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Introduction to Systems Biology

This course is part of a Specialization (series of courses) called Systems Biology and Biotechnology.

This course will introduce the student to contemporary Systems Biology focused on mammalian cells, their constituents and their functions. Biology is moving from molecular to modular. As our knowledge of our genome and gene expression deepens and we develop lists of molecules (proteins, lipids, ions) involved in cellular processes, we need to understand how these molecules interact with each other to form modules that act as discrete functional systems. These systems underlie core subcellular processes such as signal transduction, transcription, motility and electrical excitability. In turn these processes come together to exhibit cellular behaviors such as secretion, proliferation and action potentials. What are the properties of such subcellular and cellular systems? What are the mechanisms by which emergent behaviors of systems arise? What types of experiments inform systems-level thinking? Why do we need computation and simulations to understand these systems?

The course will develop multiple lines of reasoning to answer the questions listed above. Two major reasoning threads are: the design, execution and interpretation of multivariable experiments that produce large data sets; quantitative reasoning, models and simulations. Examples will be discussed to demonstrate “how” cell- level functions arise and “why” mechanistic knowledge allows us to predict cellular behaviors leading to disease states and drug responses.

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Icahn School of Medicine at Mount Sinai

Rating 3.8 based on 50 ratings
Length 11 weeks
Effort 6-8 hours/week
Starts Dec 10 (2 days ago)
Cost $49
From Icahn School of Medicine at Mount Sinai via Coursera
Instructors , Ravi Iyengar, PhD
Free Limited Content
Language English
Subjects Science
Tags Life Sciences Biology

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What people are saying

We analyzed reviews for this course to surface learners' thoughts about it

systems biology in 12 reviews

Don't expect to walk away from the course with a complete grasp of systems biology.

Thanks a lot Indeed the course has provided me an introduction to different basic aspects of Systems Biology such as different experimental technologies and computational models.

The course has great content, truly a powerful introduction to many aspects and concepts of systems biology.

Good overview of systems biology, but the graded tests are somewhat difficult to understand for someone without a biology background such as myself.

An excellent introduction to Systems Biology.

There are actually many parallels with systems biology and engineering, so most of the material was intuitive or could be easily fitted with my previous knowledge.

It is a good introductory course, but it relies too much on networks and could be confusing and demoralizing if you intend to pursue a career in systems biology.

It's a great overview, but somehow i didn't feel like it stuck even though i did put in effort to read the articles assigned starting halfway through the course.Maybe it's because there's so much material that will be covered in a hands on part in the 3rd and 4th parts of this specialization... Would definitely recommend it to everyone interested in biotechnology and systems biology.

so much in 3 reviews

Thanks so much!

Nice course, a little boring at the beginning with so much data about cell signaling, (kinases names, and specific routes).

hard for in 3 reviews

a bit to hard for an introduction cours 3rd week and I am loving it!

What I am highlighting is that his teaching style will be hard for some course takers to follow.

There are multiple severe issues with this course: The content is very hard for an introductory one (you need at least know a lot of details of cell biology, metabolism, see e.g.

molecular biology in 2 reviews

It is definitely an advantage to have studied biochemistry and molecular biology beforehand.

Even though I knew some bits and pieces about molecular biology, I still found this course hard to follow.

This course needs some basic expertise in molecular biology to be useful.

very good in 2 reviews

It was a very good course.

I didn't give it five stars just because the quality of the audio wasn't very good sometimes and it's hard to listen unless you use headphones.

very good Ravi is a great researcher.

Careers

An overview of related careers and their average salaries in the US. Bars indicate income percentile (33rd - 99th).

Cellular Network Technician $68k

Cellular Technician $69k

Senior Cellular Field Engineer $93k

Cellular Field Engineer $95k

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Coursera

&

Icahn School of Medicine at Mount Sinai

Rating 3.8 based on 50 ratings
Length 11 weeks
Effort 6-8 hours/week
Starts Dec 10 (2 days ago)
Cost $49
From Icahn School of Medicine at Mount Sinai via Coursera
Instructors , Ravi Iyengar, PhD
Free Limited Content
Language English
Subjects Science
Tags Life Sciences Biology

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