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Nicolai Jacob Wewer Albrechtsen and Lise Lotte Gluud

Non-Alcoholic Fatty Liver Disease (NAFLD) is a global problem, affecting up to 25% of all individuals. The disease not only increases the risk of liver disease, but also of cardiovascular disease and liver cancer.

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Non-Alcoholic Fatty Liver Disease (NAFLD) is a global problem, affecting up to 25% of all individuals. The disease not only increases the risk of liver disease, but also of cardiovascular disease and liver cancer.

During this course, you will learn the essentials of NAFLD. We will begin with an introduction to the physiology of the human liver followed by epidemiology, pathophysiology, clinical medicine, and genetics. Diagnosing NAFLD based on blood tests, diagnostic imaging and histology will be discussed. Complications and treatment options will also be covered in this course including the link between NAFLD and the development of diabetes. Finally, experts will discuss data driven identification of new biomarkers by omics technologies.

After completing this course, you will have a broad knowledge about NAFLD ranging from the aetiology and pathophysiology to bedside examinations and treatments.

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What's inside

Syllabus

The Liver - Physiology and Disease
The liver contributes to overall body homeostasis through several biochemical processes and without these functions we cannot maintain life. In the first lectures, Professor Jens Juul Holst will discuss the physiology of the human liver focusing on biochemical concepts as gluconeogenesis, glycogenolysis, lipid and amino acid metabolism. The videos will also cover how external hormonal systems such as pancreatic islets regulate liver metabolism. After completing module 1 you will have a broad and basic understanding of the physiology and pathophysiology of the liver. In the subsequent modules, we will build on top of module 1 by exploring fatty liver disease.
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Causes
What causes non-alcoholic fatty liver disease? This is the core question of module 2. We will kickstart this module by reviewing epidemiological data on non-alcoholic fatty liver disease by professor Peter Jepsen. In the second half, professor Bente Kiens will dig into which nutrients that may drive fat infiltration of the liver. The diversity in the risk of developing non-alcoholic fatty liver disease and NASH will be discussed from a genetic approach by doctor Stefan Stender.
Pathophysiological aspects
Professor Henning Grønbæk will commence module 3 with an overview of the multiple hit hypothesis followed by Hendrik Vilstrup who will describe how the liver function is affected in patients with NAFLD.
Diagnostics
Professors Flemming Bendtsen and Lise Lotte Gluud will discuss how to diagnose non-alcoholic fatty liver disease with or without fibrosis by non-invasive tests and describe when additional tests including histological assessment is required. Professor Mogens Vyberg will take us into the world of liver diagnostic by zooming in on the histological traits of liver tissue from patients with non-alcoholic fatty liver disease. The module will be concluded by perspectives on how ‘omics’ technologies such as protemics may contribute to identification of novel biomarkers in a lecture by Associate Professor Nicolai J. Wewer Albrechtsen and an interview with Professor Matthias Mann.
Treatment
Exercise is an important tool to improve the health of your liver. How exercise affect your liver will be introduced by Professor Bente Klarlund Pedersen and Associate Professor Nicolai J. Wewer Albrechtsen. Personal Trainer Samantha Mølgaard will give a practical guide on how to ‘exercise to improve your liver’. The evidence concerning the pharmacological treatment of non-alcoholic fatty liver disease is growing rapidly. Professor Guruprasad Aithal will introduce us to the current evidence and provide an insight into future drugs developed specifically for the treatment of non-alcoholic fatty liver disease.
Complications and Perspective
In the final module, Professor Henning Grønbæk will discuss the close relation between non-alcoholic fatty liver disease and type 2 diabetes. Furthermore, why it is important to screen individuals with type 2 diabetes for non-alcoholic fatty liver disease. Professor Jonel Trebicka will discuss the management of patients who have developed cirrhosis due to non-alcoholic fatty liver disease. Finally, Professor Lise lotte Gluud and Associate Professor Nicolai J. Wewer Albrechtsen will revisit some general aspects of non-alcoholic fatty liver disease and discuss its future aspects.

Good to know

Know what's good
, what to watch for
, and possible dealbreakers
Teaches fundamentals of non-alcoholic fatty liver disease and its related pathologies and treatments
Appropriate for healthcare professionals, students, and those interested in liver disease
Developed by recognized experts in liver disease
Covers the latest research and advancements in NAFLD
Provides a comprehensive overview of NAFLD from basic concepts to advanced topics
Requires participants to bring foundational knowledge in biochemistry, liver physiology, and medicine

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Reviews summary

Fundamentals of nafld

According to students, Non-Alcoholic Fatty Liver Disease - The Essentials is a highly informative and well-presented course providing learners an excellent foundation in Non-Alcoholic Fatty Liver Disease (NAFLD) diagnosis, treatment, and risk factors. This course is easy to understand, engaging, and helped learners progress in their understanding of NAFLD. The course is also backed by the latest research and is taught by knowledgeable professors. Overall, learners generally found the course materials and discussions to be very professional and thorough.
Helpful Course
"This is the helpful course with many necessary information for everyone to widen the understanding about Non-Alcoholic Fatty Liver Disease."
"It was really very informative"
"good."
Well Presented Course
"well presented by all experts."
"a well organized and nicely presented introductory level course"
"Absolutely great. Very thorough and well designed."
Excellent Learning Content
"Excellent course- many thanks, I will definately use what I have learnt in my clinical practise."
"Very informative and helpfull. Thank you for your course."
"Excelene"
Knowledgeable Professors
"Very comprehensive and expert presenters"
"Excellent, informative course. I recommend for all primary care physicians."
"Highly knowledgeable professors."
Informative Course
"Very informative! "
"I really enjoyed learning about NAFLD."
"v​ery interesting course "

Activities

Be better prepared before your course. Deepen your understanding during and after it. Supplement your coursework and achieve mastery of the topics covered in Non-Alcoholic Fatty Liver Disease – The Essentials with these activities:
Review Physiology and Pathophysiology of the Liver
Understanding the basics of liver function will provide a strong foundation for learning about NAFLD.
Show steps
  • Review relevant chapters in a textbook on human physiology or hepatology.
  • Attend a lecture or seminar on liver physiology.
  • Consult with a healthcare professional or researcher in the field of hepatology.
Practice liver disease diagnosis using case studies
Reinforce your diagnostic skills by applying knowledge to real-world scenarios.
Browse courses on Diagnostics
Show steps
  • Access online case studies or textbooks with liver disease cases.
  • Analyze the provided patient history, symptoms, and test results.
  • Determine the most likely diagnosis and explain your reasoning.
Practice problem sets
Reinforce your understanding of the concepts covered in the course by completing practice problem sets.
Show steps
  • Download the problem sets from the course website.
  • Set aside dedicated time each week to work on the problems.
  • Start by attempting the problems on your own.
  • Review your work and compare your answers to the provided solutions.
  • Seek help from the instructor or classmates if needed.
Five other activities
Expand to see all activities and additional details
Show all eight activities
Follow video tutorials on NAFLD
Supplement your learning by watching video tutorials that provide in-depth explanations of NAFLD and its management.
Show steps
  • Search for reputable sources of video tutorials on NAFLD.
  • Select tutorials that cover topics relevant to the course.
  • Take notes or summarize key points while watching the tutorials.
  • Apply what you learn from the tutorials to your assignments and discussions.
Participate in a Discussion Forum on NAFLD
Engaging in discussions with peers will expose you to different perspectives and enhance your understanding of NAFLD.
Show steps
  • Join an online discussion forum on NAFLD.
  • Post questions and comments on the discussion forum.
  • Read and respond to posts from other members of the discussion forum.
Volunteer at a Liver Clinic
Volunteering at a liver clinic will provide you with valuable hands-on experience in the diagnosis and management of NAFLD.
Show steps
  • Contact a liver clinic and inquire about volunteer opportunities.
  • Complete any necessary training or orientation.
  • Assist with patient care under the supervision of a healthcare professional.
Design an educational pamphlet on lifestyle modifications for NAFLD
Apply your understanding of NAFLD treatment options by creating a resource for patients.
Browse courses on Treatment
Show steps
  • Gather information on dietary recommendations, exercise guidelines, and other lifestyle modifications for NAFLD.
  • Design a visually appealing and easy-to-understand pamphlet.
  • Include clear instructions and practical tips for patients to follow.
Volunteer at a local clinic or organization supporting liver health
Gain practical experience and contribute to the community while reinforcing your knowledge of NAFLD.
Show steps
  • Identify local clinics or organizations that provide services related to liver health.
  • Contact the organization and inquire about volunteer opportunities.
  • Participate in activities such as patient education, support group facilitation, or administrative tasks.

Career center

Learners who complete Non-Alcoholic Fatty Liver Disease – The Essentials will develop knowledge and skills that may be useful to these careers:
Research Scientist
Understanding the intricacies of Non-Alcoholic Fatty Liver Disease (NAFLD) is paramount for Research Scientists in the field of hepatology. This course offers a comprehensive exploration of NAFLD's causes, pathophysiology, and diagnostics, providing you with a solid foundation for conducting research. The knowledge gained will enhance your ability to contribute to the development of innovative therapies and improve patient care for individuals with NAFLD.
Doctor
This course deepens your knowledge of Non-Alcoholic Fatty Liver Disease (NAFLD), empowering you to diagnose and treat this prevalent condition effectively. As a Doctor, understanding NAFLD's causes, pathophysiology, and management is crucial for providing comprehensive patient care. This course equips you with the knowledge to confidently manage NAFLD, improving patient outcomes and advancing your expertise in hepatology.
Registered Nurse
This course delves into the causes, pathophysiology, and diagnostics of Non-Alcoholic Fatty Liver Disease (NAFLD). As a Registered Nurse, understanding the complexities of NAFLD equips you to assess, monitor, and provide appropriate care for patients with liver diseases. The knowledge gained from this course will empower you to effectively manage the complexities of NAFLD, contributing to improved patient outcomes and reducing the risk of complications.
Integrative Nutrition Health Coach
Non-Alcoholic Fatty Liver Disease (NAFLD) is increasingly common, making it important for Integrative Nutrition Health Coaches to understand its causes and management. This course provides an in-depth exploration of NAFLD's causes, pathophysiology, and treatment options, with a focus on nutrition and lifestyle interventions. The knowledge gained will empower you to provide holistic guidance, create personalized plans, and support clients in managing their condition effectively.
Physician Assistant
As a Physician Assistant, staying abreast of Non-Alcoholic Fatty Liver Disease (NAFLD) is crucial for providing comprehensive patient care. This course offers an in-depth exploration of NAFLD's causes, pathophysiology, and treatment options. The knowledge gained will empower you to effectively assist physicians in diagnosing and managing NAFLD, improving patient outcomes and advancing your role in the healthcare team.
Dietitian
Understanding the nutritional aspects of Non-Alcoholic Fatty Liver Disease (NAFLD) is crucial for Dietitians. This course provides an in-depth understanding of the causes, pathophysiology, and dietary management of NAFLD. The knowledge gained will empower you to provide personalized dietary counseling, create tailored meal plans, and support patients in managing their condition effectively, leading to improved patient outcomes and well-being.
Pharmacist
As a Pharmacist, staying abreast of Non-Alcoholic Fatty Liver Disease (NAFLD) is essential to provide optimal patient care. This course offers an in-depth exploration of NAFLD's causes, pathophysiology, and treatment options. The knowledge gained will empower you to effectively counsel patients, collaborate with healthcare providers, and contribute to improving medication adherence, leading to better patient outcomes.
Medical Researcher
As a Medical Researcher in the field of Non-Alcoholic Fatty Liver Disease (NAFLD), understanding the latest research and advancements is paramount. This course offers a comprehensive exploration of NAFLD's causes, pathophysiology, and treatment options. The knowledge gained will empower you to conduct cutting-edge research, contribute to the development of new therapies, and improve patient outcomes.
Exercise Physiologist
Non-Alcoholic Fatty Liver Disease (NAFLD) is often associated with obesity and metabolic dysfunction. As an Exercise Physiologist, understanding the role of exercise in managing NAFLD is crucial. This course provides an in-depth exploration of NAFLD's causes, pathophysiology, and treatment options, with a focus on the benefits of exercise. The knowledge gained will empower you to develop tailored exercise programs, educate patients, and improve patient outcomes.
Health Educator
Understanding the causes, symptoms, and management of Non-Alcoholic Fatty Liver Disease (NAFLD) is essential for Health Educators. This course offers a comprehensive exploration of NAFLD, providing you with the knowledge to effectively educate and empower individuals and communities. The skills gained will enhance your ability to promote healthy lifestyles, reduce risk factors, and improve the overall health of populations affected by NAFLD.
Patient Advocate
As a Patient Advocate for individuals with Non-Alcoholic Fatty Liver Disease (NAFLD), understanding the complexities of the condition is paramount. This course provides an in-depth exploration of NAFLD's causes, pathophysiology, and treatment options. The knowledge gained will empower you to effectively support patients, navigate the healthcare system, and advocate for their rights, contributing to improved patient outcomes and quality of life.
Epidemiologist
As an Epidemiologist, understanding the prevalence, risk factors, and outcomes of Non-Alcoholic Fatty Liver Disease (NAFLD) is vital for developing effective public health strategies. This course offers an in-depth exploration of NAFLD's epidemiology, allowing you to analyze data, identify trends, and inform policies. The knowledge gained will empower you to contribute to the prevention and management of this prevalent condition on a population level.
Healthcare Administrator
Non-Alcoholic Fatty Liver Disease (NAFLD) is becoming increasingly prevalent, making it essential for Healthcare Administrators to understand its impact on healthcare systems. This course provides an in-depth exploration of NAFLD's causes, pathophysiology, and treatment options. The knowledge gained will enable you to make informed decisions, allocate resources effectively, and develop policies that improve patient care and outcomes.
Clinical Research Coordinator
Understanding the complexities of Non-Alcoholic Fatty Liver Disease (NAFLD) is essential for Clinical Research Coordinators involved in clinical trials. This course provides an in-depth exploration of NAFLD's causes, pathophysiology, and treatment options. The knowledge gained will empower you to effectively manage clinical trials, ensure patient safety, and contribute to the advancement of research in this field.
Medical Writer
Non-Alcoholic Fatty Liver Disease (NAFLD) is a growing concern, making it essential for Medical Writers to stay informed about the latest research and developments. This course offers a comprehensive exploration of NAFLD's causes, pathophysiology, and treatment options. The knowledge gained will enhance your ability to create accurate and engaging content that educates patients and healthcare professionals, contributing to improved disease management and public health.

Reading list

We've selected seven books that we think will supplement your learning. Use these to develop background knowledge, enrich your coursework, and gain a deeper understanding of the topics covered in Non-Alcoholic Fatty Liver Disease – The Essentials.
Provides a comprehensive overview of liver disease in children, including NAFLD. It valuable resource for pediatricians and other healthcare professionals who care for children with liver disease.
Serves as a comprehensive textbook on liver diseases, including NAFLD. Offers in-depth coverage of pathogenesis, diagnosis, and management strategies.
This comprehensive textbook provides a detailed overview of the liver, its functions, and diseases. While it does not focus specifically on NAFLD, it includes several chapters on liver metabolism and fatty liver disease, which would be valuable background reading.
Provides a concise overview of nonalcoholic fatty liver disease for patients and families. It valuable resource for patients and families who need to understand the basics of this condition and how to manage it.
Provides a comprehensive overview of the molecular biology of the cell. The book is well-written and easy to read, making it a valuable resource for both students and researchers.
Provides a concise overview of NAFLD for clinicians. It valuable resource for clinicians who need to understand the basics of this condition and how to manage it.

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