抗菌药与超级细菌－－天使与魔鬼的博弈 from Coursera

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开课致辞

你是否知道，在没有抗菌药的时代，人们可能因为一次普通的感染而丧命？你是否以为，在有着众多抗菌药的今天，面对细菌感染我们大可高枕无忧？你听到了吗？战争的号角已经吹响！超级细菌魔鬼般汹汹来袭，它在宣战！天使般庇护人类的抗菌药已岌岌可危！天使和魔鬼间的殊死搏战已是剑拔弩张！我是复旦大学药学院汤文璐，医药学者和师者的双重使命促使我开设了这门MOOC，为人类打赢这场博弈克尽一份绵薄之力：敲响超级细菌肆虐的警钟，传播实用易懂的抗菌药知识，提高合理使用抗菌药的意识，教育民众投入延缓耐药菌产生的实际行动。这场天使和魔鬼的博弈，战况的介绍按MOOC特点分为7个专题，每个专题介绍4个知识点；按照传统课程的说法，就是整个课程有7章28节的内容。来吧！让我们一起走进这门MOOC——《抗菌药与超级细菌 — 天使与魔鬼的博弈》，找到遏制抗菌药滥用与反击细菌耐药的答案。当你们每一位学习者都成了抵御细菌耐药的生力军，我们终将赢得这场菌药博弈。

WEEK1：第一章超级细菌的肆虐

激烈的博弈打响了！正邪较量，知己知彼方能百战不殆。首先就让我们揭开魔鬼的面纱，看清超级细菌的真面目，这就是第一章——超级细菌的肆虐。本章分为四个小节，第一节领教魔鬼的威力；第二节摸清细菌的家底；第三节剖析细菌耐药的原因；第四节洞悉除魔的方略。超级细菌肆虐，人类正被逼向后抗生素时代的险境。不战则亡。同学们，让我们应战吧：迎击魔鬼拯救人类！

WEEK2：第二章抗菌药的发现历史

曾经，抗菌药天使般拯救人类脱离感染的困境；如今，抗菌药却成了魔鬼的温床！要说清抗菌药的是是非非，还得从源头说起。让我们在历史长河里漫游，用一个个人文故事串起抗菌药诞生的科学之旅，这就是第二章——抗菌药的发现历史。本章分为四个小节，第一节追溯抗菌药的前身——迎击病原；第二节揭幕抗菌药的里程碑——百浪多息；第三节发射抗菌药的原子弹——青霉素；第四节苦寻白色瘟疫的克星——链霉素。每一种熠熠生辉的抗菌药如天使降临，曾挽救了病菌感染中痛苦挣扎的人类。这段历史值得铭记，更呼唤我们每个人担负起护佑天使的重任。

WEEK3：第三章抗菌药的分类与机制

天使降临，人类有了遏制魔鬼的武器；但超级细菌横行，抗菌药威力每况愈下。菌药鏖战之际，我们不能打无准备之仗，必须对抗菌药这一利器有全面透彻的了解和把握，这就是第三章——抗菌药的分类与机制。本章分为四个小节，第一节概览抗菌药的法宝；第二节了解攻破细菌铠甲和防护衣的抗菌药；第三节认识剥夺细菌生命基础的抗菌药；第四节知晓阻断细菌繁殖根源的抗菌药。即便你是非医药专业的普通人，掌握疗效秘笈成为了抗菌药作用百事通，不仅可在日常生活中受益匪浅，更可在这场菌药博弈中助天使一臂之力。

WEEK4：第四章抗菌药的不良反应

武器，既可杀敌也可自伤；抗菌药，就像一把双刃剑，给人类带来极大的益处也造成意想不到的伤害。掌握了抗菌药疗效的一面，同样需要了解其存在安全隐患的另一面，这就是第四章——抗菌药的不良反应。本章分为四个小节，第一节解读“是药三分毒”、洞悉药物不良反应；第二节了解抗菌药常见的不良反应；第三节知晓抗菌药特殊的不良反应；第四节把握抗菌药不良反应的防治措施。具备抗菌药物不良反应的知识，我们既能高悬达摩斯之剑对其安全隐患常保警惕之心，以免伤及自身；也能果断出招智慧用药，尽显抗菌威力，用好抗菌药这把双刃剑。

WEEK5：第五章抗菌药的滥用

抗菌药如天使拯救了人类，人类的肆意妄为却深深地伤害了这位天使。自吞苦果，人类集体成了耐药一族，当真正的恶魔——超级细菌来袭时，已无药可医！这就是第五章——抗菌药的滥用。本章分为四个小节，第一节概览抗菌药从“原子弹”沦落至望“菌”兴叹的滥用状况；第二节挖掘抗菌药滥用的深层次原因；第三节展现抗菌药滥用的骇人后果；第四节揭示抗菌药滥用的防控宝典。正是抗菌药的滥用催生了超级细菌，恰似天使孕育了魔鬼。痛定思痛，让我们积极行动起来，人人智用、善用抗菌药，呵护天使、停止滥用、斩断魔鬼的温床。

WEEK6：第六章抗菌药的使用误区

儿时的记忆是否似曾相识：一有头疼脑热，焦急的妈妈就像搬来救星般递上了抗菌药……然而，抗菌药并不是“万能药”，不同人群也有不同的用药方法和用药剂量，不能千人一药。特别的抗菌药，给特别的“你”，这就是第六章——抗菌药的使用误区。本章分为四个小节，第一节切忌盲目跟风，直击日常生活中抗菌药的八大使用误区；第二节不可爸爸吃啥我吃啥，剖析儿童抗菌药的使用误区；第三节其实母子相连，提醒怀孕和哺乳期的妈妈抗菌药的合理使用；第四节须知特殊人群特殊对待，警示年老和肝、肾病者抗菌药的合理使用。人类因蒙昧无知而误用错用抗菌药，致使天使折翼魔鬼逞凶。让我们迷途知返，用知识武装自己、合理使用抗菌药，细心呵护人类健康的守护天使，不给魔鬼可乘之机。

WEEK7：第七章抗菌药的监管

“抵御耐药性——今天不采取行动，明天就无药可用！”2011年世界卫生日的主题警示着：耐药菌横行魔鬼当道、抗菌药告急天使式微，战事已到了生死存亡的危急关头。起来，不愿被魔鬼蹂躏的人们，让我们站在全球的战略高度既严防死守更主动出击，誓要打赢这场菌药之战！这就是最后的第七章——抗菌药的监管。本章分为四个小节，第一节聚焦WHO如何协调各国联动亮剑，遏制耐药菌的嚣张气焰；第二节且看“买抗生素比买枪还难”的美国如何斩妖除魔；第三节一睹“连动物使用抗菌药也受管制”的欧盟如何围追堵截；第四节见证“监管之路曲折但毅然前行”的中国如何知难而进。天使与魔鬼的激战已呈白热化，如何应对菌药博弈已是全人类的命题。要完胜这场战争，你、我、他，我们每个人都要积极应战！虽任重道远，但我们众志成城。

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Know what's good

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为普通医学专业者和普通民众而设，讲解深入浅出，通俗易懂。

课程的七大模块，覆盖了抗菌药与超级细菌博弈的全过程。

涵盖了抗菌药和超级细菌的知识，并以戏剧化的教学情境剧呈现，让知识更加生动有趣，有助于学生深入理解和记忆。

帮助学生了解抗菌药和超级细菌之间的关系，以及如何合理使用抗菌药，从而预防超级细菌的产生和蔓延。

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Informative and accurate course

This course provides a detailed and accurate overview of the topic. The instructors present the material in a clear and engaging manner, making it easy to understand even for those with no prior knowledge of the subject. Highly recommended!

Activities

Be better prepared before your course. Deepen your understanding during and after it. Supplement your coursework and achieve mastery of the topics covered in 抗菌药与超级细菌－－天使与魔鬼的博弈 with these activities:

Review 1: Antibacterial drugs and their mechanism

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Revisiting the basic concepts of antibacterial drugs and their mechanisms of action will allow you to connect with the foundational knowledge on this subject, thereby enabling you to better grasp the complexities of the course content.

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Go through your notes or textbooks from previous courses related to antibacterial drugs.
Focus on the mechanisms of action of different classes of antibacterial drugs.
Make a summary of the key points.

Practice 2: Classification and mechanism of antibacterial drugs

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Engaging in practice drills on the classification and mechanisms of antibacterial drugs will provide valuable reinforcement, enhancing your understanding and retention of these core concepts.

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Solve practice problems that involve classifying antibacterial drugs based on their mechanisms of action.
Analyze case studies to determine the appropriate antibacterial drugs for specific infections.
Create a table or diagram summarizing the different classes of antibacterial drugs and their mechanisms of action.

Create 3: Create a presentation on the history of antibacterial drugs

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By creating a presentation on the history of antibacterial drugs, you will reinforce your understanding of the evolution of these drugs and their impact on public health.

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Research the major milestones in the development of antibacterial drugs.
Organize your findings into a logical flow of information.
Create visual aids such as slides or posters to illustrate your presentation.
Practice delivering your presentation to an audience.

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Career center

Learners who complete 抗菌药与超级细菌－－天使与魔鬼的博弈 will develop knowledge and skills that may be useful to these careers:

Infectious Disease Physician

Infectious Disease Physicians play a key role in combatting the threat of superbugs. They are responsible for diagnosing and treating infections caused by bacteria, viruses, fungi, and parasites. The course on Antimicrobial Drugs and Superbugs provides a comprehensive overview of the history, classification, mechanisms, and adverse effects of antimicrobial drugs. This knowledge is essential for Infectious Disease Physicians to make informed decisions about the appropriate use of antibiotics and other antimicrobial agents.

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Clinical Microbiologist

Clinical Microbiologists are responsible for identifying and characterizing microorganisms that cause infection. They also develop and implement antimicrobial susceptibility testing to determine the effectiveness of different antibiotics against specific bacteria. The course on Antimicrobial Drugs and Superbugs provides a deep understanding of the mechanisms of antimicrobial resistance and the factors that contribute to the emergence of superbugs. This knowledge is essential for Clinical Microbiologists to stay abreast of the latest developments in the field and to develop effective strategies to combat antimicrobial resistance.

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Pharmacist

Pharmacists play a vital role in ensuring the safe and effective use of antimicrobial drugs. They are responsible for dispensing antibiotics and other antimicrobial agents, providing patient counseling, and monitoring for adverse effects. The course on Antimicrobial Drugs and Superbugs provides Pharmacists with a comprehensive understanding of the different types of antimicrobial drugs, their mechanisms of action, and their potential adverse effects. This knowledge is essential for Pharmacists to provide optimal patient care and to help prevent the development of antimicrobial resistance.

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Epidemiologist

Epidemiologists investigate the causes and patterns of disease outbreaks, including those caused by superbugs. They work to identify risk factors for infection and develop strategies to prevent and control the spread of disease. The course on Antimicrobial Drugs and Superbugs provides Epidemiologists with a solid understanding of the epidemiology of antimicrobial resistance and the factors that contribute to its spread. This knowledge is essential for Epidemiologists to develop effective public health interventions to combat antimicrobial resistance.

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Public Health Advocate

Public Health Advocates work to promote public health and prevent disease. They develop and implement educational campaigns, advocate for policies that protect public health, and work with communities to address health disparities. The course on Antimicrobial Drugs and Superbugs provides Public Health Advocates with a comprehensive understanding of the threat posed by superbugs and the importance of antimicrobial stewardship. This knowledge is essential for Public Health Advocates to effectively advocate for policies and programs that protect public health and prevent the spread of antimicrobial resistance.

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Science Writer

Science Writers communicate complex scientific information to the public. They write articles, blog posts, and other content that explains the latest scientific discoveries and their implications for society. The course on Antimicrobial Drugs and Superbugs provides Science Writers with a solid understanding of the science behind antimicrobial resistance and the threat it poses to public health. This knowledge is essential for Science Writers to accurately and effectively communicate about this important issue.

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Medical Researcher

Medical Researchers conduct research to improve our understanding of disease and develop new treatments. They may work in a variety of settings, including universities, hospitals, and pharmaceutical companies. The course on Antimicrobial Drugs and Superbugs provides Medical Researchers with a comprehensive overview of the latest research on antimicrobial resistance and the development of new antimicrobial agents. This knowledge is essential for Medical Researchers to stay abreast of the latest developments in the field and to conduct research that will help to combat antimicrobial resistance.

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Policy Analyst

Policy Analysts develop and analyze policies that affect public health. They work for government agencies, non-profit organizations, and think tanks. The course on Antimicrobial Drugs and Superbugs provides Policy Analysts with a solid understanding of the policy issues surrounding antimicrobial resistance. This knowledge is essential for Policy Analysts to develop and advocate for policies that will protect public health and prevent the spread of antimicrobial resistance.

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Regulatory Affairs Specialist

Regulatory Affairs Specialists ensure that drugs and medical devices meet safety and efficacy standards. They work for pharmaceutical companies and government agencies. The course on Antimicrobial Drugs and Superbugs provides Regulatory Affairs Specialists with a comprehensive understanding of the regulatory process for antimicrobial drugs. This knowledge is essential for Regulatory Affairs Specialists to ensure that antimicrobial drugs are safe and effective for patients.

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Healthcare Administrator

Healthcare Administrators manage the day-to-day operations of hospitals, clinics, and other healthcare facilities. They ensure that patients receive quality care and that the facility operates efficiently. The course on Antimicrobial Drugs and Superbugs provides Healthcare Administrators with a solid understanding of the challenges posed by antimicrobial resistance and the importance of antimicrobial stewardship. This knowledge is essential for Healthcare Administrators to make informed decisions about how to prevent and control the spread of antimicrobial resistance in their facilities.

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Infection Control Specialist

Infection Control Specialists develop and implement infection prevention and control programs in healthcare settings. They work to prevent the spread of infections, including those caused by superbugs. The course on Antimicrobial Drugs and Superbugs provides Infection Control Specialists with a comprehensive understanding of the epidemiology of antimicrobial resistance and the principles of infection control. This knowledge is essential for Infection Control Specialists to effectively prevent and control the spread of antimicrobial resistance in healthcare settings.

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Health Educator

Health Educators develop and implement educational programs to promote health and prevent disease. They work in a variety of settings, including schools, community centers, and hospitals. The course on Antimicrobial Drugs and Superbugs provides Health Educators with a solid understanding of the threat posed by antimicrobial resistance and the importance of antimicrobial stewardship. This knowledge is essential for Health Educators to effectively educate the public about antimicrobial resistance and how to prevent its spread.

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Pharmaceutical Sales Representative

Pharmaceutical Sales Representatives sell prescription drugs to doctors, hospitals, and other healthcare providers. They provide information about the drugs' benefits and side effects, and they answer questions about how to use the drugs. The course on Antimicrobial Drugs and Superbugs provides Pharmaceutical Sales Representatives with a comprehensive understanding of the different types of antimicrobial drugs, their mechanisms of action, and their potential adverse effects. This knowledge is essential for Pharmaceutical Sales Representatives to effectively sell antimicrobial drugs and to answer questions from healthcare providers about their use.

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Veterinarian

Veterinarians diagnose and treat diseases in animals. They also work to prevent the spread of disease from animals to humans. The course on Antimicrobial Drugs and Superbugs provides Veterinarians with a solid understanding of the epidemiology of antimicrobial resistance and the importance of antimicrobial stewardship in veterinary medicine. This knowledge is essential for Veterinarians to effectively prevent and control the spread of antimicrobial resistance in animals and to protect public health.

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Food Scientist

Food Scientists develop and test new food products. They also work to ensure that food is safe and nutritious. The course on Antimicrobial Drugs and Superbugs provides Food Scientists with a comprehensive understanding of the use of antimicrobial drugs in food production and the potential for antimicrobial resistance to develop. This knowledge is essential for Food Scientists to develop and test new food products that are safe and free from antimicrobial resistance.

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