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Erland Stevens

In this course about ADME and PK, students will learn how the PK properties of drug candidate are analyzed to guide decisions by the entire drug discovery team. The three-week course starts with the use of drug concentration-time data points to determine the key pharmacokinetic parameters of a compound. The second week focuses on the types of laboratory and animal studies that assist in the prediction of the human PK properties of a compound. In the final week, students will learn how the PK properties are used with efficacy data to predict the human efficacious dose and assist in drug formulation.

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In this course about ADME and PK, students will learn how the PK properties of drug candidate are analyzed to guide decisions by the entire drug discovery team. The three-week course starts with the use of drug concentration-time data points to determine the key pharmacokinetic parameters of a compound. The second week focuses on the types of laboratory and animal studies that assist in the prediction of the human PK properties of a compound. In the final week, students will learn how the PK properties are used with efficacy data to predict the human efficacious dose and assist in drug formulation.

Students in the course should understand human anatomy and cell structure. Students should also be comfortable with algebraic expressions, including logarithmic and exponential functions. A fundamental understanding of the structure of organic molecules and their functional groups will also be helpful. The course is designed in modules. Each module opens with a short video on a selected topic. The module continues with a short reading or exercise with an assessment activity. Each module will require approximately 1 hour to complete, and the course includes 15 modules. Two approaches to the course are recommended. One, a student might spend an hour per day on the course and complete all 15 modules in approximately three weeks. Two, a student with additional available time may be able to work through the entire course in just a single week or over an extended weekend.

Students signed up for the Audit Track have access to the instructional video materials. Students enrolled through the Verified Track have access to the instructional videos, the readings and activities, the assessments, as well as selected additional videos related to the primary instructional videos.

What you'll learn

  • methods for determining the key PK properties from drug concentration-time data points

  • distinctions between common routes of administration of various drugs

  • laboratory techniques for studying ADME properties of compounds in vitro

  • common in vivo PK studies for early prediction of human PK properties

  • differences in PK properties between small molecule drugs and biologics

  • models for understanding how PK and efficacy together can help determine the dosing regimen of a drug

Good to know

Know what's good
, what to watch for
, and possible dealbreakers
Covers common routes of administration, laboratory techniques, and in vivo PK studies commonly seen in drug discovery
Introduces different laboratory and animal studies to understand the ADME properties of compounds
Taught by an expert in the field, Erland Stevens
Useful for those seeking knowledge in drug discovery and development
Provides an understanding of how PK properties guide decisions for drug discovery teams
Requires students to have a basic understanding of human anatomy, cell structure, algebra, and organic chemistry
The reading materials are only available for students enrolled in the Verified Track

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Activities

Be better prepared before your course. Deepen your understanding during and after it. Supplement your coursework and achieve mastery of the topics covered in Introduction to Pharmacokinetics: From ADME to PK/PD with these activities:
Review human anatomy and cell structure
Refresh already acquired knowledge of human anatomy and cell structure to better prepare for the advanced topics on PK properties in the course.
Browse courses on Human Anatomy
Show steps
  • Review the chapters on human anatomy and cell structure from a previous biology textbook
  • Complete 10 practice questions on each topic
Review algebra and logarithms
Complete a series of online tutorials to refresh working knowledge of algebra and logarithms to prepare for key concepts introduced in the course.
Browse courses on Algebra
Show steps
  • Visit Khan Academy Algebra I and Algebra II courses
  • Complete 10 practice problems for each skill
Participate in online discussion forums
Engage with other students through online discussion forums to exchange insights, ask questions, and reinforce understanding of PK concepts.
Show steps
  • Identify relevant online discussion forums
  • Actively participate in discussions by asking questions, sharing perspectives, and providing feedback
  • Collaborate with peers to solve problems and clarify concepts
Four other activities
Expand to see all activities and additional details
Show all seven activities
Create a mind map of PK processes
Create a visual representation of the key PK processes to reinforce understanding and identify relationships between concepts.
Show steps
  • Identify the major PK processes covered in the course
  • Use a mind mapping tool or software to create a visual representation of these processes, including their interconnections
  • Add details and examples to the mind map as you progress through the course
Solve practice problems on PK calculations
Engage in repeated practice of PK calculations to improve accuracy, speed, and confidence in applying course concepts.
Show steps
  • Access online resources or textbooks for practice problems on PK calculations
  • Solve a set of problems, checking your answers against provided solutions
  • Identify areas where you struggle and focus on practicing those specific concepts
Develop a poster presentation on a specific PK topic
Research a specific PK topic in depth and present your findings in a clear and engaging poster format to enhance comprehension and communication skills.
Show steps
  • Select a PK topic of interest
  • Conduct thorough research using reputable sources
  • Design a visually appealing and informative poster that effectively communicates your findings
  • Present your poster to classmates or a broader audience (optional)
Build a PK simulation model
Engage in a hands-on project to build a PK simulation model, applying course concepts and developing problem-solving and analytical skills.
Show steps
  • Choose a PK scenario or drug of interest
  • Develop a conceptual model of the PK processes involved
  • Translate the conceptual model into a simulation model using software or programming
  • Validate the model by comparing its predictions to experimental data (if available)
  • Use the model to explore different scenarios and make predictions

Career center

Learners who complete Introduction to Pharmacokinetics: From ADME to PK/PD will develop knowledge and skills that may be useful to these careers:
Pharmacokineticist
Pharmacokineticists study the absorption, distribution, metabolism, and excretion of drugs in the body. This course provides a strong foundation in the principles of pharmacokinetics, which is essential for understanding how drugs work and how to develop new drugs. The course covers topics such as drug concentration-time data analysis, laboratory and animal studies for predicting human PK properties, and PK/PD modeling. This knowledge is essential for pharmacokineticists who are responsible for designing and conducting studies to evaluate the PK properties of new drugs.
Clinical Pharmacologist
Clinical pharmacologists study the effects of drugs in humans. This course provides a strong foundation in the principles of pharmacokinetics, which is essential for understanding how drugs work and how to develop new drugs. The course covers topics such as drug concentration-time data analysis, laboratory and animal studies for predicting human PK properties, and PK/PD modeling. This knowledge is essential for clinical pharmacologists who are responsible for designing and conducting studies to evaluate the safety and efficacy of new drugs.
Toxicologist
Toxicologists study the effects of chemicals on living organisms. This course provides a strong foundation in the principles of pharmacokinetics, which is essential for understanding how chemicals are absorbed, distributed, metabolized, and excreted in the body. The course covers topics such as drug concentration-time data analysis, laboratory and animal studies for predicting human PK properties, and PK/PD modeling. This knowledge is essential for toxicologists who are responsible for assessing the safety of new chemicals.
Drug Development Scientist
Drug development scientists are responsible for the development of new drugs. This course provides a strong foundation in the principles of pharmacokinetics, which is essential for understanding how drugs work and how to develop new drugs. The course covers topics such as drug concentration-time data analysis, laboratory and animal studies for predicting human PK properties, and PK/PD modeling. This knowledge is essential for drug development scientists who are responsible for designing and conducting studies to evaluate the safety and efficacy of new drugs.
Medical Writer
Medical writers are responsible for writing about drugs and other medical topics. This course provides a strong foundation in the principles of pharmacokinetics, which is essential for understanding how drugs work and how to develop new drugs. The course covers topics such as drug concentration-time data analysis, laboratory and animal studies for predicting human PK properties, and PK/PD modeling. This knowledge is essential for medical writers who are responsible for writing about the safety and efficacy of new drugs.
Regulatory Affairs Specialist
Regulatory affairs specialists are responsible for ensuring that drugs are safe and effective before they are marketed. This course provides a strong foundation in the principles of pharmacokinetics, which is essential for understanding how drugs work and how to develop new drugs. The course covers topics such as drug concentration-time data analysis, laboratory and animal studies for predicting human PK properties, and PK/PD modeling. This knowledge is essential for regulatory affairs specialists who are responsible for reviewing and evaluating data on the safety and efficacy of new drugs.
Healthcare Consultant
Healthcare consultants provide advice to healthcare organizations on a variety of topics, including drug development and marketing. This course provides a strong foundation in the principles of pharmacokinetics, which is essential for understanding how drugs work and how to develop new drugs. The course covers topics such as drug concentration-time data analysis, laboratory and animal studies for predicting human PK properties, and PK/PD modeling. This knowledge is essential for healthcare consultants who are responsible for advising healthcare organizations on the safety and efficacy of new drugs.
Pharmaceutical Sales Representative
Pharmaceutical sales representatives are responsible for selling drugs to doctors and other healthcare professionals. This course provides a strong foundation in the principles of pharmacokinetics, which is essential for understanding how drugs work and how to develop new drugs. The course covers topics such as drug concentration-time data analysis, laboratory and animal studies for predicting human PK properties, and PK/PD modeling. This knowledge is essential for pharmaceutical sales representatives who are responsible for educating doctors and other healthcare professionals about the safety and efficacy of new drugs.
Biostatistician
Biostatisticians use statistical methods to analyze data in the biomedical field. This course provides a strong foundation in the principles of pharmacokinetics, which is essential for understanding how drugs work and how to develop new drugs. The course covers topics such as drug concentration-time data analysis, laboratory and animal studies for predicting human PK properties, and PK/PD modeling. This knowledge is essential for biostatisticians who are responsible for analyzing data on the safety and efficacy of new drugs.
Epidemiologist
Epidemiologists study the causes and distribution of disease in populations. This course provides a strong foundation in the principles of pharmacokinetics, which is essential for understanding how drugs work and how to develop new drugs. The course covers topics such as drug concentration-time data analysis, laboratory and animal studies for predicting human PK properties, and PK/PD modeling. This knowledge is essential for epidemiologists who are responsible for studying the safety and efficacy of new drugs in populations.
Science Writer
Science writers write about science for a variety of audiences. This course provides a strong foundation in the principles of pharmacokinetics, which is essential for understanding how drugs work and how to develop new drugs. The course covers topics such as drug concentration-time data analysis, laboratory and animal studies for predicting human PK properties, and PK/PD modeling. This knowledge is essential for science writers who are responsible for writing about the safety and efficacy of new drugs.
Health Economist
Health economists study the cost-effectiveness of healthcare interventions. This course provides a strong foundation in the principles of pharmacokinetics, which is essential for understanding how drugs work and how to develop new drugs. The course covers topics such as drug concentration-time data analysis, laboratory and animal studies for predicting human PK properties, and PK/PD modeling. This knowledge is essential for health economists who are responsible for evaluating the cost-effectiveness of new drugs.
Patent Attorney
Patent attorneys help clients obtain patents for their inventions. This course provides a strong foundation in the principles of pharmacokinetics, which is essential for understanding how drugs work and how to develop new drugs. The course covers topics such as drug concentration-time data analysis, laboratory and animal studies for predicting human PK properties, and PK/PD modeling. This knowledge is essential for patent attorneys who are responsible for drafting and prosecuting patent applications for new drugs.
Medical Librarian
Medical librarians help doctors and other healthcare professionals find information about drugs and other medical topics. This course provides a strong foundation in the principles of pharmacokinetics, which is essential for understanding how drugs work and how to develop new drugs. The course covers topics such as drug concentration-time data analysis, laboratory and animal studies for predicting human PK properties, and PK/PD modeling. This knowledge is essential for medical librarians who are responsible for helping doctors and other healthcare professionals find information about the safety and efficacy of new drugs.
Pharmacist
Pharmacists dispense drugs to patients and provide information about how to take them. This course provides a strong foundation in the principles of pharmacokinetics, which is essential for understanding how drugs work and how to develop new drugs. The course covers topics such as drug concentration-time data analysis, laboratory and animal studies for predicting human PK properties, and PK/PD modeling. This knowledge is essential for pharmacists who are responsible for dispensing drugs to patients and providing information about how to take them.

Reading list

We've selected four books that we think will supplement your learning. Use these to develop background knowledge, enrich your coursework, and gain a deeper understanding of the topics covered in Introduction to Pharmacokinetics: From ADME to PK/PD.
The course curriculum covers PK/PD modeling and simulation, making threlevant reference text for learners seeking in-depth knowledge of this topic.
Is written for academic settings, covering the theoretical and practical aspects of pharmacokinetics. It may be useful as a reference for understanding key concepts covered in the course.
Patrick's book will aid students in gaining a background in medicinal chemistry. This will give a deeper understanding of the upcoming topics on PK. is commonly used as a textbook for upper-level undergraduate and graduate courses across the globe.

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