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Martin S. Zand, MD, PhD
Translational science seeks to speed up the process of moving research discoveries from the laboratory into healthcare practices. Numerous scientific and organizational roadblocks can act as obstacles along the path of translation and ultimately hinder the speed of progress in medical research. The National Center for Advancing Translational Sciences (NCATS) was established by the National Institutes of Health (NIH) to transform and accelerate the translational research process, with the intended result of getting treatments to more patients faster. The field of Translational Science aims to bridge these gaps by:
Read more
Translational science seeks to speed up the process of moving research discoveries from the laboratory into healthcare practices. Numerous scientific and organizational roadblocks can act as obstacles along the path of translation and ultimately hinder the speed of progress in medical research. The National Center for Advancing Translational Sciences (NCATS) was established by the National Institutes of Health (NIH) to transform and accelerate the translational research process, with the intended result of getting treatments to more patients faster. The field of Translational Science aims to bridge these gaps by:
Read more
Translational science seeks to speed up the process of moving research discoveries from the laboratory into healthcare practices. Numerous scientific and organizational roadblocks can act as obstacles along the path of translation and ultimately hinder the speed of progress in medical research. The National Center for Advancing Translational Sciences (NCATS) was established by the National Institutes of Health (NIH) to transform and accelerate the translational research process, with the intended result of getting treatments to more patients faster. The field of Translational Science aims to bridge these gaps by:
Developing new approaches, technologies, resources and models
Demonstrating the usefulness of new approaches, technologies, resources and models
Disseminating the resulting data, analyses, and methodologies to the broad scientific community
Introduction to Translational Science is an introductory course that provides students with a broad understanding of translational science, the types of research that are conducted under the translational science umbrella, and how this research impacts the public at large. The course will compare and contrast current impediments to clinical research with the potential of translational science and will include selected case studies from the University of Rochester.
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What's inside
Syllabus
Translational Science - The Big Picture and T1 - Translation to Humans
The first lesson in Introduction to Translational Science provides an overview of the basic definitions and key concepts related to clinical and translational science and the CTSA program. Students will learn about the different stages of translational research and the roadblocks that impede progress across the spectrum.The second lesson in Introduction to Translational Science provides an introduction to T1 research which is research that translates findings from basic (laboratory) research to humans through developing treatments and interventions. T1 research is often conducted through observational studies, case studies, proof-of-concept studies, phase I clinical trials, and phase II clinical trials
Read more
Syllabus
Translational Science - The Big Picture and T1 - Translation to Humans
The first lesson in Introduction to Translational Science provides an overview of the basic definitions and key concepts related to clinical and translational science and the CTSA program. Students will learn about the different stages of translational research and the roadblocks that impede progress across the spectrum.The second lesson in Introduction to Translational Science provides an introduction to T1 research which is research that translates findings from basic (laboratory) research to humans through developing treatments and interventions. T1 research is often conducted through observational studies, case studies, proof-of-concept studies, phase I clinical trials, and phase II clinical trials
Read more
T2 - Translation to Patients and T3 - Translation to Practice
The third lesson in Introduction to Translational Science provides an introduction to T2 research, which is research that translates findings from T1 research (humans) to patients. T2 research is often conducted through Phase III clinical trials, observational studies, evidence synthesis, and clinical guidelines development.
The fourth lesson in Introduction to Translational Science provides an introduction to T3 research, which is research that translates findings from T2 research (patients) to actual clinical practices. T3 research is often conducted through Phase IV clinical trials, health services research, and clinical outcomes research.
T4 - Translation to Communities and Participating in Clinical and Translational Research
The fifth lesson of Introduction to Translational Science provides an introduction to T4 research, which is research that translates findings from practices (T3 research) to communities, both domestic and globally. T4 research is often conducted through prevention and outcome studies, mass screening studies, and health policy studies.The sixth lesson of Introduction to Translational Science provides an overview of how interested individuals can participate in clinical and translational research; as an independent research, as a clinical research professional, and as a study volunteer. The final segment of the module demonstrates what a typical study volunteer will encounter if they are selected to participate in a clinical trial.
Good to know
Good to know
Know what's good ,
what to watch for , and
possible dealbreakers
The course focuses on translational science, which is at the forefront of medical research and has the potential to revolutionize patient care
Taught by respected medical professionals with extensive experience in translational research, ensuring learners are exposed to cutting-edge knowledge and insights
Provides a comprehensive overview of translational science, encompassing its principles, methodologies, and impact on healthcare
Suitable for individuals interested in pursuing a career in translational research or seeking a deeper understanding of its role in healthcare innovation
May require a background in biomedical sciences or related fields to fully grasp the concepts presented
Utilizes a multi-modal approach with videos, readings, and interactive materials to enhance learning
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Reviews summary
Translational science: lab to practice
Learners say this course is a great introduction to the field of translational science. It covers the spectrum of research and study types involved in the field and provides engaging interviews with researchers to contextualize the theory. Despite being introductory, learners say the content is rich and the included reading materials are informative and thought-provoking. It is highly recommended for anyone interested in the field, including those already enrolled in a science area or those looking for a basic understanding of translational science.
The included reading materials are informative and thought-provoking.
"The paradigm of research activities and milestones shown here is comprehensive and worth emulating (or, at the very least, considered) by research institutions, agencies and funders outside the United States."
"For people who are already enrolled in a science area it will be a very easy-to-catch course, and even if you are not, it is not a difficult subject."
"It is not a difficult subject."
This course is a good introduction to translational science.
"It is a great course for whom seek an introduction to the exciting field of Translational Science."
"It's a very interesting course although it is indeed very introductory."
"This course is a great introduction to the field of translational science."
The course presents diverse perspectives on translational science.
"The material is also rich with engaging examples that highlight the diverse and extensive research prowess and achievements of the institution hosting this course."
"This course really changed my view about how healthcare research is being addressed today."
"I have been communicating about translational and clinical medicine as part of my job but have no formal training in science or medicine, so found it very insightful to have a more in-depth introduction to the topic."
Interviews with researchers in the field provide valuable insights.
"Very informative and comprehensive course included detailed interviews with subject matter experts."
"The course shows the variety of how Translational Science is done."
"Having the interviews with researchers was really helpful to help contextualise the theory."
Activities
Be better prepared
before
your course. Deepen your understanding
during
and
after
it. Supplement your coursework and achieve mastery of the topics covered
in Introduction to Translational Science with these
activities:
Follow online tutorials on translational research software
Show steps
Enhance your proficiency in using software tools essential for translational research data analysis and management.
Browse courses on
Data Analysis
Show steps
-
Identify a reputable online tutorial or course on translational research software
-
Follow the tutorial step-by-step, completing all exercises and assignments
-
Apply the software to a small-scale translational research project to gain practical experience
Solve translational research case studies
Show steps
Engage with real-world examples to reinforce your understanding of translational research principles and methodologies.
Browse courses on
Translational Research
Show steps
-
Identify a translational research case study from a reputable source
-
Read and analyze the study, focusing on the research design, methods, and results
-
Critically evaluate the study's strengths and weaknesses
-
Summarize the key findings and implications for translational research
Develop a translational research research proposal
Show steps
Apply your knowledge of translational research principles to design and write a compelling research proposal that addresses an unmet clinical need.
Browse courses on
Grant Writing
Show steps
-
Identify a research problem and develop a hypothesis
-
Design a research study to test your hypothesis, including methodology, data collection, and analysis plan
-
Draft a research proposal outlining your study design, objectives, and expected outcomes
-
Seek feedback from experts in the field and revise your proposal accordingly
Show all three activities
Follow online tutorials on translational research software
Show steps
Enhance your proficiency in using software tools essential for translational research data analysis and management.
Browse courses on
Data Analysis
Show steps
Show steps
Show steps
- Identify a reputable online tutorial or course on translational research software
- Follow the tutorial step-by-step, completing all exercises and assignments
- Apply the software to a small-scale translational research project to gain practical experience
Solve translational research case studies
Show steps
Engage with real-world examples to reinforce your understanding of translational research principles and methodologies.
Browse courses on
Translational Research
Show steps
Show steps
Show steps
- Identify a translational research case study from a reputable source
- Read and analyze the study, focusing on the research design, methods, and results
- Critically evaluate the study's strengths and weaknesses
- Summarize the key findings and implications for translational research
Develop a translational research research proposal
Show steps
Apply your knowledge of translational research principles to design and write a compelling research proposal that addresses an unmet clinical need.
Browse courses on
Grant Writing
Show steps
Show steps
Show steps
- Identify a research problem and develop a hypothesis
- Design a research study to test your hypothesis, including methodology, data collection, and analysis plan
- Draft a research proposal outlining your study design, objectives, and expected outcomes
- Seek feedback from experts in the field and revise your proposal accordingly
Show all three activities
Career center
Learners who complete Introduction to Translational Science will develop knowledge and skills
that may be useful to these careers:
Clinical Research Associate
Clinical Research Associate
Clinical Research Associates play a crucial role in the clinical research process, ensuring that clinical trials are conducted ethically and safely. This course provides a strong foundation in the principles and practices of translational science, which is essential for understanding the development and implementation of clinical trials. By gaining a comprehensive understanding of translational research, you will be well-equipped to manage clinical trials effectively and contribute to the advancement of medical research.
Medical Science Liaison
Medical Science Liaison
Medical Science Liaisons serve as a bridge between pharmaceutical companies and healthcare providers, providing scientific information and support. This course will provide you with a deep understanding of translational research and its impact on clinical practice, enabling you to effectively communicate complex scientific concepts to healthcare professionals. By gaining knowledge of the different stages of translational research, you will be able to effectively translate research findings into practical applications, ultimately improving patient outcomes.
Regulatory Affairs Specialist
Regulatory Affairs Specialist
Regulatory Affairs Specialists ensure that medical products meet regulatory requirements and are safe for public use. This course provides a comprehensive overview of the regulatory landscape for clinical research and medical devices, helping you to understand the complexities of regulatory processes. By gaining a solid foundation in translational research, you will be well-equipped to navigate the regulatory landscape effectively and ensure the safety and efficacy of medical products.
Research Scientist
Research Scientist
Research Scientists conduct scientific research to advance knowledge and develop new technologies. This course will provide you with a strong foundation in the principles and practices of translational research, enabling you to design and conduct research studies effectively. By gaining a comprehensive understanding of translational research, you will be well-equipped to contribute to the advancement of medical research and improve patient outcomes.
Clinical Trial Manager
Clinical Trial Manager
Clinical Trial Managers oversee the day-to-day operations of clinical trials, ensuring that they are conducted efficiently and in compliance with regulations. This course provides a comprehensive overview of the clinical trial process and the role of translational research in developing new treatments and interventions. By gaining a deep understanding of translational science, you will be well-equipped to manage clinical trials effectively and contribute to the advancement of medical research.
Science Writer
Science Writer
Science Writers communicate complex scientific information to a non-scientific audience. This course provides a strong foundation in the principles and practices of translational research, enabling you to effectively translate scientific findings into clear and concise language. By gaining a comprehensive understanding of translational research, you will be well-equipped to write engaging and informative articles that increase public awareness of medical advancements.
Healthcare Consultant
Healthcare Consultant
Healthcare Consultants provide advice and guidance to healthcare organizations on a variety of topics, including clinical research, regulatory affairs, and patient care. This course will provide you with a comprehensive understanding of the healthcare industry and the role of translational research in improving patient outcomes. By gaining knowledge of the different stages of translational research, you will be able to effectively advise healthcare organizations on how to implement new technologies and treatments.
Biostatistician
Biostatistician
Biostatisticians apply statistical methods to solve problems in healthcare and medical research. This course provides a strong foundation in the principles and practices of translational research, enabling you to effectively analyze and interpret clinical data. By gaining a comprehensive understanding of translational science, you will be well-equipped to contribute to the design and analysis of clinical trials and other research studies.
Clinical Pharmacist
Clinical Pharmacist
Clinical Pharmacists provide medication therapy management and counseling to patients. This course will provide you with a comprehensive overview of the drug development process and the role of translational research in developing new and improved treatments. By gaining a deep understanding of translational science, you will be well-equipped to provide patients with evidence-based medication therapy and counseling.
Epidemiologist
Epidemiologist
Epidemiologists investigate the distribution and determinants of health-related states or events in specified populations. This course provides a comprehensive overview of the principles and practices of translational research, enabling you to effectively design and conduct epidemiological studies. By gaining a deep understanding of translational science, you will be well-equipped to contribute to the prevention and control of diseases.
Patient Advocate
Patient Advocate
Patient Advocates represent the interests of patients and their families, ensuring that they have access to quality healthcare. This course will provide you with a deep understanding of the healthcare system and the role of translational research in improving patient outcomes. By gaining knowledge of the different stages of translational research, you will be able to effectively advocate for patients and ensure that they receive the best possible care.
Nurse Practitioner
Nurse Practitioner
Nurse Practitioners provide healthcare services independently or in collaboration with physicians. This course will provide you with a comprehensive overview of the healthcare system and the role of translational research in improving patient outcomes. By gaining knowledge of the different stages of translational research, you will be able to effectively collaborate with physicians and other healthcare professionals to provide high-quality patient care.
Physician Assistant
Physician Assistant
Physician Assistants provide healthcare services under the supervision of a physician. This course will provide you with a comprehensive overview of the healthcare system and the role of translational research in improving patient outcomes. By gaining knowledge of the different stages of translational research, you will be able to effectively collaborate with physicians and other healthcare professionals to provide high-quality patient care.
Health Economist
Health Economist
Health Economists apply economic principles to analyze healthcare issues and policies. This course provides a comprehensive overview of the healthcare system and the role of translational research in improving patient outcomes. By gaining knowledge of the different stages of translational research, you will be able to effectively analyze the economic impact of new technologies and treatments.
Social Worker
Social Worker
Social Workers provide support and services to individuals and families facing challenges. This course will provide you with a comprehensive understanding of the social determinants of health and the role of translational research in improving health equity. By gaining knowledge of the different stages of translational research, you will be able to effectively advocate for social policies and programs that improve the health and well-being of individuals and communities.
For more career information including salaries, visit:
OpenCourser.com/course/o8hyhr/introduction
Reading list
We've selected six books
that we think will supplement your
learning. Use these to
develop background knowledge, enrich your coursework, and gain a
deeper understanding of the topics covered in
Introduction to Translational Science.
This practical guide provides a step-by-step approach to conducting clinical research, covering topics such as study design, data collection, analysis, and interpretation.
A report from the World Health Organization that discusses the challenges and opportunities in translational research.
Save
This textbook provides a comprehensive overview of biostatistics, covering topics such as descriptive statistics, inferential statistics, and regression analysis.
This textbook provides a comprehensive overview of clinical epidemiology, covering topics such as study design, data collection, analysis, and interpretation.
A comprehensive textbook that covers the fundamentals of translational research.
A report that examines the role of patient-centered outcomes research in accelerating translational research.
For more information about how these books relate to this course, visit:
OpenCourser.com/course/o8hyhr/introduction
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Effort
The six lessons will be covered in three weeks and require approximately 2-3 hours per week.
Level
Introductory
Via
Coursera
Institution
University of Rochester
Instructor
Martin S. Zand, MD, PhD
Language
English
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Good to know
The course focuses on translational science, which is at the forefront of medical research and has the potential to revolutionize patient care
Taught by respected medical professionals with extensive experience in translational research, ensuring learners are exposed to cutting-edge knowledge and insights
Provides a comprehensive overview of translational science, encompassing its principles, methodologies, and impact on healthcare
Suitable for individuals interested in pursuing a career in translational research or seeking a deeper understanding of its role in healthcare innovation
May require a background in biomedical sciences or related fields to fully grasp the concepts presented
Utilizes a multi-modal approach with videos, readings, and interactive materials to enhance learning
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