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Stephen P. Bell, Tania A. Baker, Mary Ellen Wiltrout, Sera Thornton, and Swati Carr

In Part 3 of 7.28x, you’ll explore translation of mRNA to protein, a key part of the central dogma of biology. Do you know how RNA turnover or RNA splicing affects the outcome of translation? Although not official steps in the central dogma, the mechanisms of RNA processing strongly influence gene expression.

Are you ready to go beyond the “what" of scientific information presented in textbooks and explore how scientists deduce the details of these molecular models?

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In Part 3 of 7.28x, you’ll explore translation of mRNA to protein, a key part of the central dogma of biology. Do you know how RNA turnover or RNA splicing affects the outcome of translation? Although not official steps in the central dogma, the mechanisms of RNA processing strongly influence gene expression.

Are you ready to go beyond the “what" of scientific information presented in textbooks and explore how scientists deduce the details of these molecular models?

Take a behind-the-scenes look at modern molecular biology, from the classic experimental events that identified the proteins and elements involved in translation and RNA splicing to cutting-edge assays that apply the power of genome sequencing. Do you feel confident in your ability to design molecular biology experiments and interpret data from them? We've designed the assessments in this course to build your experimental design and data analysis skills.

Let’s explore the limits of our current knowledge about the translation machinery and mechanisms of RNA turnover and splicing. If you are up for the challenge, join us in 7.28.3x Molecular Biology: RNA Processing and Translation.

What's inside

Learning objectives

  • How to compare and contrast translation in bacteria and eukaryotes
  • How to describe several mechanisms of rna turnover and rna splicing
  • How to analyze protein structures to infer functional information
  • How to design the best experiment to test a hypothesis
  • How to interpret data from translation and rna processing experiments

Syllabus

Week 1: Translation I – Overview and Key PlayersWeek 2: Translation II – ElongationWeek 3: Translation III – Initiation and TerminationWeek 4: Translation IV – Regulation of TranslationWeek 5: RNA Splicing I – MechanismsWeek 6: RNA Splicing II – Proofreading and Alternative SplicingWeek 7: RNA Turnover I – Assays and General MechanismsWeek 8: RNA Turnover II – Specific Bacterial and Eukaryotic Mechanisms

Good to know

Know what's good
, what to watch for
, and possible dealbreakers
Explores advanced molecular biology topics, including translation, RNA splicing, and RNA turnover, which are essential for understanding gene expression and regulation
Taught by renowned experts in the field of molecular biology, Mary Ellen Wiltrout, Stephen P. Bell, Tania A. Baker, Sera Thornton, and Swati Carr
Provides a strong theoretical foundation and practical applications in molecular biology, making it suitable for students with a keen interest in the subject
Covers a wide range of topics in molecular biology, offering a comprehensive understanding of gene expression and regulation
Assessments are designed to build experimental design and data analysis skills, which are essential for research and development in molecular biology
Requires a strong background in molecular biology and biochemistry, making it more suitable for advanced learners or those with a specific interest in the field

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Reviews summary

Well-received molecular biology course

Learners say that this is an excellent course and they highly recommend it. They find the professor to be an exceptional presenter and the material to be very well-visualized and explained. The course is challenging, but the effort is well worth it. Students appreciate that the course builds on the previous two courses in the series and provides a deep dive into the complex topic of protein translation.

Activities

Be better prepared before your course. Deepen your understanding during and after it. Supplement your coursework and achieve mastery of the topics covered in Molecular Biology – Part 3: RNA Processing and Translation with these activities:
Translation and RNA Processing Review
Reviewing key concepts in translation and RNA processing will help you prepare for the course and refresh your memory.
Browse courses on Translation
Show steps
  • Re-read your previous notes and textbooks.
  • Complete practice questions or quizzes.
  • Discuss key concepts with peers or the instructor.
Molecular Biology of the Cell
This comprehensive textbook provides a foundation in molecular biology, including in-depth coverage of translation and RNA processing.
Show steps
  • Read assigned chapters and take notes.
  • Complete end-of-chapter exercises.
  • Discuss key concepts with classmates or the instructor.
RNA Turnover Study Group
Participating in a study group will provide you with a supportive environment to discuss and explore concepts related to RNA turnover.
Show steps
  • Find or form a study group with fellow students.
  • Meet regularly to discuss course materials.
  • Work together to solve problems and clarify concepts.
Five other activities
Expand to see all activities and additional details
Show all eight activities
Translation and RNA Processing Practice Problems
Solving practice problems will strengthen your understanding of key concepts and principles related to translation and RNA processing.
Browse courses on Translation
Show steps
  • Review lecture notes and course materials to identify key concepts.
  • Attempt practice problems on your own.
  • Check your answers and identify areas where you need improvement.
Attend Molecular Biology Conference
Attending a molecular biology conference will expose you to cutting-edge research and connect you with experts in the field.
Browse courses on Molecular Biology
Show steps
  • Research and identify relevant conferences.
  • Register and attend the conference.
  • Network with researchers and professionals.
Protein Structure Analysis Tutorial
Following tutorials on protein structure analysis will enhance your ability to analyze and interpret protein structures.
Browse courses on Protein Structure
Show steps
  • Find a reputable tutorial on protein structure analysis.
  • Follow the tutorial steps and complete the exercises.
  • Apply your new skills to analyze actual protein structures.
Experimental Design Workshop
Attending an experimental design workshop will enhance your skills in designing and conducting molecular biology experiments.
Browse courses on Experimental Design
Show steps
  • Research and identify relevant workshops.
  • Register and attend the workshop.
  • Participate actively in discussions and exercises.
  • Apply your new skills to your own research projects.
RNA Splicing Simulation
Creating a simulation of RNA splicing will provide you with a deeper understanding of the mechanisms and processes involved.
Show steps
  • Research and gather information about RNA splicing.
  • Design and develop a simulation model.
  • Test and refine your simulation.
  • Share your simulation with others.

Career center

Learners who complete Molecular Biology – Part 3: RNA Processing and Translation will develop knowledge and skills that may be useful to these careers:
Bioinformatician
Bioinformaticians use computer programming and statistical techniques to analyze large sets of biological data, such as DNA sequences. This course would be helpful for aspiring bioinformaticians because it provides a strong foundation in molecular biology, including RNA processing and translation. This knowledge is essential for understanding the data that bioinformaticians analyze.
Molecular Biologist
Molecular biologists study the structure and function of molecules, including DNA, RNA, and proteins. This course would be helpful for aspiring molecular biologists because it provides a detailed overview of RNA processing and translation. This knowledge is essential for understanding how cells function.
Geneticist
Geneticists study the inheritance of traits from parents to offspring. This course would be helpful for aspiring geneticists because it provides a strong foundation in molecular biology, including RNA processing and translation. This knowledge is essential for understanding how genes are passed down from generation to generation.
Biochemist
Biochemists study the chemical reactions that occur in living organisms. This course would be helpful for aspiring biochemists because it provides a strong foundation in molecular biology, including RNA processing and translation. This knowledge is essential for understanding how cells function.
Cell Biologist
Cell biologists study the structure and function of cells. This course would be helpful for aspiring cell biologists because it provides a strong foundation in molecular biology, including RNA processing and translation. This knowledge is essential for understanding how cells function.
Microbiologist
Microbiologists study microorganisms, such as bacteria and viruses. This course would be helpful for aspiring microbiologists because it provides a strong foundation in molecular biology, including RNA processing and translation. This knowledge is essential for understanding how microorganisms function and how they can cause disease.
Pathologist
Pathologists study the causes and effects of disease. This course would be helpful for aspiring pathologists because it provides a strong foundation in molecular biology, including RNA processing and translation. This knowledge is essential for understanding how diseases develop and how they can be treated.
Pharmacologist
Pharmacologists study the effects of drugs on the body. This course would be helpful for aspiring pharmacologists because it provides a strong foundation in molecular biology, including RNA processing and translation. This knowledge is essential for understanding how drugs work and how they can be used to treat disease.
Toxicologist
Toxicologists study the effects of toxins on the body. This course would be helpful for aspiring toxicologists because it provides a strong foundation in molecular biology, including RNA processing and translation. This knowledge is essential for understanding how toxins work and how they can be prevented from causing harm.
Epidemiologist
Epidemiologists study the distribution and patterns of disease in populations. This course would be useful for aspiring epidemiologists because it provides a strong foundation in molecular biology, including RNA processing and translation. This knowledge is essential for understanding how diseases spread and how they can be prevented.
Science Writer
Science writers communicate complex scientific information to the public. This course would be useful for aspiring science writers because it provides a strong foundation in molecular biology, including RNA processing and translation. This knowledge is essential for understanding the scientific research that they will be writing about.
Science Teacher
Science teachers educate students about science. This course would be useful for aspiring science teachers because it provides a strong foundation in molecular biology, including RNA processing and translation. This knowledge is essential for understanding the science that they will be teaching.
Research Scientist
Research scientists conduct original research in a variety of scientific fields. This course would be useful for aspiring research scientists because it provides a strong foundation in molecular biology, including RNA processing and translation. This knowledge is essential for conducting research in this field.
Laboratory Technician
Laboratory technicians conduct experiments and analyze data under the supervision of a scientist. This course would be useful for aspiring laboratory technicians because it provides a strong foundation in molecular biology, including RNA processing and translation. This knowledge is essential for understanding the experiments that they will be conducting.
Quality Control Analyst
Quality control analysts ensure that products meet safety and quality standards. This course would be useful for aspiring quality control analysts because it provides a strong foundation in molecular biology, including RNA processing and translation. This knowledge is essential for understanding the products that they will be testing.

Reading list

We've selected 17 books that we think will supplement your learning. Use these to develop background knowledge, enrich your coursework, and gain a deeper understanding of the topics covered in Molecular Biology – Part 3: RNA Processing and Translation.
This is the classic textbook in cell and molecular biology. It comprehensive reference that can be used for background or additional reading. It is commonly used as a textbook at academic institutions.
Good overview of gene expression, including RNA processing and translation. It good reference for additional reading.
Good overview of RNA. It is more detailed than the course, but it good reference for additional reading.
Provides a broad overview of gene expression, including chapters on RNA processing and translation.
A practical guide to molecular biology techniques, including methods for studying RNA processing and translation.
Detailed overview of translation. It good reference for additional reading.
Covers computational methods for analyzing RNA-seq data, which can be used to study RNA processing and translation.
Can be a resource for anyone who wants to design their own molecular biology experiments.
A comprehensive overview of translational control, including sections on the regulation of translation initiation, elongation, and termination.
Good overview of molecular biology. It covers RNA processing and translation in a few chapters.
Good overview of biochemistry. It covers RNA processing and translation in a few chapters.

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