Introduction to Translational Science from Coursera

Translational science seeks to speed up the process of moving research discoveries from the laboratory into healthcare practices. Numerous scientific and organizational roadblocks can act as obstacles along the path of translation and ultimately hinder the speed of progress in medical research. The National Center for Advancing Translational Sciences (NCATS) was established by the National Institutes of Health (NIH) to transform and accelerate the translational research process, with the intended result of getting treatments to more patients faster. The field of Translational Science aims to bridge these gaps by:

Developing new approaches, technologies, resources and models

Demonstrating the usefulness of new approaches, technologies, resources and models

Disseminating the resulting data, analyses, and methodologies to the broad scientific community

Introduction to Translational Science is an introductory course that provides students with a broad understanding of translational science, the types of research that are conducted under the translational science umbrella, and how this research impacts the public at large. The course will compare and contrast current impediments to clinical research with the potential of translational science and will include selected case studies from the University of Rochester.

What's inside

Syllabus

Translational Science - The Big Picture and T1 - Translation to Humans

The first lesson in Introduction to Translational Science provides an overview of the basic definitions and key concepts related to clinical and translational science and the CTSA program. Students will learn about the different stages of translational research and the roadblocks that impede progress across the spectrum.The second lesson in Introduction to Translational Science provides an introduction to T1 research which is research that translates findings from basic (laboratory) research to humans through developing treatments and interventions. T1 research is often conducted through observational studies, case studies, proof-of-concept studies, phase I clinical trials, and phase II clinical trials

T2 - Translation to Patients and T3 - Translation to Practice

The third lesson in Introduction to Translational Science provides an introduction to T2 research, which is research that translates findings from T1 research (humans) to patients. T2 research is often conducted through Phase III clinical trials, observational studies, evidence synthesis, and clinical guidelines development. The fourth lesson in Introduction to Translational Science provides an introduction to T3 research, which is research that translates findings from T2 research (patients) to actual clinical practices. T3 research is often conducted through Phase IV clinical trials, health services research, and clinical outcomes research.

T4 - Translation to Communities and Participating in Clinical and Translational Research

The fifth lesson of Introduction to Translational Science provides an introduction to T4 research, which is research that translates findings from practices (T3 research) to communities, both domestic and globally. T4 research is often conducted through prevention and outcome studies, mass screening studies, and health policy studies.The sixth lesson of Introduction to Translational Science provides an overview of how interested individuals can participate in clinical and translational research; as an independent research, as a clinical research professional, and as a study volunteer. The final segment of the module demonstrates what a typical study volunteer will encounter if they are selected to participate in a clinical trial.

Good to know

Know what's good

, what to watch for

, and possible dealbreakers

The course focuses on translational science, which is at the forefront of medical research and has the potential to revolutionize patient care

Taught by respected medical professionals with extensive experience in translational research, ensuring learners are exposed to cutting-edge knowledge and insights

Provides a comprehensive overview of translational science, encompassing its principles, methodologies, and impact on healthcare

Suitable for individuals interested in pursuing a career in translational research or seeking a deeper understanding of its role in healthcare innovation

May require a background in biomedical sciences or related fields to fully grasp the concepts presented

Utilizes a multi-modal approach with videos, readings, and interactive materials to enhance learning

Reviews summary

Translational science: lab to practice

Learners say this course is a great introduction to the field of translational science. It covers the spectrum of research and study types involved in the field and provides engaging interviews with researchers to contextualize the theory. Despite being introductory, learners say the content is rich and the included reading materials are informative and thought-provoking. It is highly recommended for anyone interested in the field, including those already enrolled in a science area or those looking for a basic understanding of translational science.

The included reading materials are informative and thought-provoking.

"The paradigm of research activities and milestones shown here is comprehensive and worth emulating (or, at the very least, considered) by research institutions, agencies and funders outside the United States."

"For people who are already enrolled in a science area it will be a very easy-to-catch course, and even if you are not, it is not a difficult subject."

"It is not a difficult subject."

This course is a good introduction to translational science.

"It is a great course for whom seek an introduction to the exciting field of Translational Science."

"It's a very interesting course although it is indeed very introductory."

"This course is a great introduction to the field of translational science."

The course presents diverse perspectives on translational science.

"The material is also rich with engaging examples that highlight the diverse and extensive research prowess and achievements of the institution hosting this course."

"This course really changed my view about how healthcare research is being addressed today."

"I have been communicating about translational and clinical medicine as part of my job but have no formal training in science or medicine, so found it very insightful to have a more in-depth introduction to the topic."

Interviews with researchers in the field provide valuable insights.

"Very informative and comprehensive course included detailed interviews with subject matter experts."

"The course shows the variety of how Translational Science is done."

"Having the interviews with researchers was really helpful to help contextualise the theory."

Activities

Be better prepared before your course. Deepen your understanding during and after it. Supplement your coursework and achieve mastery of the topics covered in Introduction to Translational Science with these activities:

Follow online tutorials on translational research software

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Enhance your proficiency in using software tools essential for translational research data analysis and management.

Browse courses on Data Analysis

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Identify a reputable online tutorial or course on translational research software
Follow the tutorial step-by-step, completing all exercises and assignments
Apply the software to a small-scale translational research project to gain practical experience

Solve translational research case studies

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Engage with real-world examples to reinforce your understanding of translational research principles and methodologies.

Browse courses on Translational Research

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Identify a translational research case study from a reputable source
Read and analyze the study, focusing on the research design, methods, and results
Critically evaluate the study's strengths and weaknesses
Summarize the key findings and implications for translational research

Develop a translational research research proposal

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Apply your knowledge of translational research principles to design and write a compelling research proposal that addresses an unmet clinical need.

Browse courses on Grant Writing

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Identify a research problem and develop a hypothesis
Design a research study to test your hypothesis, including methodology, data collection, and analysis plan
Draft a research proposal outlining your study design, objectives, and expected outcomes
Seek feedback from experts in the field and revise your proposal accordingly

Show all three activities

Career center

Learners who complete Introduction to Translational Science will develop knowledge and skills that may be useful to these careers:

Clinical Research Associate

Clinical Research Associates play a crucial role in the clinical research process, ensuring that clinical trials are conducted ethically and safely. This course provides a strong foundation in the principles and practices of translational science, which is essential for understanding the development and implementation of clinical trials. By gaining a comprehensive understanding of translational research, you will be well-equipped to manage clinical trials effectively and contribute to the advancement of medical research.

See salaries and explore the career path for Clinical Research Associate

Medical Science Liaison

Medical Science Liaisons serve as a bridge between pharmaceutical companies and healthcare providers, providing scientific information and support. This course will provide you with a deep understanding of translational research and its impact on clinical practice, enabling you to effectively communicate complex scientific concepts to healthcare professionals. By gaining knowledge of the different stages of translational research, you will be able to effectively translate research findings into practical applications, ultimately improving patient outcomes.

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Regulatory Affairs Specialist

Regulatory Affairs Specialists ensure that medical products meet regulatory requirements and are safe for public use. This course provides a comprehensive overview of the regulatory landscape for clinical research and medical devices, helping you to understand the complexities of regulatory processes. By gaining a solid foundation in translational research, you will be well-equipped to navigate the regulatory landscape effectively and ensure the safety and efficacy of medical products.

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Research Scientist

Research Scientists conduct scientific research to advance knowledge and develop new technologies. This course will provide you with a strong foundation in the principles and practices of translational research, enabling you to design and conduct research studies effectively. By gaining a comprehensive understanding of translational research, you will be well-equipped to contribute to the advancement of medical research and improve patient outcomes.

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Clinical Trial Manager

Clinical Trial Managers oversee the day-to-day operations of clinical trials, ensuring that they are conducted efficiently and in compliance with regulations. This course provides a comprehensive overview of the clinical trial process and the role of translational research in developing new treatments and interventions. By gaining a deep understanding of translational science, you will be well-equipped to manage clinical trials effectively and contribute to the advancement of medical research.

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Science Writer

Science Writers communicate complex scientific information to a non-scientific audience. This course provides a strong foundation in the principles and practices of translational research, enabling you to effectively translate scientific findings into clear and concise language. By gaining a comprehensive understanding of translational research, you will be well-equipped to write engaging and informative articles that increase public awareness of medical advancements.

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Healthcare Consultant

Healthcare Consultants provide advice and guidance to healthcare organizations on a variety of topics, including clinical research, regulatory affairs, and patient care. This course will provide you with a comprehensive understanding of the healthcare industry and the role of translational research in improving patient outcomes. By gaining knowledge of the different stages of translational research, you will be able to effectively advise healthcare organizations on how to implement new technologies and treatments.

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Biostatistician

Biostatisticians apply statistical methods to solve problems in healthcare and medical research. This course provides a strong foundation in the principles and practices of translational research, enabling you to effectively analyze and interpret clinical data. By gaining a comprehensive understanding of translational science, you will be well-equipped to contribute to the design and analysis of clinical trials and other research studies.

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Clinical Pharmacist

Clinical Pharmacists provide medication therapy management and counseling to patients. This course will provide you with a comprehensive overview of the drug development process and the role of translational research in developing new and improved treatments. By gaining a deep understanding of translational science, you will be well-equipped to provide patients with evidence-based medication therapy and counseling.

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Epidemiologist

Epidemiologists investigate the distribution and determinants of health-related states or events in specified populations. This course provides a comprehensive overview of the principles and practices of translational research, enabling you to effectively design and conduct epidemiological studies. By gaining a deep understanding of translational science, you will be well-equipped to contribute to the prevention and control of diseases.

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Patient Advocate

Patient Advocates represent the interests of patients and their families, ensuring that they have access to quality healthcare. This course will provide you with a deep understanding of the healthcare system and the role of translational research in improving patient outcomes. By gaining knowledge of the different stages of translational research, you will be able to effectively advocate for patients and ensure that they receive the best possible care.

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Nurse Practitioner

Nurse Practitioners provide healthcare services independently or in collaboration with physicians. This course will provide you with a comprehensive overview of the healthcare system and the role of translational research in improving patient outcomes. By gaining knowledge of the different stages of translational research, you will be able to effectively collaborate with physicians and other healthcare professionals to provide high-quality patient care.

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Physician Assistant

Physician Assistants provide healthcare services under the supervision of a physician. This course will provide you with a comprehensive overview of the healthcare system and the role of translational research in improving patient outcomes. By gaining knowledge of the different stages of translational research, you will be able to effectively collaborate with physicians and other healthcare professionals to provide high-quality patient care.

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Health Economist

Health Economists apply economic principles to analyze healthcare issues and policies. This course provides a comprehensive overview of the healthcare system and the role of translational research in improving patient outcomes. By gaining knowledge of the different stages of translational research, you will be able to effectively analyze the economic impact of new technologies and treatments.

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Social Worker

Social Workers provide support and services to individuals and families facing challenges. This course will provide you with a comprehensive understanding of the social determinants of health and the role of translational research in improving health equity. By gaining knowledge of the different stages of translational research, you will be able to effectively advocate for social policies and programs that improve the health and well-being of individuals and communities.

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Introduction to Translational Science

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Translational science: lab to practice

Activities

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