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Epigenetic Control of Gene Expression

While the human genome sequence has transformed our understanding of human biology, it isn’t just the sequence of your DNA that matters, but also how you use it! How are some genes activated and others are silenced? How is this controlled? The answer is epigenetics. Epigenetics has been a hot topic for research over the past decade as it has become clear that aberrant epigenetic control contributes to disease (particularly to cancer). Epigenetic alterations are heritable through cell division, and in some instances are able to behave similarly to mutations in terms of their stability. Importantly, unlike genetic mutations, epigenetic modifications are reversible and therefore have the potential to be manipulated therapeutically. It has also become clear in recent years that epigenetic modifications are sensitive to the environment (for example diet), which has sparked a large amount of public debate and research. This course will give an introduction to the fundamentals of epigenetic control. We will examine epigenetic phenomena that are manifestations of epigenetic control in several organisms, with a focus on mammals. We will examine the interplay between epigenetic control and the environment and finally the role of aberrant epigenetic control in disease. All necessary information will be covered in the lectures, and recommended and required readings will be provided. There are no additional required texts for this course. For those interested, additional information can be obtained in the following textbook. Epigenetics. Allis, Jenuwein, Reinberg and Caparros. Cold Spring Harbour Laboratory Press. ISBN-13: 978-0879697242 | Edition: 1

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The University of Melbourne

Rating 4.7 based on 95 ratings
Length 8 weeks
Effort 7 weeks of study, 6-8 hours/week
Starts Jun 3 (next week)
Cost $49
From The University of Melbourne via Coursera
Instructor Dr. Marnie Blewitt
Download Videos On all desktop and mobile devices
Language English
Subjects Science
Tags Life Sciences Medicine And Healthcare Biology Basic Science

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What people are saying

We analyzed reviews for this course to surface learners' thoughts about it

dr. marnie blewitt in 4 reviews

I felt her love to the topic with the words and representation the professor done in this course I wish for her the best and to keep passion about the epigenetics as well as continue to add to our knowledge and teach us more and more An amazing course directed wonderfully by Dr. Marnie Blewitt.

Very nicely prepared and elucidated by Dr. Marnie Blewitt .Many many thanks to Dr. Marnie Blewitt & Coursera team.

Thank you Excellent course and i can say one of the best courses when it comes gene expression and i wanna thank to Dr. Marnie Blewitt I highly recommend this course for anyone who wants to understand what epigenetics is all about, how the discoveries were made, and what are the open questions in the area.I wanted to give a big shout out to Dr. Marnie Blewitt for her great teaching skills.

very well in 4 reviews

Very well structured and explained.

Very well explained.

Nicee Very well done.

very well planned course.

took this course in 3 reviews

I took this course as I was already very interested in genetics and considering doing my undergraduates degree in that rather than medicine or "pure" biology.

I am with computer background but then also took this course and did well!

I took this course because I am interested in epigenetics.

strongly recommend in 3 reviews

I strongly recommend this course, I learned a lot more than I expected to learn.

I'd strongly recommend it to prospective students and academicians.

I strongly recommend this course to biologstudents who did not have the opportunity to go into detail about epigenetics.

very informative in 3 reviews

Very informative.

Very informative!

Very informative, descriptive and useful.

really enjoyed in 3 reviews

Awesome This course was really inspiring and I really enjoyed the part about histone modification, X chromosome inactivation and the influence of an environment on epigenome.

I really enjoyed this course it's really interesting and I learned a lot about epigenetics.

I really liked the professor and the way she explained and really enjoyed the materials she suggested us to read.

I really enjoyed this course, and as an Australian it is so exciting it comes form a domestic university.

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Coursera

&

The University of Melbourne

Rating 4.7 based on 95 ratings
Length 8 weeks
Effort 7 weeks of study, 6-8 hours/week
Starts Jun 3 (next week)
Cost $49
From The University of Melbourne via Coursera
Instructor Dr. Marnie Blewitt
Download Videos On all desktop and mobile devices
Language English
Subjects Science
Tags Life Sciences Medicine And Healthcare Biology Basic Science

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