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Drug Discovery

Joseph D. Ma and Williams S. Ettouati, Pharm.D.

The University of California San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences Drug Discovery course brings you lectures from both faculty and industry experts. With this course, recorded on campus at UCSD, we seek to share our access to top people in the field who bring an unprecedented range of expertise on drug discovery.

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The University of California San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences Drug Discovery course brings you lectures from both faculty and industry experts. With this course, recorded on campus at UCSD, we seek to share our access to top people in the field who bring an unprecedented range of expertise on drug discovery.

In this course you will learn the drug discovery process up to the filing of an Initial New Drug Application or IND. Each week you will learn the steps that a pharmaceutical or biotech company goes through to discover a new therapeutic drug. In this course you will be able to:

* Understand the pharmaceutical and biotechnology market a changing landscape

* Learn the major aspects of the drug discovery process, starting with target selection, to compound screening to designing lead candidates.

* Recognize current modern drug discovery based on the lock-and-key theory, which attempts to use one single compound to hit one target to combat the related disease.

* Increase understanding of the various drug discovery tools and methods that are used for finding, identifying and designing a new drug.

* Define and understand the regulatory responsibilities for drug discovery to file an Investigational New Drug Application (IND).

This course is intended as part 1 of a series: Drug Discovery, Drug Development (https://www.coursera.org/learn/drug-development) and Drug Commercialization (https://www.coursera.org/learn/drug-commercialization). We would highly recommend that you take the courses in order since it will give you a better understanding on how a drug is discovered in the lab before being tested in clinical trials and then launched in the market place.

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What's inside

Syllabus

Welcome!
Pharmaceutical & Biotechnology Industry Landscape
In this module course lead Dr. Williams Ettouati begins by giving a landscape overview of the Pharma and Biotechnology landscape.
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Drug Discovery: Proteomics, Genomics
This week we will be hearing from Phillip Bourne, PhD. Dr. Bourne was, at the time of this recording, the Associate Vice Chancellor for Innovation and Industrial Alliances in the UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences. Since that time, he has been named the first Associate Director for Data Science at the United States National Institutes of Health.
Compound Selection & Preclinical Studies
This week we will hear from Ronald Christopher, Ph.D. Dr. Ronald Christopher, Vice President of Preclinical Trials at Arena Pharmaceuticals.
Challenges in Fragment Based Drug Discovery for Protein Kinases
In this module we will hear from Stephen Burley, M.D., Ph.D. At the time of this recording, Director of the Center for Integrative Proteomics at Rutgers University. He is now the Director of the Protein Data Bank and remains an Adjunct Professor at the UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences.
Key Concepts in Drug Delivery
This module we hear from Professor of Clinical Pharmacy and Pediatrics, Brookie Best, Pharm. D., of UCSD's Skaggs School of Pharmacy and Pharmaceutical Sciences.

Good to know

Know what's good
, what to watch for
, and possible dealbreakers
Lays groundwork in drug discovery processes
Provides expert perspectives from both faculty and industry professionals
Covers key aspects of drug discovery up to filing an IND
Part of a series on drug development and commercialization

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Reviews summary

Drug discovery: mixed reviews

According to students, Drug Discovery has brief lectures and little explanation which some learners find disappointing and boring. Yet, others report finding the course to be informative with some interesting topics.

Activities

Coming soon We're preparing activities for Drug Discovery . These are activities you can do either before, during, or after a course.

Career center

Learners who complete Drug Discovery will develop knowledge and skills that may be useful to these careers:
Research Scientist
Research Scientists conduct research to discover new drugs and therapies. They work in the pharmaceutical industry and use their knowledge of biology, chemistry, and pharmacology to identify and develop new drug candidates. The Drug Discovery course from the University of California, San Diego will teach you about the drug discovery process, which will be helpful if you want to work as a research scientist. Additionally, this course will help you to understand the regulatory process for new drugs, which is essential for anyone working in the pharmaceutical industry.
Drug Discovery Scientist
Drug Discovery Scientists are responsible for discovering new drugs and therapies. They work in the pharmaceutical industry and use their knowledge of biology, chemistry, and pharmacology to identify and develop new drug candidates. The Drug Discovery course from the University of California, San Diego will teach you about the drug discovery process, which will be helpful if you want to work in drug discovery. Additionally, this course will help you to understand the regulatory process for new drugs, which is essential for anyone working in the pharmaceutical industry.
Pharmacologist
Pharmacologists study the effects of drugs on the body. They use their knowledge to develop new drugs and therapies. The Drug Discovery course from the University of California, San Diego will teach you about the drug discovery process, which will be helpful if you want to work as a pharmacologist. Additionally, this course will help you to understand the regulatory process for new drugs, which is essential for anyone working in the pharmaceutical industry.
Pharmaceutical Sales Representative
Pharmaceutical Sales Representatives sell drugs and other pharmaceutical products to healthcare professionals. They provide information about the clinical trials, safety, and efficacy of new drugs. The Drug Discovery course from the University of California, San Diego will teach you about the drug discovery process, which will be helpful if you want to work as a pharmaceutical sales representative. Additionally, this course will help you to understand the regulatory process for new drugs, which is essential for anyone working in the pharmaceutical industry.
Medical Science Liaison
Medical Science Liaisons work with healthcare professionals to educate them about new drugs and therapies. They provide information about the clinical trials, safety, and efficacy of new drugs. The Drug Discovery course from the University of California, San Diego will teach you about the drug discovery process, which will be helpful if you want to work as a medical science liaison. Additionally, this course will help you to understand the regulatory process for new drugs, which is essential for anyone working in the pharmaceutical industry.
Clinical Research Associate
Clinical Research Associates work with doctors and other healthcare professionals to design, conduct, and manage clinical trials. They ensure that clinical trials are conducted ethically and in accordance with Good Clinical Practice (GCP) guidelines. The Drug Discovery course from the University of California, San Diego will teach you about the drug discovery process, which will be helpful if you want to work in clinical research. Additionally, this course will help you to understand the regulatory process for new drugs, which is essential for anyone working in clinical research.
Regulatory Affairs Specialist
Regulatory Affairs Specialists ensure that drugs and other medical products are safe and effective. They work with the FDA and other regulatory agencies to ensure that drugs meet all safety and efficacy requirements. The Drug Discovery course from the University of California, San Diego will teach you about the drug discovery process, which will be helpful if you want to work as a regulatory affairs specialist. Additionally, this course will help you to understand the regulatory process for new drugs, which is essential for anyone working in the pharmaceutical industry.
Quality Assurance Specialist
Quality Assurance Specialists ensure that drugs and other medical products are safe and effective. They work with the FDA and other regulatory agencies to ensure that drugs meet all safety and efficacy requirements. The Drug Discovery course from the University of California, San Diego will teach you about the drug discovery process, which will be helpful if you want to work as a quality assurance specialist. Additionally, this course will help you to understand the regulatory process for new drugs, which is essential for anyone working in the pharmaceutical industry.
Biostatistician
Biostatisticians use statistical methods to analyze data in the biomedical field. They work in the pharmaceutical industry and use their knowledge of statistics to design and analyze clinical trials. The Drug Discovery course from the University of California, San Diego will teach you about the drug discovery process, which will be helpful if you want to work as a biostatistician. Additionally, this course will help you to understand the regulatory process for new drugs, which is essential for anyone working in the pharmaceutical industry.
Physician
Physicians diagnose and treat diseases. They prescribe drugs and other treatments to patients. The Drug Discovery course from the University of California, San Diego will teach you about the drug discovery process, which will be helpful if you want to work as a physician. Additionally, this course will help you to understand the regulatory process for new drugs, which is essential for anyone working in the healthcare field.
Chemist
Chemists study the structure, properties, composition, and change of matter. They use their knowledge to develop new products and technologies. The Drug Discovery course from the University of California, San Diego will teach you about the principles of drug discovery, which will be helpful if you want to develop new drugs or work in the pharmaceutical industry.
Toxicologist
Toxicologists study the effects of chemicals on the body. They use their knowledge to develop new drugs and therapies. The Drug Discovery course from the University of California, San Diego will teach you about the drug discovery process, which will be helpful if you want to work as a toxicologist. Additionally, this course will help you to understand the regulatory process for new drugs, which is essential for anyone working in the pharmaceutical industry.
Healthcare Consultant
Healthcare Consultants provide advice and guidance to healthcare organizations on a variety of topics, including drug discovery. They help healthcare organizations to improve their efficiency and effectiveness. The Drug Discovery course from the University of California, San Diego will teach you about the drug discovery process, which will be helpful if you want to work as a healthcare consultant in the pharmaceutical industry.
Veterinarian
Veterinarians diagnose and treat diseases in animals. They prescribe drugs and other treatments to animals. The Drug Discovery course from the University of California, San Diego will teach you about the drug discovery process, which will be helpful if you want to work as a veterinarian. Additionally, this course will help you to understand the regulatory process for new drugs, which is essential for anyone working in the veterinary field.
Biomedical Engineer
Biomedical Engineers blend engineering with biology and medicine. They seek new ways to bring technology into the healthcare field by designing tools, devices, systems, and software. They can also work in the pharmaceutical industry. The Drug Discovery course from the University of California, San Diego will introduce you to the drug discovery process, which will be helpful if you want to design new medical technologies. Additionally, this course will help you to understand the regulatory process for new drugs, which could be helpful if you want to work in the pharmaceutical industry.

Reading list

We've selected 12 books that we think will supplement your learning. Use these to develop background knowledge, enrich your coursework, and gain a deeper understanding of the topics covered in Drug Discovery .
This textbook provides comprehensive coverage of medicinal chemistry, including drug discovery, design, and development.
Provides a comprehensive overview of pharmacology, including drug mechanisms of action, pharmacokinetics, and pharmacodynamics, complementing the course's focus on drug discovery and development.
Provides an overview of the drug discovery and development process, including target identification, lead optimization, and clinical trials.
Provides a thorough grounding in molecular biology, which is essential for understanding the molecular basis of drug discovery and development.
Offers a comprehensive overview of biochemistry, providing a strong foundation for understanding the molecular mechanisms of drug action.
Provides a comprehensive overview of pharmaceutical calculations, including dosage calculations, drug concentrations, and pharmacokinetic parameters, complementing the course's focus on preclinical studies and drug development.
Offers a comprehensive overview of the biotechnology industry and its applications in drug discovery, complementing the course's focus on the pharmaceutical industry.
Provides a comprehensive overview of pharmaceutical regulatory science, including drug approval processes and regulatory compliance, complementing the course's discussion of filing an Investigational New Drug Application.
Offers a comprehensive overview of biotechnology, exploring its role in drug discovery and development, providing additional context for the course's focus on the pharmaceutical and biotechnology industry landscape.

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