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Henk Noorman,
Adrie Straathof,
Cees Haringa,
John Posada Duque,
Ludovic Jourdin,
Patricia Osseweijer,
and
Wouter van Winden
Industrial fermentation is the central operation in a broad, sustainable value chain, also involving the upstream generation and supply of renewable feedstocks, and downstream purification of the products formed.
Read more
Industrial fermentation is the central operation in a broad, sustainable value chain, also involving the upstream generation and supply of renewable feedstocks, and downstream purification of the products formed.
Read more
Industrial fermentation is the central operation in a broad, sustainable value chain, also involving the upstream generation and supply of renewable feedstocks, and downstream purification of the products formed.
In this course you will understand how the essential process inputs and outputs are connected via biological and physical mechanisms, and form the basis of process design, scrutiny, optimization and scaling between factory and lab.
This course provides the insights and tools for designing industrial fermentation processes with sustainability advantages, where choices of product and feedstock determine the specific process requirements. Six experienced course leaders will reveal the essentials of industrial fermentation and how to apply these for conceptual design and quantification, resulting in basic mathematical frames and models. Throughout the course, you will apply the theory to a case study where you will produce the building block 1,3-propane diol (PDO) from sugar. Also, you will experience what are the main pitfalls (‘banana skins’) and how to stay away from them.
The course includes guest lectures from industry and universities.
This course is geared towards Biologists, Biotechnologists and Chemical and Environmental Engineers, but will also be of value to others with a different science and engineering background or interest, working in the field of research, development and manufacturing, who wish to deepen their knowledge of industrially relevant fermentation technology and operations.
Register for this course and see more details by visiting:
OpenCourser.com/course/oqa1x5/industrial
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What's inside
Learning objectives
- Apply the insights to suggest improvements for industrial fermentation processes and design of down-scaled lab-scale simulators
- After this course all learners will be in a position to:
- Describe the essence of industrial fermentation
- Utilize insights gained to design an industrial scale quantitative fermentation plant
- Explain the causes and remedies for scale-up issues, from lab to factory
- Apply the insights to suggest improvements for industrial fermentation processes and design of down-scaled lab-scale simulators
- After this course all learners will be in a position to:
- Describe the essence of industrial fermentation
- Utilize insights gained to design an industrial scale quantitative fermentation plant
- Explain the causes and remedies for scale-up issues, from lab to factory
Syllabus
Getting started and introduction is included in Week 1
Unit 1. Industrial Fermentation
Industrial Fermentation: the Great Adventure?
Industrial Fermentation Essentials (preliminary title)
Read more
Syllabus
Getting started and introduction is included in Week 1
Unit 1. Industrial Fermentation
Industrial Fermentation: the Great Adventure?
Industrial Fermentation Essentials (preliminary title)
Read more
Benefits for society and sustainability - evaluating the effects of biobased production (preliminary title)
Process to produce bio-PDO (1,3-Propanediol)
Renewable Feedstocks for Fermentation (preliminary title)
Unit 2. Balances and Microbial Rates
Microorganisms and their function in nature
Functional understanding of nutrient requirements for microbial growth
Learning about the process: broth balances
Learning about the process: gas-phase balances
Learning about the microorganism: q-rates and chemostat
Learning about the process and organism: batch
Extra guest lecture: balances
Extra: banana skins
PDO case
Best practice: mixed cultures
Unit 3. The Black Box Model and Process Reaction
The process reaction
Basics of the black box model
Energy consuming and energy producing products
A PDO black box model: experiments for parameter identification
Black box models: The PDO process reaction as function of μ
PDO continuous process design: calculation of inputs and outputs using the process reaction
Aerobic PDO process: improving sustainability
Introduction to Metabolic Flux Analysis
Best practice: succinic acid
Unit 4. Fermentation Design
Introduction to fermentation technology
The large-scale fermenter
Fermenter operation
Gas transport
Heat transport
Mixing
Basic approach to design and then optimize a PDO fermentation process
Best practice: artemisinin
Unit 5. Scale-down and Scale-up
Introduction to scale-effects
Similarity and scaling approaches
Scaling Macro- Micro-balances
Dimensional scaling
Computational fluid dynamics for scaling
Industrial examples
Unit 6. Wrap-up
Closing lecture: Industrial Fermentation: where we are now, and where we will go?
Final assessment
Good to know
Good to know
Know what's good ,
what to watch for , and
possible dealbreakers
Provides foundational knowledge of industrial fermentation processes, making it suitable for beginners seeking an introduction to the field
The course is designed for individuals with a science or engineering background, ensuring relevance to their existing knowledge and skills
Taught by experienced course leaders with expertise in industrial fermentation, ensuring high-quality instruction and practical insights
Emphasizes the design and optimization of industrial fermentation processes, catering to those interested in developing these skills
Provides a comprehensive overview of the field, covering essential aspects such as feedstocks, products, and process design
Equips learners with the knowledge and tools to evaluate and improve industrial fermentation processes, addressing a practical industry need
Save this course
Save Industrial Fermentation to your list so you can find it easily later:
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Save
Activities
Be better prepared
before
your course. Deepen your understanding
during
and
after
it. Supplement your coursework and achieve mastery of the topics covered
in Industrial Fermentation with these
activities:
Review basic cell and microbiology topics
Show steps
Ensure that your understanding of basic cell and microbiology topics is sound to prepare for more advanced concepts covered in this course.
Show steps
-
Review cell structure and function
-
Review microbial growth and metabolism
Compile a Fermentation Resource Collection
Show steps
Gathers and organizes valuable resources to support further learning and exploration of fermentation processes.
Show steps
-
Search for and collect articles, books, videos, and online resources
-
Categorize and organize the resources
-
Share the resource collection with fellow students and professionals
Industry Expert Panel Discussion
Show steps
Broaden your industry knowledge and network by connecting with professionals in the field of industrial fermentation.
Show steps
-
Attend a panel discussion with industry experts
-
Engage in Q&A and networking sessions
11 other activities
Expand to see all activities and additional details
Show all 14 activities
Develop a Presentation on Fermentation Process
Show steps
Enhances understanding of the concepts and applications of industrial fermentation through visual and oral presentation.
Show steps
-
Identify the key concepts and principles of industrial fermentation
-
Gather information and data from various sources
-
Create visual aids, such as charts, graphs, and diagrams
-
Develop a logical flow and structure for the presentation
-
Practice delivering the presentation and receive feedback
Solve Fermentation Process Problems
Show steps
Strengthens problem-solving skills and reinforces the application of fermentation principles.
Show steps
-
Review fundamental concepts and equations
-
Practice solving problems related to mass and energy balances
-
Analyze case studies and develop solutions for fermentation process optimization
Fermentation Calculations Workshop
Show steps
Sharpen your mathematical skills and deepen your understanding of fermentation processes through guided calculations.
Show steps
-
Solve mass and energy balance problems
-
Calculate specific growth rates and substrate utilization
-
Apply kinetic models to industrial fermentation
Design a Pilot-Scale Fermentation System
Show steps
Embark on a hands-on project to solidify your understanding of fermentation process design and operation.
Show steps
-
Identify project scope and objectives
-
Research and select appropriate fermentation technology
-
Design and optimize fermentation parameters
-
Develop and implement process control strategies
Design a Bioreactor for Fermentation
Show steps
Applies knowledge of fermentation principles and bioreactor design to create a functional system for industrial production.
Show steps
-
Determine the specifications and requirements for the bioreactor
-
Select the appropriate bioreactor type and configuration
-
Design the bioreactor vessel, including dimensions, materials, and instrumentation
-
Develop a control strategy for the bioreactor
-
Create a detailed engineering drawing of the bioreactor
Learn Bioreactor Modeling
Show steps
Provides a comprehensive understanding of bioreactor modeling and simulation techniques.
Show steps
-
Explore different bioreactor models and their applications
-
Learn about numerical simulation methods and software
-
Develop and validate a bioreactor model for a specific fermentation process
Fermentation Process Optimization Report
Show steps
Enhance your analytical skills by evaluating and proposing improvements to an existing fermentation process.
Browse courses on
Process Optimization
Show steps
-
Analyze process data to identify areas for improvement
-
Develop and evaluate optimization strategies
-
Prepare a comprehensive report on findings and recommendations
Scale Up Fermentation
Show steps
Provides hands-on experience in designing and optimizing a fermentation process for large-scale production.
Show steps
-
Select a fermentation product and develop a process flow diagram
-
Determine the mass and energy balances for the process
-
Design the fermentation reactor and downstream processing unit
-
Simulate the fermentation process using software
-
Identify potential scale-up issues and develop mitigation strategies
Attend a Fermentation Industry Conference
Show steps
Connects with industry professionals and learns about the latest advancements in fermentation technology.
Show steps
-
Research and identify relevant conferences
-
Attend the conference and actively participate in sessions
-
Network with industry experts and potential employers
Metabolic Flux Analysis Simulation
Show steps
Enhance your research capabilities by learning and applying techniques for metabolic flux analysis in industrial fermentation.
Show steps
-
Understand the principles of metabolic flux analysis
-
Use software tools for flux balance analysis
-
Simulate and analyze metabolic pathways
Mentor Junior Students in Fermentation
Show steps
Reinforces knowledge and develops leadership skills by guiding and supporting junior students in their understanding of fermentation.
Show steps
-
Identify opportunities to mentor junior students
-
Provide guidance and support on fermentation concepts and projects
-
Share experiences and insights to foster their learning
Review basic cell and microbiology topics
Show steps
Ensure that your understanding of basic cell and microbiology topics is sound to prepare for more advanced concepts covered in this course.
Show steps
Show steps
Show steps
- Review cell structure and function
- Review microbial growth and metabolism
Compile a Fermentation Resource Collection
Show steps
Gathers and organizes valuable resources to support further learning and exploration of fermentation processes.
Show steps
Show steps
Show steps
- Search for and collect articles, books, videos, and online resources
- Categorize and organize the resources
- Share the resource collection with fellow students and professionals
Industry Expert Panel Discussion
Show steps
Broaden your industry knowledge and network by connecting with professionals in the field of industrial fermentation.
Show steps
Show steps
Show steps
- Attend a panel discussion with industry experts
- Engage in Q&A and networking sessions
11 other activities
Expand to see all activities and additional details
Show all 14 activities
Develop a Presentation on Fermentation Process
Show steps
Enhances understanding of the concepts and applications of industrial fermentation through visual and oral presentation.
Show steps
Show steps
Show steps
- Identify the key concepts and principles of industrial fermentation
- Gather information and data from various sources
- Create visual aids, such as charts, graphs, and diagrams
- Develop a logical flow and structure for the presentation
- Practice delivering the presentation and receive feedback
Solve Fermentation Process Problems
Show steps
Strengthens problem-solving skills and reinforces the application of fermentation principles.
Show steps
Show steps
Show steps
- Review fundamental concepts and equations
- Practice solving problems related to mass and energy balances
- Analyze case studies and develop solutions for fermentation process optimization
Fermentation Calculations Workshop
Show steps
Sharpen your mathematical skills and deepen your understanding of fermentation processes through guided calculations.
Show steps
Show steps
Show steps
- Solve mass and energy balance problems
- Calculate specific growth rates and substrate utilization
- Apply kinetic models to industrial fermentation
Design a Pilot-Scale Fermentation System
Show steps
Embark on a hands-on project to solidify your understanding of fermentation process design and operation.
Show steps
Show steps
Show steps
- Identify project scope and objectives
- Research and select appropriate fermentation technology
- Design and optimize fermentation parameters
- Develop and implement process control strategies
Design a Bioreactor for Fermentation
Show steps
Applies knowledge of fermentation principles and bioreactor design to create a functional system for industrial production.
Show steps
Show steps
Show steps
- Determine the specifications and requirements for the bioreactor
- Select the appropriate bioreactor type and configuration
- Design the bioreactor vessel, including dimensions, materials, and instrumentation
- Develop a control strategy for the bioreactor
- Create a detailed engineering drawing of the bioreactor
Learn Bioreactor Modeling
Show steps
Provides a comprehensive understanding of bioreactor modeling and simulation techniques.
Show steps
Show steps
Show steps
- Explore different bioreactor models and their applications
- Learn about numerical simulation methods and software
- Develop and validate a bioreactor model for a specific fermentation process
Fermentation Process Optimization Report
Show steps
Enhance your analytical skills by evaluating and proposing improvements to an existing fermentation process.
Browse courses on
Process Optimization
Show steps
Show steps
Show steps
- Analyze process data to identify areas for improvement
- Develop and evaluate optimization strategies
- Prepare a comprehensive report on findings and recommendations
Scale Up Fermentation
Show steps
Provides hands-on experience in designing and optimizing a fermentation process for large-scale production.
Show steps
Show steps
Show steps
- Select a fermentation product and develop a process flow diagram
- Determine the mass and energy balances for the process
- Design the fermentation reactor and downstream processing unit
- Simulate the fermentation process using software
- Identify potential scale-up issues and develop mitigation strategies
Attend a Fermentation Industry Conference
Show steps
Connects with industry professionals and learns about the latest advancements in fermentation technology.
Show steps
Show steps
Show steps
- Research and identify relevant conferences
- Attend the conference and actively participate in sessions
- Network with industry experts and potential employers
Metabolic Flux Analysis Simulation
Show steps
Enhance your research capabilities by learning and applying techniques for metabolic flux analysis in industrial fermentation.
Show steps
Show steps
Show steps
- Understand the principles of metabolic flux analysis
- Use software tools for flux balance analysis
- Simulate and analyze metabolic pathways
Mentor Junior Students in Fermentation
Show steps
Reinforces knowledge and develops leadership skills by guiding and supporting junior students in their understanding of fermentation.
Show steps
Show steps
Show steps
- Identify opportunities to mentor junior students
- Provide guidance and support on fermentation concepts and projects
- Share experiences and insights to foster their learning
Career center
Learners who complete Industrial Fermentation will develop knowledge and skills
that may be useful to these careers:
Biotechnology Research Scientist
Biotechnology Research Scientist
A Biotechnology Research Scientist conducts research to develop new and improved fermentation processes. This course would provide you with the knowledge and skills needed to be successful in this role. You would learn about the essential process inputs and outputs, how to design and optimize fermentation processes, and how to scale-up processes from the lab to the factory. This course would also help you to develop the problem-solving and critical thinking skills that are essential for success in this field.
Bioprocess Engineer
Bioprocess Engineer
A Bioprocess Engineer designs, develops, and optimizes biological processes for the production of food, beverages, pharmaceuticals, and other products. This course would provide you with the knowledge and skills needed to be successful in this role. You would learn about the essential process inputs and outputs, how to design and optimize fermentation processes, and how to scale-up processes from the lab to the factory. This course would also help you to develop the problem-solving and critical thinking skills that are essential for success in this field.
Fermentation Scientist
Fermentation Scientist
A Fermentation Scientist is responsible for designing, developing, and optimizing industrial fermentation processes. Industrial fermentation is used to produce a variety of products, including food, beverages, pharmaceuticals, and fuels. This course would provide you with the knowledge and skills needed to be successful in this role. You would learn about the essential process inputs and outputs, how to design and optimize fermentation processes, and how to scale-up processes from the lab to the factory. This course would also help you to develop the problem-solving and critical thinking skills that are essential for success in this field.
Chemical Engineer
Chemical Engineer
A Chemical Engineer designs, develops, and optimizes chemical processes for the production of a variety of products, including food, beverages, pharmaceuticals, and fuels. This course would provide you with the knowledge and skills needed to be successful in this role. You would learn about the essential process inputs and outputs, how to design and optimize fermentation processes, and how to scale-up processes from the lab to the factory. This course would also help you to develop the problem-solving and critical thinking skills that are essential for success in this field.
Environmental Engineer
Environmental Engineer
An Environmental Engineer designs, develops, and optimizes processes to protect the environment. This course would provide you with the knowledge and skills needed to be successful in this role. You would learn about the essential process inputs and outputs, how to design and optimize fermentation processes, and how to scale-up processes from the lab to the factory. This course would also help you to develop the problem-solving and critical thinking skills that are essential for success in this field.
Microbiologist
Microbiologist
A Microbiologist studies microorganisms, such as bacteria, fungi, and viruses. This course would provide you with the knowledge and skills needed to be successful in this role. You would learn about the essential process inputs and outputs, how to design and optimize fermentation processes, and how to scale-up processes from the lab to the factory. This course would also help you to develop the problem-solving and critical thinking skills that are essential for success in this field.
Food Scientist
Food Scientist
A Food Scientist develops new and improved food products. This course would provide you with the knowledge and skills needed to be successful in this role. You would learn about the essential process inputs and outputs, how to design and optimize fermentation processes, and how to scale-up processes from the lab to the factory. This course would also help you to develop the problem-solving and critical thinking skills that are essential for success in this field.
Pharmaceutical Scientist
Pharmaceutical Scientist
A Pharmaceutical Scientist develops new and improved pharmaceutical products. This course would provide you with the knowledge and skills needed to be successful in this role. You would learn about the essential process inputs and outputs, how to design and optimize fermentation processes, and how to scale-up processes from the lab to the factory. This course would also help you to develop the problem-solving and critical thinking skills that are essential for success in this field.
Quality Control Manager
Quality Control Manager
A Quality Control Manager ensures that products meet quality standards. This course would provide you with the knowledge and skills needed to be successful in this role. You would learn about the essential process inputs and outputs, how to design and optimize fermentation processes, and how to scale-up processes from the lab to the factory. This course would also help you to develop the problem-solving and critical thinking skills that are essential for success in this field.
Sales Engineer
Sales Engineer
A Sales Engineer sells products and services to customers. This course would provide you with the knowledge and skills needed to be successful in this role. You would learn about the essential process inputs and outputs, how to design and optimize fermentation processes, and how to scale-up processes from the lab to the factory. This course would also help you to develop the problem-solving and critical thinking skills that are essential for success in this field.
Research and Development Manager
Research and Development Manager
A Research and Development Manager leads research and development projects. This course would provide you with the knowledge and skills needed to be successful in this role. You would learn about the essential process inputs and outputs, how to design and optimize fermentation processes, and how to scale-up processes from the lab to the factory. This course would also help you to develop the problem-solving and critical thinking skills that are essential for success in this field.
Business Analyst
Business Analyst
A Business Analyst analyzes business needs and develops solutions. This course would provide you with the knowledge and skills needed to be successful in this role. You would learn about the essential process inputs and outputs, how to design and optimize fermentation processes, and how to scale-up processes from the lab to the factory. This course would also help you to develop the problem-solving and critical thinking skills that are essential for success in this field.
Project Manager
Project Manager
A Project Manager plans, organizes, and executes projects. This course would provide you with the knowledge and skills needed to be successful in this role. You would learn about the essential process inputs and outputs, how to design and optimize fermentation processes, and how to scale-up processes from the lab to the factory. This course would also help you to develop the problem-solving and critical thinking skills that are essential for success in this field.
Technical Writer
Technical Writer
A Technical Writer writes technical documentation, such as manuals, reports, and proposals. This course would provide you with the knowledge and skills needed to be successful in this role. You would learn about the essential process inputs and outputs, how to design and optimize fermentation processes, and how to scale-up processes from the lab to the factory. This course would also help you to develop the problem-solving and critical thinking skills that are essential for success in this field.
Consultant
Consultant
A Consultant provides advice and guidance to organizations. This course would provide you with the knowledge and skills needed to be successful in this role. You would learn about the essential process inputs and outputs, how to design and optimize fermentation processes, and how to scale-up processes from the lab to the factory. This course would also help you to develop the problem-solving and critical thinking skills that are essential for success in this field.
For more career information including salaries, visit:
OpenCourser.com/course/oqa1x5/industrial
Reading list
We've selected five books
that we think will supplement your
learning. Use these to
develop background knowledge, enrich your coursework, and gain a
deeper understanding of the topics covered in
Industrial Fermentation.
Provides a comprehensive overview of bioprocess engineering principles, focusing on the areas of kinetics, transport phenomena, and scale-up.
Covers the principles and applications of metabolic engineering, which is essential for the design and optimization of industrial fermentation processes.
This textbook provides basic knowledge for biochemical engineers, covering concepts such as enzyme kinetics, fermentation kinetics, microbial growth, and the design of bioreactors and bioprocesses.
This textbook provides a comprehensive overview of bioprocess engineering principles, with a focus on industrial applications. It covers a wide range of topics, including bioreactor design, fermentation processes, and product recovery.
Focuses on the engineering principles of bioprocesses, including microbial metabolism, enzyme kinetics, transport phenomena, and bioreactor design.
For more information about how these books relate to this course, visit:
OpenCourser.com/course/oqa1x5/industrial
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Effort
6 to 8 hours per week for 6 weeks
Level
Introductory
Via
edX
Institution
Delft University of Technology
Instructors
Henk Noorman
Adrie Straathof
Cees Haringa
John Posada Duque
Ludovic Jourdin
Patricia Osseweijer
Wouter van Winden
Session
January 16, 2024
- July 16, 2024
Language
English
Transcript
English
Good to know
Provides foundational knowledge of industrial fermentation processes, making it suitable for beginners seeking an introduction to the field
The course is designed for individuals with a science or engineering background, ensuring relevance to their existing knowledge and skills
Taught by experienced course leaders with expertise in industrial fermentation, ensuring high-quality instruction and practical insights
Emphasizes the design and optimization of industrial fermentation processes, catering to those interested in developing these skills
Provides a comprehensive overview of the field, covering essential aspects such as feedstocks, products, and process design
Equips learners with the knowledge and tools to evaluate and improve industrial fermentation processes, addressing a practical industry need
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