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Erland Stevens
In this course about drug discovery case studies, students will read five different Drug Annotations articles. Each article will require approximately two hours to read thoroughly and fully process. Including assessment questions based on the articles, the full course should require no more than 15 hours of effort.
Read more
In this course about drug discovery case studies, students will read five different Drug Annotations articles. Each article will require approximately two hours to read thoroughly and fully process. Including assessment questions based on the articles, the full course should require no more than 15 hours of effort.
Read more
In this course about drug discovery case studies, students will read five different Drug Annotations articles. Each article will require approximately two hours to read thoroughly and fully process. Including assessment questions based on the articles, the full course should require no more than 15 hours of effort.
Students in the course should understand lead selection, lead optimization, pharmacodynamics, drug activity, pharmacokinetics, and preclinical safety. A fundamental understanding of the structure of organic molecules and their functional groups is also required. The course has no structure beyond having a module for each case study article. A handful of 10-15-minute videos with discussions of other Drug Annotation articles are provided for reference. Each module provides a link to the open access article on the Journal of Medicinal Chemistry website.
Students signed up for the Audit Track have access to the links to the case studies and the sample Drug Annotation article videos. Students enrolled through the Verified Track also have access to assessment questions.
Register for this course and see more details by visiting:
OpenCourser.com/course/5d0pcf/literature
What's inside
Learning objectives
- Students will learn about several drug programs in the pharmaceutical industry…
- Azd4831 – a compound that reduces incidence of heart failure
- Mrtx0902 – a compound with anti-tumor activity
- Pritelivir – a compound that treats herpes simplex virus infections
- Reldesemitiv -a compound that treats impaired muscle function
- Sebetralstat – a compound that treats hereditary angioedema
- Students will learn about several drug programs in the pharmaceutical industry…
- Azd4831 – a compound that reduces incidence of heart failure
- Mrtx0902 – a compound with anti-tumor activity
- Pritelivir – a compound that treats herpes simplex virus infections
- Reldesemitiv -a compound that treats impaired muscle function
- Sebetralstat – a compound that treats hereditary angioedema
Syllabus
case study 1: Discovery of AZD4831, a mechanism-based irreversible inhibitor of myeloperoxidase, as a potential treatment for heart failure with preserved ejection fractioncase study 2: Design and discovery of MRTX0902, a potent, selective, brain-penetrant, and orally bioavailable inhibitor of the SOS1:KRAS protein−protein interactioncase study 3: Discovery, chemistry, and preclinical development of pritelivir, a novel treatment option for acyclovir-resistant herpes simplex virus infectionscase study 4: Discovery of reldesemtiv, a fast skeletal muscle troponin activator for the treatment of impaired muscle functioncase study 5: Sebetralstat (KVD900): a potent and selective small molecule plasma kallikrein inhibitor featuring a novel P1 group as a potential oral on-demand treatment for hereditary angioedema
Good to know
Good to know
Know what's good ,
what to watch for , and
possible dealbreakers
Taught by instructors with extensive experience in pharmaceutical drug discovery
Examines real-world drug discovery case studies across a range of therapeutic areas, including heart failure, cancer, herpes simplex virus, muscle function, and hereditary angioedema
Develops core knowledge and skills in drug discovery, including lead selection, lead optimization, pharmacodynamics, drug activity, pharmacokinetics, and preclinical safety
Assessed through short answer questions based on case study readings
Requires a fundamental understanding of organic molecules and their functional groups
Has no formal structure beyond modular case study articles
Save this course
Save Literature Case Studies in Drug Discovery to your list so you can find it easily later:
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Activities
Be better prepared
before
your course. Deepen your understanding
during
and
after
it. Supplement your coursework and achieve mastery of the topics covered
in Literature Case Studies in Drug Discovery with these
activities:
Seek Industry Guidance
Show steps
Reach out to professionals in the pharmaceutical industry for mentorship and guidance, gaining valuable insights into real-world drug discovery practices and career paths.
Show steps
-
Identify professionals in the pharmaceutical industry who align with your interests
-
Reach out and request mentorship or informational interviews
-
Prepare questions and actively engage in discussions with your mentors
Review Organic Chemistry and Molecular Biology Concepts
Show steps
Refresh your knowledge of organic chemistry and molecular biology principles to strengthen your foundation for understanding drug discovery concepts.
Browse courses on
Organic Chemistry
Show steps
-
Review lecture notes or textbooks on organic chemistry and molecular biology
-
Complete practice problems related to organic chemistry and molecular biology concepts
Review Key Drug Discovery Concepts
Show steps
Revisit essential concepts such as lead selection, lead optimization, pharmacodynamics, drug activity, pharmacokinetics, and preclinical safety to strengthen your foundation for the course.
Show steps
-
Review lecture notes or textbooks on the fundamentals of drug discovery
-
Complete practice problems related to drug discovery concepts
Four other activities
Expand to see all activities and additional details
Show all seven activities
Attend Virtual Discussion Group
Show steps
Participate in online discussion sessions with peers to share insights, ask questions, and collaborate on case studies, fostering a deeper understanding of the course material.
Show steps
-
Join a virtual discussion group related to the course
-
Engage in discussions on case studies, research papers, or course concepts
Practice Drug Annotation Case Studies
Show steps
Engage in practice drills based on case studies similar to those presented in the course to reinforce your understanding and analytical skills.
Show steps
-
Read and analyze provided case study annotations
-
Answer assessment questions related to the case studies
-
Compare your answers with provided solutions
Provide Guidance to Fellow Students
Show steps
Offer mentorship to other students taking the course by answering questions, providing feedback, or leading study sessions, solidifying your understanding and enhancing your communication skills.
Show steps
-
Identify opportunities to provide support to fellow students
-
Answer questions and provide guidance on course material
-
Organize or participate in study sessions
Develop a Drug Discovery Proposal
Show steps
Compose a comprehensive drug discovery proposal that includes a research question, hypothesis, experimental design, and potential impact to solidify your understanding of the drug discovery process.
Browse courses on
Research Proposal
Show steps
-
Define a research question and hypothesis related to drug discovery
-
Design experiments to test the hypothesis
-
Write a proposal outlining the research plan, expected outcomes, and potential impact
Seek Industry Guidance
Show steps
Reach out to professionals in the pharmaceutical industry for mentorship and guidance, gaining valuable insights into real-world drug discovery practices and career paths.
Show steps
Show steps
Show steps
- Identify professionals in the pharmaceutical industry who align with your interests
- Reach out and request mentorship or informational interviews
- Prepare questions and actively engage in discussions with your mentors
Review Organic Chemistry and Molecular Biology Concepts
Show steps
Refresh your knowledge of organic chemistry and molecular biology principles to strengthen your foundation for understanding drug discovery concepts.
Browse courses on
Organic Chemistry
Show steps
Show steps
Show steps
- Review lecture notes or textbooks on organic chemistry and molecular biology
- Complete practice problems related to organic chemistry and molecular biology concepts
Review Key Drug Discovery Concepts
Show steps
Revisit essential concepts such as lead selection, lead optimization, pharmacodynamics, drug activity, pharmacokinetics, and preclinical safety to strengthen your foundation for the course.
Show steps
Show steps
Show steps
- Review lecture notes or textbooks on the fundamentals of drug discovery
- Complete practice problems related to drug discovery concepts
Four other activities
Expand to see all activities and additional details
Show all seven activities
Attend Virtual Discussion Group
Show steps
Participate in online discussion sessions with peers to share insights, ask questions, and collaborate on case studies, fostering a deeper understanding of the course material.
Show steps
Show steps
Show steps
- Join a virtual discussion group related to the course
- Engage in discussions on case studies, research papers, or course concepts
Practice Drug Annotation Case Studies
Show steps
Engage in practice drills based on case studies similar to those presented in the course to reinforce your understanding and analytical skills.
Show steps
Show steps
Show steps
- Read and analyze provided case study annotations
- Answer assessment questions related to the case studies
- Compare your answers with provided solutions
Provide Guidance to Fellow Students
Show steps
Offer mentorship to other students taking the course by answering questions, providing feedback, or leading study sessions, solidifying your understanding and enhancing your communication skills.
Show steps
Show steps
Show steps
- Identify opportunities to provide support to fellow students
- Answer questions and provide guidance on course material
- Organize or participate in study sessions
Develop a Drug Discovery Proposal
Show steps
Compose a comprehensive drug discovery proposal that includes a research question, hypothesis, experimental design, and potential impact to solidify your understanding of the drug discovery process.
Browse courses on
Research Proposal
Show steps
Show steps
Show steps
- Define a research question and hypothesis related to drug discovery
- Design experiments to test the hypothesis
- Write a proposal outlining the research plan, expected outcomes, and potential impact
Career center
Learners who complete Literature Case Studies in Drug Discovery will develop knowledge and skills
that may be useful to these careers:
Medicinal Chemist
Medicinal Chemist
Medicinal Chemists work to design, create, and test new drugs to address a variety of diseases. This course may be useful by providing a deep understanding of the process of drug discovery and case studies of 5 different drugs brought to market.
Biochemist
Biochemist
Biochemists study the chemical processes that occur in living organisms. This course may be useful in helping build a foundation towards the study of biochemistry. The course provides an understanding of the structure of organic molecules and their functional groups, which is essential for understanding biochemistry.
Pharmacist
Pharmacist
Pharmacists play a vital role in the healthcare system, ensuring that medications are used safely and effectively. This course, in conjunction with appropriate coursework in pharmacy, may be useful for understanding the drug discovery process and how drugs are brought to market.
Biostatistician
Biostatistician
Biostatisticians apply statistical methods to data in the life sciences to improve human health. An understanding of drug discovery case studies may be useful, as they can help biostatisticians better understand the application of statistics to drug development.
Clinical Research Associate
Clinical Research Associate
Clinical Research Associates play a critical role in the drug development process, ensuring that clinical trials are conducted safely and ethically. This course may be useful in helping build a foundation for understanding the drug development process and the role of clinical research.
Chemical Engineer
Chemical Engineer
Chemical Engineers design, construct, and operate chemical plants and other industrial processes. This course may be useful in helping build a foundation towards studying chemical engineering. The course provides an understanding of the structure of organic molecules and their functional groups, which is essential for understanding chemical engineering.
Data Scientist
Data Scientist
Data Scientists use data to solve problems and make predictions. This course may be useful in providing a foundation in understanding the application of data science to drug discovery.
Epidemiologist
Epidemiologist
Epidemiologists investigate the causes of disease and other health problems in populations. This course may be useful in providing a foundation in understanding the application of epidemiology to drug discovery.
Health Policy Analyst
Health Policy Analyst
Health Policy Analysts develop and analyze policies that affect the health of populations. This course may be useful in providing a foundation in understanding the application of health policy to drug discovery.
Medical Writer
Medical Writer
Medical Writers create and edit written materials about medical and health-related topics. This course may be useful in providing a foundation in understanding the drug development process and the role of medical writing.
Nurse
Nurse
Nurses provide care to patients in a variety of settings. This course may be useful in providing a foundation in understanding the drug development process and the role of nurses in administering medications.
Patent Attorney
Patent Attorney
Patent Attorneys help clients obtain and protect patents for their inventions. This course may be useful in providing a foundation in understanding the drug development process and the role of patents in protecting intellectual property.
Physician
Physician
Physicians diagnose and treat diseases and injuries. This course may be useful in providing a foundation in understanding the drug development process and the role of physicians in prescribing medications.
Product Manager
Product Manager
Product Managers are responsible for the development, launch, and marketing of products. This course may be useful in providing a foundation in understanding the drug development process and the role of product managers in bringing new drugs to market.
Regulatory Affairs Specialist
Regulatory Affairs Specialist
Regulatory Affairs Specialists ensure that drugs and medical devices meet regulatory requirements. This course may be useful in providing a foundation in understanding the drug development process and the role of regulatory affairs in bringing new drugs to market.
For more career information including salaries, visit:
OpenCourser.com/course/5d0pcf/literature
Reading list
We've selected 13 books
that we think will supplement your
learning. Use these to
develop background knowledge, enrich your coursework, and gain a
deeper understanding of the topics covered in
Literature Case Studies in Drug Discovery.
As a leading pharmacology textbook, this book offers a comprehensive overview of the field, including drug mechanisms of action, pharmacokinetics, and pharmacodynamics. It would serve as an excellent reference for students interested in exploring these topics in greater depth.
Provides a practical guide to the drug discovery process, covering topics such as target identification, lead optimization, and clinical development. It would be a valuable resource for students interested in learning more about the practical aspects of drug discovery.
Provides a detailed discussion of how drugs work at the molecular level, focusing on the relationship between chemical structure and pharmacological activity.
This molecular biology textbook provides a comprehensive overview of the field, including topics such as gene expression, DNA replication, and cell signaling. It would be a valuable resource for students seeking a deeper understanding of the molecular principles underlying drug discovery.
Save
This introductory textbook covers the principles and concepts of medicinal chemistry, making it a valuable resource for students beginning their studies in this field. It could provide foundational knowledge for understanding the drug design and discovery processes discussed in the course case studies.
This standard pharmacology textbook provides a comprehensive overview of the field, including drug mechanisms of action, pharmacokinetics, and pharmacodynamics. It would be a valuable resource for students seeking a deeper understanding of these concepts as they relate to drug discovery.
Save
This biochemistry textbook provides a comprehensive overview of the field, including topics such as protein structure, enzyme kinetics, and metabolism. It would be a valuable resource for students seeking a deeper understanding of the biochemical principles underlying drug discovery.
Save
This biostatistics textbook provides a comprehensive overview of the field, including topics such as probability, statistical inference, and regression analysis. It would be a valuable resource for students seeking a deeper understanding of the statistical principles underlying drug discovery.
Provides an overview of pharmaceutical biotechnology, including topics such as recombinant DNA technology, protein expression, and drug delivery. It would be a valuable resource for students interested in the application of biotechnology in drug discovery and development.
Provides a practical guide to the design and conduct of clinical trials, covering topics such as protocol development, data management, and statistical analysis. It would be a valuable resource for students interested in the application of clinical trials in drug discovery and development.
This textbook provides a comprehensive overview of biotechnology, including topics such as genetic engineering, bioprocess engineering, and industrial biotechnology. It would be a valuable resource for students interested in the application of biotechnology in drug discovery and development.
Concise and clinically focused textbook of pharmacology and physiology for anesthesia.
This handbook provides a comprehensive overview of the drug discovery process, from target identification through clinical development.
For more information about how these books relate to this course, visit:
OpenCourser.com/course/5d0pcf/literature
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Effort
5 to 10 hours per week for 3 weeks
Level
Intermediate
Via
edX
Institution
Davidson College
Instructor
Erland Stevens
Session
May 8, 2024
- April 9, 2025
Language
English
Transcript
English
Good to know
Taught by instructors with extensive experience in pharmaceutical drug discovery
Examines real-world drug discovery case studies across a range of therapeutic areas, including heart failure, cancer, herpes simplex virus, muscle function, and hereditary angioedema
Develops core knowledge and skills in drug discovery, including lead selection, lead optimization, pharmacodynamics, drug activity, pharmacokinetics, and preclinical safety
Assessed through short answer questions based on case study readings
Requires a fundamental understanding of organic molecules and their functional groups
Has no formal structure beyond modular case study articles
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