework, and gain a deeper understanding of the topics covered in Hacking COVID-19 — Course 1: Identifying a Deadly Pathogen.
Provides a comprehensive overview of molecular biology. It valuable resource for students and researchers who want to understand the fundamental principles of biology.
Introduces the fundamental principles of reproducible and robust research in bioinformatics. It provides a comprehensive overview of open source tools and workflows commonly used in the field.
Provides a comprehensive overview of genomics. It valuable resource for students and researchers who want to understand the structure and function of genomes.
Provides a comprehensive overview of genome analysis. It valuable resource for students and researchers who want to understand the methods used to analyze genomes.
Provides a comprehensive overview of human molecular genetics. It valuable resource for students and researchers who want to understand the genetic basis of human health and disease.
Provides a practical guide to bioinformatics, with a focus on hands-on exercises and case studies. It will be particularly useful for learners who want to develop the practical skills necessary to use bioinformatics tools and techniques.
Provides a comprehensive overview of bioinformatics. It good resource for students and researchers who are new to the field.
Provides a gentle introduction to bioinformatics. It good resource for students and researchers who are new to the field.

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