This course begins with a review of routes of administration, ADME (absorption, distribution, metabolism, & excretion), and the use of in vivo drug concentration-time data to determine key pharmacokinetic parameters, like volume of distribution, half-life and clearance. The course then emphasizes in vitro assays that allow rapid prediction of ADME and PK properties for evaluation of new compounds. The later stages of the course focus on how drug discovery teams study this PK/PD relationship, as well as dose size and frequency predictions which ultimately assist in selection of a compound for advancement into the clinic.
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This course begins with a review of routes of administration, ADME (absorption, distribution, metabolism, & excretion), and the use of in vivo drug concentration-time data to determine key pharmacokinetic parameters, like volume of distribution, half-life and clearance. The course then emphasizes in vitro assays that allow rapid prediction of ADME and PK properties for evaluation of new compounds. The later stages of the course focus on how drug discovery teams study this PK/PD relationship, as well as dose size and frequency predictions which ultimately assist in selection of a compound for advancement into the clinic.
This course begins with a review of routes of administration, ADME (absorption, distribution, metabolism, & excretion), and the use of in vivo drug concentration-time data to determine key pharmacokinetic parameters, like volume of distribution, half-life and clearance. The course then emphasizes in vitro assays that allow rapid prediction of ADME and PK properties for evaluation of new compounds. The later stages of the course focus on how drug discovery teams study this PK/PD relationship, as well as dose size and frequency predictions which ultimately assist in selection of a compound for advancement into the clinic.
This course is suitable for life scientists, clinicians, and individuals from fields that support drug discovery (e.g., patents, finance, licensing, etc.) interested in learning more about the pharmaceutical/biotechnology sector. Advanced undergraduate coursework or practical familiarity/working knowledge in biological sciences and organic chemistry is recommended.
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Syllabus
Pharmacokinetics, part 1
Welcome, by the end of the course students will be able to: Summarize the key concepts of pharmacokinetics (PK), ADME (Absorption, Distribution, Metabolism, and Excretion), volume of distribution, half-life and clearance. Differentiate between different routes of drug administration and their impact on PK parameters. Define and describe the influence of transporters, plasma protein binding (PPB) and drug-drug interactions (DDIs) on the PK of a drug molecule. Explain how PK/PD relationships are derived and their importance for defining the anticipated human dose.
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Syllabus
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Activities
Review basic principles of organic chemistry
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Refresh your understanding of the fundamental concepts of organic chemistry, preparing you to better grasp the structure and properties of drugs.
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Organic Chemistry
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Review your notes or textbooks from a previous organic chemistry course.
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Practice drawing and naming organic molecules.
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Solve practice problems related to organic chemistry concepts.
Join a study group
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Engage in discussions and collaborate with peers to reinforce concepts, clarify doubts, and expand your understanding of pharmacokinetics and pharmacodynamics.
Browse courses on
Pharmacokinetics
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-
Find a group of peers with similar interests.
-
Meet regularly to discuss course materials and share insights.
-
Work together on assignments and projects.
Solve pharmacokinetic calculations
Show steps
Practice applying pharmacokinetic principles to solve real-world problems, enhancing your understanding of drug absorption, distribution, metabolism, and excretion.
Browse courses on
Pharmacokinetics
Show steps
-
Identify the appropriate pharmacokinetic parameters to calculate.
-
Use appropriate equations and data to perform the calculations.
-
Interpret the results and draw conclusions.
Four other activities
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Explore online tutorials on pharmacokinetic modeling
Show steps
Enhance your understanding of pharmacokinetic modeling techniques through interactive tutorials, solidifying your grasp of drug absorption, distribution, metabolism, and excretion.
Browse courses on
Pharmacokinetics
Show steps
-
Identify reputable online resources offering tutorials on pharmacokinetic modeling.
-
Follow the tutorials, taking notes and experimenting with different parameters.
-
Apply the techniques to real-world scenarios to test your understanding.
Create a presentation on a pharmacokinetic topic
Show steps
Solidify your understanding of pharmacokinetic concepts by creating a presentation that explains a specific topic in depth, enhancing your communication and critical thinking skills.
Browse courses on
Pharmacokinetics
Show steps
-
Choose a specific pharmacokinetic topic to present on.
-
Research the topic thoroughly and gather relevant data.
-
Organize the presentation logically and visually.
-
Practice delivering the presentation to improve clarity and impact.
Design a pharmacokinetic simulation model
Show steps
Develop a practical understanding of pharmacokinetic principles by creating a simulation model that predicts drug concentrations over time, strengthening your ability to analyze and interpret pharmacokinetic data.
Browse courses on
Pharmacokinetics
Show steps
-
Identify the appropriate software or platform for the simulation.
-
Design the model structure, including compartments, parameters, and equations.
-
Validate the model using experimental data or literature.
-
Use the model to predict drug concentrations and evaluate different scenarios.
Contribute to open-source pharmacokinetic projects
Show steps
Gain hands-on experience and contribute to the scientific community by participating in open-source pharmacokinetic projects, deepening your understanding of real-world applications.
Browse courses on
Pharmacokinetics
Show steps
-
Identify open-source pharmacokinetic projects on platforms like GitHub.
-
Contribute to the project by reporting bugs, fixing issues, or adding new features.
-
Collaborate with other contributors to enhance the project's capabilities.
Review basic principles of organic chemistry
Show steps
Refresh your understanding of the fundamental concepts of organic chemistry, preparing you to better grasp the structure and properties of drugs.
Browse courses on
Organic Chemistry
Show steps
- Review your notes or textbooks from a previous organic chemistry course.
- Practice drawing and naming organic molecules.
- Solve practice problems related to organic chemistry concepts.
Join a study group
Show steps
Engage in discussions and collaborate with peers to reinforce concepts, clarify doubts, and expand your understanding of pharmacokinetics and pharmacodynamics.
Browse courses on
Pharmacokinetics
Show steps
- Find a group of peers with similar interests.
- Meet regularly to discuss course materials and share insights.
- Work together on assignments and projects.
Solve pharmacokinetic calculations
Show steps
Practice applying pharmacokinetic principles to solve real-world problems, enhancing your understanding of drug absorption, distribution, metabolism, and excretion.
Browse courses on
Pharmacokinetics
Show steps
- Identify the appropriate pharmacokinetic parameters to calculate.
- Use appropriate equations and data to perform the calculations.
- Interpret the results and draw conclusions.
Explore online tutorials on pharmacokinetic modeling
Show steps
Enhance your understanding of pharmacokinetic modeling techniques through interactive tutorials, solidifying your grasp of drug absorption, distribution, metabolism, and excretion.
Browse courses on
Pharmacokinetics
Show steps
- Identify reputable online resources offering tutorials on pharmacokinetic modeling.
- Follow the tutorials, taking notes and experimenting with different parameters.
- Apply the techniques to real-world scenarios to test your understanding.
Create a presentation on a pharmacokinetic topic
Show steps
Solidify your understanding of pharmacokinetic concepts by creating a presentation that explains a specific topic in depth, enhancing your communication and critical thinking skills.
Browse courses on
Pharmacokinetics
Show steps
- Choose a specific pharmacokinetic topic to present on.
- Research the topic thoroughly and gather relevant data.
- Organize the presentation logically and visually.
- Practice delivering the presentation to improve clarity and impact.
Design a pharmacokinetic simulation model
Show steps
Develop a practical understanding of pharmacokinetic principles by creating a simulation model that predicts drug concentrations over time, strengthening your ability to analyze and interpret pharmacokinetic data.
Browse courses on
Pharmacokinetics
Show steps
- Identify the appropriate software or platform for the simulation.
- Design the model structure, including compartments, parameters, and equations.
- Validate the model using experimental data or literature.
- Use the model to predict drug concentrations and evaluate different scenarios.
Contribute to open-source pharmacokinetic projects
Show steps
Gain hands-on experience and contribute to the scientific community by participating in open-source pharmacokinetic projects, deepening your understanding of real-world applications.
Browse courses on
Pharmacokinetics
Show steps
- Identify open-source pharmacokinetic projects on platforms like GitHub.
- Contribute to the project by reporting bugs, fixing issues, or adding new features.
- Collaborate with other contributors to enhance the project's capabilities.
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