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Experimental Methods in Systems Biology

Systems Biology and Biotechnology,

Learn about the technologies underlying experimentation used in systems biology, with particular focus on RNA sequencing, mass spec-based proteomics, flow/mass cytometry and live-cell imaging. A key driver of the systems biology field is the technology allowing us to delve deeper and wider into how cells respond to experimental perturbations. This in turns allows us to build more detailed quantitative models of cellular function, which can give important insight into applications ranging from biotechnology to human disease. This course gives a broad overview of a variety of current experimental techniques used in modern systems biology, with focus on obtaining the quantitative data needed for computational modeling purposes in downstream analyses. We dive deeply into four technologies in particular, mRNA sequencing, mass spectrometry-based proteomics, flow/mass cytometry, and live-cell imaging. These techniques are often used in systems biology and range from genome-wide coverage to single molecule coverage, millions of cells to single cells, and single time points to frequently sampled time courses. We present not only the theoretical background upon which these technologies work, but also enter real wet lab environments to provide instruction on how these techniques are performed in practice, and how resultant data are analyzed for quality and content.

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Rating 4.3 based on 37 ratings
Length 9 weeks
Effort 6-8 hours/week
Starts Jul 5 (16 weeks ago)
Cost $49
From Icahn School of Medicine at Mount Sinai via Coursera
Instructor Marc Birtwistle, PhD
Download Videos On all desktop and mobile devices
Language English
Subjects Science
Tags Life Sciences Biology Research

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What people are saying

very good

:) its very good.

very good introduction but as i go through the videos and then do the quiz i feel like the material doesn't highlight exactly what is needed for the quiz.

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good course

Great course,Recommended if you are interest in new technologies A good course for someone interested to work in the field of systems biology, and thanks to Icahn School of Medicine and Coursera for the same.But the course could have been a bit more comprehensive with respect to cellular experiments and include coverage of experiments done outside the Mount Sinai lab as well, especially 'non-omic' experiments such as cell growth and viability assays or KD , KO or Over-Expression studies that can be really useful for building network models.

Excelente Really good course, even though the test were so unfair with the multiple choice questions.

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Rating 4.3 based on 37 ratings
Length 9 weeks
Effort 6-8 hours/week
Starts Jul 5 (16 weeks ago)
Cost $49
From Icahn School of Medicine at Mount Sinai via Coursera
Instructor Marc Birtwistle, PhD
Download Videos On all desktop and mobile devices
Language English
Subjects Science
Tags Life Sciences Biology Research

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