In this course about measuring biological activity, students will learn different methods of activity measurement encountered at different stages of a drug program. The three-week course starts with an introduction to drug targets, which are biological molecules affected by drugs. The second week emphasizes biochemical, cellular, and computational methods for determining the extent to which a drug can affect the action of its target and associated signal pathways. In the final week, students will transition to in vivo studies and the interpretation of dose-response curves.
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In this course about measuring biological activity, students will learn different methods of activity measurement encountered at different stages of a drug program. The three-week course starts with an introduction to drug targets, which are biological molecules affected by drugs. The second week emphasizes biochemical, cellular, and computational methods for determining the extent to which a drug can affect the action of its target and associated signal pathways. In the final week, students will transition to in vivo studies and the interpretation of dose-response curves.
In this course about measuring biological activity, students will learn different methods of activity measurement encountered at different stages of a drug program. The three-week course starts with an introduction to drug targets, which are biological molecules affected by drugs. The second week emphasizes biochemical, cellular, and computational methods for determining the extent to which a drug can affect the action of its target and associated signal pathways. In the final week, students will transition to in vivo studies and the interpretation of dose-response curves.
Students in the course should understand the concepts of proteins and biological pathways. Students should also be comfortable with algebraic expressions, including logarithmic functions. The course is designed in modules. Each module opens with a short video on a selected topic. The module continues with a short reading or exercise with an assessment activity. Each module will require approximately 1 hour to complete, and the course includes 15 modules. Two approaches to the course are recommended. One, a student might spend an hour per day on the course and complete all 15 modules in approximately three weeks. Two, a student with additional available time may be able to work through the entire course in just a single week or over an extended weekend.
Students signed up for the Audit Track have access to the instructional video materials. Students enrolled through the Verified Track have access to the instructional videos, the readings and activities, the assessments, as well as selected additional videos related to the primary instructional videos.
What you'll learn
the general idea of target-based drug discovery, in which a drug’s action on a target alters the function of a biological pathway
common types of biological molecules that serve as drug targets, especially enzymes and receptors
different outcomes of drug-target interactions, including inhibitors, agonists, inverse agonists, and antagonists
representative biochemical and cellular methods for measuring drug-target binding
types of outcomes used to determine the success of clinical trials
the generation and interpretation of dose-response curves
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Activities
Practice drug target binding calculations
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Enhance your understanding of drug-target binding by solving practice problems.
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Review the concept of drug-target binding
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Solve practice problems involving binding constants and affinities
Compile a database of drug targets
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Strengthen your knowledge of different drug targets by creating a comprehensive database.
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Drug Targets
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Research and identify various types of drug targets
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Extract relevant information from scientific literature and databases
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Organize and categorize the drug targets in a structured manner
Develop a model for a novel drug-target interaction
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Deepen your understanding of drug-target interactions by creating a computational model.
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Identify a specific drug-target pair and research its mechanism of action
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Select appropriate software and algorithms for modeling the interaction
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Calibrate and validate the model using experimental data
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Analyze the results and draw conclusions about the interaction
Show all three activities
Practice drug target binding calculations
Show steps
Enhance your understanding of drug-target binding by solving practice problems.
Show steps
- Review the concept of drug-target binding
- Solve practice problems involving binding constants and affinities
Compile a database of drug targets
Show steps
Strengthen your knowledge of different drug targets by creating a comprehensive database.
Browse courses on
Drug Targets
Show steps
- Research and identify various types of drug targets
- Extract relevant information from scientific literature and databases
- Organize and categorize the drug targets in a structured manner
Develop a model for a novel drug-target interaction
Show steps
Deepen your understanding of drug-target interactions by creating a computational model.
Show steps
- Identify a specific drug-target pair and research its mechanism of action
- Select appropriate software and algorithms for modeling the interaction
- Calibrate and validate the model using experimental data
- Analyze the results and draw conclusions about the interaction
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