Targets, Assays & Screening
This course focuses on the early stages of drug discovery and the identification of promising compounds with which to begin the hunt for a novel drug. Different types of assays and methods are reviewed that are used to screen libraries of molecules in the preliminary search for compounds with activity. Methods are discussed for validating that active molecules are indeed engaging a target associated with a predicted therapeutic benefit.
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This course focuses on the early stages of drug discovery and the identification of promising compounds with which to begin the hunt for a novel drug. Different types of assays and methods are reviewed that are used to screen libraries of molecules in the preliminary search for compounds with activity. Methods are discussed for validating that active molecules are indeed engaging a target associated with a predicted therapeutic benefit.
This course focuses on the early stages of drug discovery and the identification of promising compounds with which to begin the hunt for a novel drug. Different types of assays and methods are reviewed that are used to screen libraries of molecules in the preliminary search for compounds with activity. Methods are discussed for validating that active molecules are indeed engaging a target associated with a predicted therapeutic benefit.
Target audience: This course is suitable for life scientists, clinicians, and individuals from fields that support drug discovery (e.g., patents, finance, licensing, etc.) interested in learning more about the pharmaceutical/biotechnology sector. Advanced undergraduate coursework or practical familiarity/working knowledge in biological sciences and organic chemistry is recommended.
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Syllabus
Targets, Assays & Screening, part 1
Welcome, by the end of the course students will be able to: Recognize the differences between target-based and phenotypic drug discovery. Differentiate between common library types and screening approaches for identifying small molecule hits. Describe some of the assay types used in early screening and factors to consider in their design.
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Syllabus
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Activities
Review background in organic chemistry
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This course requires a background in organic chemistry. This will reactivate those neural pathways, making it easier for you to learn this course material.
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Organic Chemistry
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Review notes and textbooks
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Complete practice problems
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Attend review sessions
Review 'Medicinal Chemistry: An Introduction'
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This introductory textbook provides a comprehensive overview of medicinal chemistry. It will provide you with a strong foundation on which to build your knowledge in this course.
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Medicinal Chemistry
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Read assigned chapters in the textbook
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Take notes and highlight key concepts
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Complete end-of-chapter questions
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Attend guest lectures
Organize your notes and study materials
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Taking the time to organize your materials will make it easier for you to study for exams and review the material later.
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Gather all of your notes, handouts, and other materials
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Organize your materials into a logical order
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Create a study schedule
Two other activities
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Practice solving drug design problems
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Solving practice problems will help you develop your problem-solving skills and improve your understanding of the material.
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Find practice problems
-
Solve the problems
-
Check your answers
-
Review your mistakes
Answer questions on discussion forums
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Helping others by answering their questions will help reinforce your knowledge on the subject.
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Find discussion forums related to the course material
-
Answer questions that other students post
-
Review the answers of other students
Review background in organic chemistry
Show steps
This course requires a background in organic chemistry. This will reactivate those neural pathways, making it easier for you to learn this course material.
Browse courses on
Organic Chemistry
Show steps
- Review notes and textbooks
- Complete practice problems
- Attend review sessions
Review 'Medicinal Chemistry: An Introduction'
Show steps
This introductory textbook provides a comprehensive overview of medicinal chemistry. It will provide you with a strong foundation on which to build your knowledge in this course.
View
Medicinal Chemistry
on Amazon
Show steps
- Read assigned chapters in the textbook
- Take notes and highlight key concepts
- Complete end-of-chapter questions
- Attend guest lectures
Organize your notes and study materials
Show steps
Taking the time to organize your materials will make it easier for you to study for exams and review the material later.
Show steps
- Gather all of your notes, handouts, and other materials
- Organize your materials into a logical order
- Create a study schedule
Practice solving drug design problems
Show steps
Solving practice problems will help you develop your problem-solving skills and improve your understanding of the material.
Show steps
- Find practice problems
- Solve the problems
- Check your answers
- Review your mistakes
Answer questions on discussion forums
Show steps
Helping others by answering their questions will help reinforce your knowledge on the subject.
Show steps
- Find discussion forums related to the course material
- Answer questions that other students post
- Review the answers of other students
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