What is continuous manufacturing? How does continuous manufacturing improve a company’s productivity and flexibility? What are the advantages of continuous manufacturing? Which technologies exist and how are they controlled? Why is continuous manufacturing, much faster and leads to better quality? These are questions that we will answer in this course.
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What is continuous manufacturing? How does continuous manufacturing improve a company’s productivity and flexibility? What are the advantages of continuous manufacturing? Which technologies exist and how are they controlled? Why is continuous manufacturing, much faster and leads to better quality? These are questions that we will answer in this course.
What is continuous manufacturing? How does continuous manufacturing improve a company’s productivity and flexibility? What are the advantages of continuous manufacturing? Which technologies exist and how are they controlled? Why is continuous manufacturing, much faster and leads to better quality? These are questions that we will answer in this course.
Over the last years, pharmaceutical manufacturing has changed tremendously by implementing new and advanced manufacturing methods. This course will provide the fundamentals of continuous manufacturing, focusing on solid dosage forms. The equipment used to produce such medicines will be introduced. Advanced quality control strategies will be discussed.
Clearly, robust process control can only be maintained if the manufacturing process is monitored in real-time. Thus, this course will explain the fundamentals of online measurement, i.e., Process Analytical Technology (PAT) and innovative concepts, such as Real Time Release Testing (RTRT). After taking this course, you will understand the basic principles of continuous manufacturing, the associated technology and you will be able to understand process development and process control for such processes.
What you'll learn
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You will learn why continuous manufacturing can give you huge advantages when establishing a production process.
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We will discuss the different paradigms of batch and continuous manufacturing.
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The basic flow concepts in continuous production will be explained and demonstrated with examples.
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The residence time and its distribution are essential concepts in continuous production; they will be explained in detail. Also, we will introduce methods how to measure the residence time distribution.
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We will discuss the three main continuous manufacturing routes; direct-compaction, dry-granulation, and wet-granulation.
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Material and process properties influence each other. This interaction will be discussed by considering critical material attributes and critical process parameters.
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You will learn to understand the fundamentals of a control strategy based on different process control options.
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Quality monitoring and quality control aspects in manufacturing and process design will be explained.
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Activities
Principles of continuous manufacturing
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Familiarize yourself with the basic principles and advantages of continuous manufacturing to build a foundation for the upcoming course.
Browse courses on
Continuous Manufacturing
Show steps
-
Review the course syllabus and introductory materials.
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Read a summary article on Wikipedia or a peer-reviewed journal about continuous manufacturing.
Solving differential equations for modeling continuous manufacturing
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Practice solving differential equations to model and analyze the dynamics of continuous manufacturing processes.
Browse courses on
Mathematical Modeling
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-
Review the fundamentals of differential equations and their applications in modeling.
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Solve a series of practice problems involving differential equations for continuous manufacturing processes.
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Apply the techniques to analyze the stability and performance of different process configurations.
Online discussion group on continuous manufacturing
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Join an online discussion group to connect with peers, ask questions, and share knowledge related to continuous manufacturing.
Show steps
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Identify an online forum or platform for connecting with other learners in the field.
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Introduce yourself and share your interests in continuous manufacturing.
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Participate in discussions, ask questions, and share resources.
Three other activities
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Show all six activities
Simulating continuous tablet production using MATLAB or Python
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Develop a simulation model in MATLAB or Python to simulate the continuous production of tablets, including blending, granulation, compression, and coating processes.
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MATLAB
Show steps
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Choose a software platform for simulation (MATLAB or Python).
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Gather data and parameters for the different process units.
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Develop and implement the simulation model.
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Validate the model by comparing simulation results with experimental data.
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Use the model to optimize the continuous production process.
Interactive simulation of a continuous manufacturing process
Show steps
Create an interactive simulation that allows users to visualize and understand the key steps involved in continuous manufacturing.
Browse courses on
Interactive Simulations
Show steps
-
Choose a software platform for creating interactive simulations (e.g., Unity or Processing).
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Design and implement a graphical user interface for the simulation.
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Develop the simulation logic to model the continuous manufacturing process.
Proposal for implementing continuous manufacturing in a pharmaceutical plant
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Develop a comprehensive proposal outlining the benefits and feasibility of implementing continuous manufacturing in a pharmaceutical plant setting.
Browse courses on
Implementation Planning
Show steps
-
Analyze the current manufacturing process and identify opportunities for improvement.
-
Research and gather data on the benefits and challenges of continuous manufacturing.
-
Develop a detailed implementation plan, including timelines and resource requirements.
Principles of continuous manufacturing
Show steps
Familiarize yourself with the basic principles and advantages of continuous manufacturing to build a foundation for the upcoming course.
Browse courses on
Continuous Manufacturing
Show steps
- Review the course syllabus and introductory materials.
- Read a summary article on Wikipedia or a peer-reviewed journal about continuous manufacturing.
Solving differential equations for modeling continuous manufacturing
Show steps
Practice solving differential equations to model and analyze the dynamics of continuous manufacturing processes.
Browse courses on
Mathematical Modeling
Show steps
- Review the fundamentals of differential equations and their applications in modeling.
- Solve a series of practice problems involving differential equations for continuous manufacturing processes.
- Apply the techniques to analyze the stability and performance of different process configurations.
Online discussion group on continuous manufacturing
Show steps
Join an online discussion group to connect with peers, ask questions, and share knowledge related to continuous manufacturing.
Show steps
- Identify an online forum or platform for connecting with other learners in the field.
- Introduce yourself and share your interests in continuous manufacturing.
- Participate in discussions, ask questions, and share resources.
Simulating continuous tablet production using MATLAB or Python
Show steps
Develop a simulation model in MATLAB or Python to simulate the continuous production of tablets, including blending, granulation, compression, and coating processes.
Browse courses on
MATLAB
Show steps
- Choose a software platform for simulation (MATLAB or Python).
- Gather data and parameters for the different process units.
- Develop and implement the simulation model.
- Validate the model by comparing simulation results with experimental data.
- Use the model to optimize the continuous production process.
Interactive simulation of a continuous manufacturing process
Show steps
Create an interactive simulation that allows users to visualize and understand the key steps involved in continuous manufacturing.
Browse courses on
Interactive Simulations
Show steps
- Choose a software platform for creating interactive simulations (e.g., Unity or Processing).
- Design and implement a graphical user interface for the simulation.
- Develop the simulation logic to model the continuous manufacturing process.
Proposal for implementing continuous manufacturing in a pharmaceutical plant
Show steps
Develop a comprehensive proposal outlining the benefits and feasibility of implementing continuous manufacturing in a pharmaceutical plant setting.
Browse courses on
Implementation Planning
Show steps
- Analyze the current manufacturing process and identify opportunities for improvement.
- Research and gather data on the benefits and challenges of continuous manufacturing.
- Develop a detailed implementation plan, including timelines and resource requirements.
Career center
Pharmaceutical Engineer
Process Development Scientist
Manufacturing Engineer
Production Manager
Process Engineer
Quality Assurance Manager
Quality Control Manager
Production Supervisor
Validation Engineer
Validation Specialist
Technical Sales Representative
Research Scientist
Research Associate
Technical Writer
Chemical Engineer
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