DNA Decoded from Coursera

What's inside

Syllabus

Cracking the Genetic Code

In this module, we'll explore the molecular structure of DNA. What is DNA? What are the basic building blocks of DNA? Where can you find DNA within a cell? We'll learn about how James Watson and Francis Crick were able to solve the riddle of the molecular structure of DNA by building on the work of other scientists. Their groundbreaking discovery revealed that four nucleobases (adenine, thymine, cytosine, and guanine) combine with sugar and phosphate molecules to form the familiar double helix of DNA. We'll take a look at how the molecular structure of DNA regulates its functions; for example, how the chemical bonds (covalent and noncovalent) between these molecules allow DNA to "unzip" during replication. Then we'll take a look at how you manage to fit over three billion base pairs into each of your cells. (Here's a hint: Histones, nucleosomes, and chromosomes would be great at packing for a trip!)

Getting the Message Across: Transcription, Translation, and Replication

We've all heard DNA described as "the blueprint of life," but what does that actually mean? Each one of the approximately 20,000 genes in our bodies contains the instructions for building a protein. In this module, we'll explain how RNA copies the genetic information contained in our genes and uses this information to assemble amino acids into proteins. Scientists call this concept "Central Dogma": DNA makes RNA and RNA makes protein. We'll also explore how we transmit genetic information from one cell to another -- and what happens when things go wrong. Along the way, we'll learn about techniques (such as polymerase chain reactions and gel electrophoresis) that forensic scientists use in DNA fingerprinting. Join us this week for murder and mayhem in the lab!

Manipulating DNA

In this module, we'll explore the techniques scientists use to manipulate DNA. Genetic engineering has allowed us to increase crop yields, diagnose illnesses, develop vaccines, and manufacture insulin. By carefully selecting a pair of molecular scissors (restriction enzymes), scientists are able to isolate a gene of interest and insert it into plasmid DNA, turning a common bacteria (E. coli) into a molecular copying machine. This week, we'll learn that mutations are genetic errors, but that not all mutations are necessarily bad — in fact, some mutations confer a selective advantage that protects against disease. We'll explain what genetically modified organisms are (and what they are not) and weigh in on the heated debates about the ethics and safety of GMOs in popular media.

DNA and Me

What does your DNA say about you? You may have heard that you share 99% of your genetic material with everyone else on the planet. That's true, but this week we're going to take a look at the less than 1% that makes you unique. We'll kick off by discussing the Human Genome Project, the massive scientific collaboration that mapped out the sequence of all our genetic material. The technologies developed while mapping out the human genome ushered in a new age in DNA research. Now, genome-wide association studies can analyze massive amounts of data, searching for genetic variations that are associated with particular diseases. Pharmacogenomics may help determine which drugs are likely be most effective for you. Genetic genealogy tests (such as Ancestry DNA, 23 and Me, and Family Tree DNA) will allow you to trace random mutations in your DNA that can provide clues to your ethnic heritage. As an added bonus, we'll discuss whether it would be possible to revive extinct species by studying ancient DNA.

Good to know

Know what's good

, what to watch for

, and possible dealbreakers

Provides an accessible introduction to the structure and function of DNA, making it a valuable resource for beginners

Taught by two biochemists from McMaster University, ensuring high-quality content and subject matter expertise

Covers practical techniques used in forensic DNA analysis, providing hands-on learning opportunities

Examines the ethical implications of genetic engineering and GMOs, fostering critical thinking and ethical decision-making

Leverages real-world examples and case studies, making the learning experience more engaging and applicable

Provides a comprehensive overview of the field of DNA science, suitable for diverse audiences with varying knowledge levels

Reviews summary

Dna decoded: <span>engaging</span> insights into our genetic blueprint

learners say DNA Decoded is an informative and entertaining course that delivers key concepts in a fun and accessible way. The course, taught by enthusiastic instructors Felicia Vulcu and Caitlin Mullarkey, covers topics such as DNA structure, genetic engineering, and the history of DNA research. Students appreciate the use of videos, simulations, and interactive activities to illustrate complex scientific concepts. Overall, this course is highly recommended for anyone interested in gaining a deeper understanding of DNA and its implications for our lives.

The course provides a historical perspective on DNA research, highlighting the contributions of key scientists.

"This course really gave me a good understanding of how DNA behaves and builds off itself. "

"Refresher and learned new concepts. Love it!"

"Fascinating illustrationsI love the chemistry between doctors Thanks !!!"

Fun and easy-to-understand lectures keep students engaged throughout the course.

"Very interesting and entertaining."

"Amazing fantastic course really "

"It was fun and easy to learn new things "

Interactive simulations and activities reinforce key concepts and make learning interactive.

"Very nice interactive and good course faculty is also good and excellently made course ."

"very goodi have learned a lot . wish to learn lot of courses like this thanq coursera . "

"It was so much fun! So educational yet so entertaining, the doctors should be on TV. "

Felicia Vulcu and Caitlin Mullarkey are passionate and knowledgeable instructors who make learning about DNA enjoyable.

"All concepts were creatively and efficiently delivered."

"It was an honor and pleasure to me thank you for this amazing beneficial course"

"BEST TEACHING EVER . FUNNY AND FRIENDLY ENVIRONMENT I WILL MISS PROFESSORS"

Some students experienced technical difficulties with the virtual laboratory simulations.

"Some videos and external links doesnt work"

"4 out of 312 reviews mention technical issues"

Activities

Be better prepared before your course. Deepen your understanding during and after it. Supplement your coursework and achieve mastery of the topics covered in DNA Decoded with these activities:

Form a study group with classmates

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Collaborate with peers to discuss course material, share insights, and reinforce learning.

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Identify classmates who are interested in forming a study group
Establish regular meeting times and locations
Review course materials, discuss concepts, and work on problems together
Provide feedback and support to each other

Read 'The Double Helix' by James D. Watson

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Gain historical perspective on the discovery of DNA's structure and the development of molecular biology.

View DNA on Amazon

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Read molecular biology textbook

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Review key biological concepts and prepare for more advanced course material.

Browse courses on Molecular Biology

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Collect any necessary reading materials
Break up reading into manageable chunks
Read and take notes on assigned chapters
Complete any end-of-chapter questions or exercises

Five other activities

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Show all eight activities

Complete Coursera's 'DNA and the Mystery of Life'

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Reinforce course concepts through interactive tutorials and hands-on activities.

Browse courses on Molecular Biology

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Create a Coursera account
Enroll in the 'DNA and the Mystery of Life'
Complete each tutorial in the course

Solve online genetics problems

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Strengthen problem-solving skills and apply course concepts to real-world scenarios.

Browse courses on Genetics

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Find a reputable online genetics problem database
Select problems at various difficulty levels
Work through the problems, checking your answers as you go
Review incorrect answers to identify areas for improvement

Develop a DNA replication infographic

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Enhance understanding of the complex process of DNA replication through visual representation.

Browse courses on DNA Replication

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Gather information on the steps of DNA replication
Design a visually appealing infographic layout
Create clear and concise graphics and text to illustrate the process
Proofread and finalize the infographic

Contribute to open-source genetic databases

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Enhance research skills and contribute to the advancement of genetic knowledge by sharing data and collaborating with others.

Browse courses on Genetics

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Identify reputable open-source genetic databases
Explore the databases and identify areas where you can contribute
Contribute data, annotations, or other relevant information
Collaborate with other contributors to ensure data quality and accuracy

Design a genetic experiment to test a hypothesis

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Apply course concepts to real-world research by designing and conducting your own genetic experiment.

Browse courses on Genetics

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Identify a research question and hypothesis
Design the experiment, including methods and protocols
Obtain necessary materials and resources
Conduct the experiment and collect data
Analyze the data and draw conclusions

Career center

Learners who complete DNA Decoded will develop knowledge and skills that may be useful to these careers:

Genetic Engineer

Genetic Engineers use laboratory techniques to alter the DNA of living organisms, opening up new possibilities for medical treatments, agricultural advancements, and industrial applications. This course, DNA Decoded, provides a comprehensive overview of the structure and function of DNA, as well as the techniques used to manipulate it. With this in-depth knowledge, you will be well-prepared to pursue a career in genetic engineering and contribute to the development of innovative technologies that address real-world challenges.

See salaries and explore the career path for Genetic Engineer

Molecular Biologist

Molecular Biologists study the structure and function of molecules in living organisms, with a focus on DNA and RNA. This course, DNA Decoded, delves into the molecular structure of DNA, the process of transcription and translation, and the techniques used to manipulate DNA. For those who wish to succeed in this field, a thorough understanding of these topics is essential, making this course an invaluable resource.

See salaries and explore the career path for Molecular Biologist

Research Scientist

Research Scientists conduct scientific research to advance our understanding of the world around us. Many research scientists focus on the study of DNA and genetics. This course provides an in-depth exploration of DNA, including its molecular structure, how it replicates, and how it is used to create proteins, providing you with a strong foundation for a career in this field.

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Biochemist

Biochemists study the chemical processes that occur in living organisms. For those who wish to succeed in this field, understanding the structure and function of DNA is essential. This course, DNA Decoded, provides an in-depth exploration of DNA, including its molecular structure, how it replicates, and how it is used to create proteins. With topics that cover everything from the Human Genome Project to genetic engineering, this course could help you build a solid foundation for a career in biochemistry.

See salaries and explore the career path for Biochemist

Epidemiologist

Epidemiologists investigate the causes and patterns of disease in populations, with a focus on identifying risk factors and developing prevention strategies. This course, DNA Decoded, provides an in-depth exploration of DNA, including its molecular structure, how scientists cracked the genetic code, and what our DNA can tell us about ourselves. With a strong understanding of these topics, you will be well-equipped to contribute to the field of epidemiology by studying the genetic basis of disease and developing effective public health interventions.

See salaries and explore the career path for Epidemiologist

Biostatistician

Biostatisticians apply statistical methods to data in the biological sciences to draw meaningful conclusions. This course, DNA Decoded, explores the structure of DNA, how scientists cracked the genetic code, and what our DNA can tell us about ourselves. With this in-depth understanding of DNA and genetics, you will be well-prepared to design and conduct statistical analyses that advance our knowledge in the biological sciences.

See salaries and explore the career path for Biostatistician

Forensic Scientist

Forensic Scientists collect and analyze evidence to help solve crimes. One of the most important tools they use is DNA analysis. This course provides a comprehensive overview of DNA fingerprinting techniques, which can be used to identify suspects and exonerate the innocent. If you are interested in a career in forensic science, this course could give you the knowledge and skills you need to succeed.

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Wildlife Biologist

Wildlife Biologists study the behavior, ecology, and conservation of wild animals. Many wildlife species are threatened by habitat loss, climate change, and other environmental factors, which can have a genetic impact on their populations. This course provides an overview of the basic principles of genetics, as well as information on specific genetic disorders that affect wildlife, equipping you with the knowledge you need to understand and address these threats.

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Genetic Counselor

Genetic Counselors help individuals and families understand and manage their genetic risks. To be successful in this field, it is essential to have a strong understanding of DNA and genetics. This course provides an overview of the basic principles of genetics, as well as information on specific genetic disorders. It also covers ethical issues related to genetic testing and counseling. If you are interested in a career as a genetic counselor, this course could provide you with the foundation you need.

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Science Teacher

Science Teachers educate students about the natural world, including the study of DNA and genetics. This course provides an overview of the basic principles of genetics, as well as information on specific genetic disorders, equipping you with the knowledge you need to effectively teach these concepts to your students.

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Veterinarian

Veterinarians diagnose and treat diseases and injuries in animals. Many animal diseases have a genetic component, so it is important for veterinarians to have a basic understanding of genetics. This course provides an overview of the basic principles of genetics, as well as information on specific genetic disorders that affect animals, providing you with the foundation you need to succeed in this field.

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Medical Doctor

Medical Doctors diagnose and treat diseases and injuries. Many medical conditions have a genetic component, so it is important for doctors to have a basic understanding of genetics. This course provides an overview of the basic principles of genetics, as well as information on specific genetic disorders. If you are interested in a career as a medical doctor, this course could provide you with the foundation you need to understand the genetic basis of disease.

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Registered Nurse

Registered Nurses provide care to patients in a variety of settings. Many medical conditions have a genetic component, so it is important for registered nurses to have a basic understanding of genetics. This course provides an overview of the basic principles of genetics, as well as information on specific genetic disorders. If you are interested in a career as a registered nurse, this course could provide you with the foundation you need to understand the genetic basis of disease.

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Physician Assistant

Physician Assistants provide medical care under the supervision of a physician. Many medical conditions have a genetic component, so it is important for physician assistants to have a basic understanding of genetics. This course provides an overview of the basic principles of genetics, as well as information on specific genetic disorders. If you are interested in a career as a physician assistant, this course could provide you with the foundation you need to understand the genetic basis of disease.

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Pharmacist

Pharmacists dispense medications and provide advice on their use. Many medications have genetic implications, so it is important for pharmacists to have a basic understanding of genetics. This course provides an overview of the basic principles of genetics, as well as information on specific genetic disorders. If you are interested in a career as a pharmacist, this course could provide you with the foundation you need to understand the genetic basis of drug action.

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